Clinical Physiology of Circulation

ISSN 1814-6910 (Print)
ISSN 2410-9134 (Online)

 

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Issue's catalogue ➤ КФК. 2022; 19 (1): 1-96 ➤ Гипоксия и дефицит железа: синергичные эффекты на организм

Hypoxia and iron deficiency: synergistic effects on the body

Authors: Kupryashov A.A., Rivnyak M.I.

Company:
Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-6910-2022-19-1-57-69

UDC: 616.155.194.8

Link: Clinical Physiology of Blood Circulaiton. 2022; 1 (19): 57-69

Quote as: Kupryashov A.A., Rivnyak M.I. Hypoxia and iron deficiency: synergistic effects on the body. Clinical Physiology of Circulation. 2022; 19 (1): 57–69 (in Russ.). DOI: 10.24022/1814-6910-2022-19-1-57-69

Keywords:  heart failure iron deficiency proteins containing iron

Received / Accepted:  24.11.2021 / 17.01.2022

Full text:  

Abstract

To date, there is an accumulation of data on the role of iron metabolism in hypoxia. The most important role of iron is determined by the functions of proteins that contain this metal in their structure. In recent years, significant progress has been made in understanding the main links in the regulation of iron metabolism, in the function of proteins such as ferroportin, a divalent metal transporter 1, cytochrome b, iron regulatory proteins, ironsensitive elements, hepcidin. Particular attention is paid to hepcidin, which is recognized as a key iron-regulatory protein that affects both the absorption of dietary iron and the release of iron from macrophages during its recirculation from senescent erythrocytes. Data on the relationship of hepcidin with other iron-regulatory proteins and the effect of hypoxia-inducible factor on iron metabolism are presented. In this review, a systematization and analysis of literature data have been carried out to deter mine the main directions of further research and a targeted search for ways to improve the quality of treatment of patients with chronic heart failure associated with iron deficiency.

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About Authors

  • Aleksey A. Kupryashov, Dr. Med. Sci., Head of Department of Clinical and Industrial Transfusiology with the Diagnostic Laboratory; ORCID
  • Marina I. Rivnyak, Doctor-Researcher; ORCID

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