Clinical Physiology of Circulation

ISSN 1814-6910 (Print)
ISSN 2410-9134 (Online)

 

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Issue's catalogue ➤ КФК. 2020; 17 (4): 241-328 ➤ Оценка упругоэластических свойств брахиоцефальных артерий у здоровых детей различного возраста

Elastic properties evaluation of brachyocephalic arteries at healthy children of different ages

Authors: Abramova M.F., Ivanov S.V., Stepanova I.A., Shurupova N.S.

Company:
5 1 Sukhareva Scientific and Practical Сenter for Mental Health of Children and Adolescents, Moscow, 119334, Russian Federation
2 Pirogov Russian National Research Medical University, Moscow, 117997, Russian Federation
3 Peoples' Friendship University of Russia, Moscow, 117198, Russian Federation
4 Central Clinical Hospital “Russian Railways-Medicine”, Moscow, 129128, Russian Federation
5 Morozov Children's City Clinical Hospital, Moscow, 119049, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-6910-2020-17-4-313-318

UDC: 616.132.5-053.2

Link: Clinical Physiology of Blood Circulaiton. 2020; 4 (17): 313-318

Quote as: Abramova M.F., Ivanov S.V., Stepanova I.A., Shurupova N.S. Elastic properties evaluation of brachyocephalic arteries at healthy children of different ages. Clinical Physiology of Circulation. 2020; 17 (4): 313–8 (in Russ.). DOI: 10.24022/1814-6910-2020-17-4-313-318

Keywords:  cerebrovascular diseases children echo-tracking local stiffness of an arterial wall carotid arteries

Received / Accepted:  18.06.2020 / 29.06.2020

Full text:  

Abstract

Objective. Investigations of elastic properties technology echo-tracking of brachyocephalic arteries at healthy children of different ages were carried out.

Material and methods. 150 healthy children from 5 to 17 years were investigated. 34 healthy persons from 30 to 40 age have been investigated also. Standard B-mode and a technology echo-tracking were used. Elastic properties of brachyocephalic arteries were evaluated by the following parameters: cross-sectional complaince coefficient, index of arterial stiffness (SI), elastic modulus (Peterson) (EM), pulse wave velocity (PWV).

Results. Parameters: SI, EM, PWV increased with age. Intensive increasing of PWV was noticed at 10–12 years (puberty age). Stiffness indexes at adults of 30–40 years old were significantly higher and elasticity was lower in comparison with children (p <0.05).

Conclusions. The results show that echo-tracking is a highly sensitive method in assessment of the elastic properties of the carotid artery, which allows to identify age differences in vessel stiffness (elasticity). Trend to lower of elasticity with age at children and rising of stiffness was observed. These properties may be early detection markers of brain artery pathology.

References

  1. De Veber G. The epidemiology of childhood stroke. In: Ganesan V., Kirkham F. (Eds). Stroke and cerebrovascular disease in childhood. London: Mac Keith Press; 2011: 22–6.
  2. Rivkin M.J., Bernard T.J., Dowling M.M., Amlie-Lefond C. Guidelines for urgent management of stroke in children. Pediatr. Neurol. 2016; 56: 8–17. DOI: 10.1016/ j.pediatrneurol.2016.08.019
  3. Зыков В.П., Комарова И.Б., Дьяконова Е.Н., Гузева В.И., Львова О.А. Инсульты у детей. В кн.: Гузева В.И. (ред.) Федеральное руководство по детской неврологии. М.: Специальное издательство медицинских книг; 2016. [Zykov V.P., Komarova I.B., D'yakonova E.N., Guzeva V.I., L'vova O.A. Strokes in children. In: Guzeva V.I. (Ed). Federal guidance on pediatric neurology. Moscow; 2016 (in Russ.).]
  4. Колтунов И.Е., Щедеркина И.О. Проблема инсульта у детей: актуальность и перспективы. Детский доктор. 2016; 3 (3): 10–1. [Koltunov I.E., Shchederkina I.O. The problem of stroke in children: relevance and prospects. Children's Doctor. 2016; 3 (3): 10–1 (in Russ.).]
  5. Абрамова М.Ф., Шурупова Н.С. Ультразвуковое дуплексное сканирование и клинические особенности экстракраниальных аномалий внутренних сонных артерий у детей. Педиатрическая фармакология. 2009; 6 (3): 80–4. [Abramova M.F., Shurupova N.S. Ultrasound duplex scanning and clinical features of extracranial abnormalities of the internal carotid arteries in children. Pediatric Pharmacology. 2009; 6 (3): 80–4 (in Russ.).]
  6. Абрамова М.Ф. Клинико-диагностические особенности брахиоцефальной патологии у детей. Клиническая физиология кровообращения. 2012; 4: 55–8. [Abramova M.F. Clinical and diagnostic features of brachiocephalic pathology in children. Clinical Physiology of Circulation. 2012; 4: 55–8 (in Russ.).]
  7. Celermajer D.S., Sorensen K.E., Gooch V.M., Spiegelhalter D.J., Miller O.I., Sullivan I.D. et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet. 1992; 340 (8828): 1111–5. DOI: 10.1016/0140-6736(92)93147-f
  8. Филиппов Г.П., Бороненко К.В., Плотникова И.В., Мордовин В.Ф., Ситкова Е.С., Сафронов А.Д. Неинвазивная оценка ригидности артерий у детей и подростков в семьях с отягощенной наследственностью по артериальной гипертензии. Сибирский медицинский журнал. 2014; 29 (3): 68–72. [Filippov G.P., Boronenko K.V., Plotnikova I.V., Mordovin V.F., Sitkova E.S., Safronov A.D. Non-invasive assessment of arterial stiffness in children and adolescents in families with burdened heredity for arterial hypertension. Siberian Medical Journal. 2014; 29 (3): 68–72 (in Russ.).]
  9. Данилюк Л.В., Погодина А.В., Рычкова Л.В. Жесткость артериальных сосудов: основные детерминанты, методы оценки и связь с ожирением у детей (обзор литературы). Acta Biomedica Scietifica. 2017; 2 (5, Часть 1): 106–10. DOI: 10.12737/article_59e85cdc033e93.89915718 [Danilyuk L.V., Pogodina A.V., Rychkova L.V. Arterial stiffness: key determinants, assessment methods, and association with childhood obesity (literature review). Acta Biomedica Scietifica. 2017; 2 (5, Part 1): 106–10 (in Russ.). DOI: 10.12737/article_59e85cdc033e93. 89915718]
  10. Болотова Н.В., Посохова Н.В., Новикова Е.П., Дронова Е.Г., Евсеева Е.А. Состояние сосудистой стенки у детей и подростков с метаболическим синдромом. Проблемы эндокринологии. 2014; 2: 8–12. [Bolotova N.V., Posokhova N.V., Novikova E.P., Dronova E.G., Evseeva E.A. The state of the vascular wall in children and adolescents with metabolic syndrome. Problems of Endocrinology. 2014; 2: 8–12 (in Russ.).]
  11. Feber J., Ahmed M. Hypertension in children: new trends and challenges. Clin. Sci. (Lond). 2010; 119: 151–61. DOI: 10.1042/CS20090544
  12. Wadwa R.P., Urbina E.M., Anderson A.M., Hamman R.F., Dolan L.M., Rodriguez B.L. et al. Measures of arterial stiffness in youth with type 1 and type 2 diabetes: the SEARCH for diabetes in youth study. Diabetes Care. 2010; 33: 881–6. DOI: 10.2337/dc09-0747
  13. Borlotti A., Khir A.W., Rietzschel E.R., De Buyzere M.L., Vermeersch S., Segers P. Noninvasive determination of local pulse wave velocity and wave intensity: changes with age and gender in the carotid and femoral arteries of healthy human. J. Appl. Physiol. 2012; 113 (5): 727–35. DOI: 10.1152/japplphysiol. 00164.2012
  14. Laurent S., Boutouyrie P., Lacolley P. Structural and genetic bases of arterial stiffness. Hypertension. 2005; 45 (6): 1050–5. DOI: 10.1161/01.HYP.0000164580.39991.3d
  15. Hidvégi E.V., Illyés M., Benczúr B., Böcskei R.M., Rátgéber L., Lenkey Z. et al. Reference values of aortic pulse wave velocity in a large healthy population aged between 3 and 18 years. J. Hypertens. 2012; 30 (12): 2314–21. DOI: 10.1097/HJH.0b013e328359562c
  16. Cheung Y.F., Wong S.J., Ho M.H. Relationship between carotid intima-media thickness and arterial stiffness in children after Kawasaki disease. Arch. Dis. Child. 2007; 92 (1): 43–7. DOI: 10.1136/adc.2006.096628
  17. Riggio S., Mandraffino G., Sardo M.A., Ludicello R., Camarda N., Imbalzano E. et al. Pulse wave velocity and augmentation index, but not intima media thickness, are early indicators of vascular damage in hypercholesterolemic children. Eur. J. Clin. Invest. 2010; 40 (3): 250–7. DOI: 10.1111/j.1365-2362.2010. 02260.x
  18. Cheung Y.F. Arterial stiffness in the young: assessment, determinants, and implications. Korean Circ. J. 2010; 40 (4): 153–62. DOI: 10.4070/kcj.2010.40.4.153
  19. Pandit D., Kinare A., Chiplonkan S., Khadilkar A., Khadilkar V. Carotid arterial stiffness in overweight and obese Indian children. J. Pediatr. Endocrinol. Metab. 2011; 24: 97–102. DOI: 10.1515/jpem.2011.086
  20. Núñez F, Martínez-Costa C., Sánchez-Zahonero J., Morata J., Chorro F.J., Brines J. Carotid artery stiffness as an early marker of vascular lesions in children and adolescents with cardiovascular risk factors. Rev. Esp. Cardiol. 2010; 63 (11): 1253–60. DOI: 10.1016/s1885- 5857(10)70250-4
  21. Ozcetin M., Celikyay Z.R., Celik A., Yilmaz R., Yerli Y., Erkorkmaz U. The importance of carotid artery stiffness and increased intima-media thickness in obese children. S. Afr. Med. J. 2012; 102 (5): 295–9. DOI: 10.7196/samj.5351
  22. Платонов А.Е. Статистический анализ в медицине и биологии: задачи, терминология, логика, компьютерные методы. М.: Издательство РАМН; 2000: 52. [Platonov A.E. Statistical analysis in medicine and biology: tasks, terminology, logic, computer methods. Moscow; 2000: 52 (in Russ.).
  23. O'Rourke M.F., Hashimoto J. Mechanical factors in arterial aging. A clinical perspective. JACC. 2007; 50: 1–13. DOI: 10.1016/j.jacc.2006.12.050
  24. Leloup A.J., Van Hove C.E., Heykers A., Schrijvers D.M., De Meyer G.R., Fransen P. Elastic and muscular arteries differ in structure, basal NO production and voltage-gated Ca(2+)-channels. Front. Physiol. 2015; 6: 375. DOI: 10.3389/fphys.2015.00375
  25. Yang S., Wang D., Zhang H., He W., Chen B. Echotracking technology assessment of carotid artery stiffness in patients with coronary slow flow. Ultrasound Med. Biol. 2015; 41 (1): 72–6. DOI: 10.1016/j.ultrasmedbio.2014.08.015
  26. A multi-center collaborative project for the establishment of normal reference values of arterial elasticity in healthy Chinese. Measurement of the common carotid artery elasticity in healthy Chinese using the e-traking technology. Chin. J. Ultrason. 2008; 17 (7): 571–5.

About Authors

  • Marina F. Abramova, Cand. Med. Sc., Senior Researcher, Associate Professor of Chair of Ultrasound Diagnostics; ORCID
  • Sergey V. Ivanov, Dr. Med. Sc., Professor of Chair of Functional and Radiation Diagnostics, Head of Department of Functional Diagnostics
  • Irina A. Stepanova, Ultrasonic Diagnostician; ORCID
  • Nataliya S. Shurupova, Ultrasonic Diagnostician; ORCID

 If you found mistakes, select text and press Alt+A