Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Perioperative genomics: methodological approaches, genetic variability and response to surgical injury. Part 1

Authors: Koksheneva I.V., Zakaraya I.T.

Company:
Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, 121552, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-6910-2021-18-1-5-15

UDC: 576.315.42-089

Link: Clinical Physiology of Blood Circulaiton. 2021; 1 (18): 5-15

Quote as: Koksheneva I.V., Zakaraya I.T. Perioperative genomics: methodological approaches, genetic variability and response to surgical injury. Part 1. Clinical Physiology of Circulation. 2021; 18 (1): 5–15 (in Russ.). DOI: 10.24022/1814-6910-2021-18-1-5-15

Received / Accepted:  22.10.2020 / 03.11.2020

Full text:  

Abstract

Currently, there is an ever wider translation of genomic technologies into the fields of medicine related to the perioperative management of patients, a new discipline is being formed – perioperative genomics. The introduction of genomic data into clinical practice will make it possible in the long term to identify patients with "vulnerable points", which can become an important aspect of perioperative management (preoperative preparation of organs and systems for the forthcoming operation, postoperative monitoring). And also provide additional information for choosing a treatment method (endovascular intervention, surgery on a beating heart or using extracorporeal circulation), choosing the type of coronary conduit, choosing the optimal drug therapy regimen in the postoperative period. To integrate the results of genetic studies into clinical practice, clinicians must understand the patterns of changes in the human genome, the principles of analysis of gene expression. The article discusses general genetic/genomic concepts, highlights the current and future possibilities of using genomic technologies to stratify perioperative risk, predict the results of surgical treatment, and identify new directions for perioperative organ protection.

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****
  1. Podgoreanu M.V., Schwinn D.A. New paradigms in cardiovascular medicine: emerging technologies and practices: perioperative genomics. J. Am. Coll. Cardiol. 2005; 46 (11): 1965–77. DOI: 10.1016/j.jacc.2005. 08.040
  2. Nagele P. Perioperative genomics. Best. Pract. Res. Clin. Anaesthesiol. 2011; 25 (4): 549–55. DOI: 10.1016/j.bpa.2011.09.001
  3. Buziashvili Yu.I., Koksheneva I.V., Abukov S.T., Sandukhadze B.R. The value of genetic polymorphism of inflammatory response mediators in the development of complications after cardiac surgery (literature review). Cardiology and Cardiovascular Surgery. 2016; 9 (1): 13—9 (in Russ.).
  4. Sigurdsson M.I., Muehlschlegel J.D. Perioperative genomics: coming soon to (operating) theatres near you. Can. J. Anaesth. 2016; 63 (4): 382–5. DOI: 10.1007/s12630-015-0577-7
  5. Gabriel R.A., Burton B.N., Urman R.D., Waterman R.S. Genomics testing and personalized medicine in the preoperative setting. Surg. Oncol. Clin. N. Am. 2020; 29 (1): 73–86. DOI: 10.1016/j.soc.2019.08.006
  6. Bain C.R., Shaw A.D. Genetics and epigenetics in perioperative medicine. Curr. Opin. Crit. Care. 2012; 18 (5): 548–54. DOI: 10.1097/MCC.0b013e328357af6d
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  28. Koksheneva I.V. Systemic and genetic approaches in cardiovascular medicine: opportunities and perspectives. Bulletin of Bakoulev Center. Cardiovascular Deseases. 2018; 19 (4): 439–46 (in Russ.). DOI: 10.24022/1810-0694-2018-19-4-439-446

About Authors

  • Inna V. Koksheneva, Dr. Med. Sc., Senior Researcher; ORCID
  • Irakliy T. Zakaraya, Junior Researcher

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