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«Клиническая физиология кровообращения»

ISSN 1814-6910 (Print)
ISSN 2410-9134 (Online)

 

Главный редактор

Лео Антонович Бокерия, доктор медицинских наук, профессор, академик РАН и РАМН, президент ФГБУ «НМИЦ ССХ им. А.Н. Бакулева» МЗ РФ


Каталог статей ➤ КФК. 2023; 20 (1): 1-88 ➤ Чрескожная стимуляция аурикулярной ветви блуждающего нерва: потенциал метода лечения различных сердечно-сосудистых заболеваний

Чрескожная стимуляция аурикулярной ветви блуждающего нерва: потенциал метода лечения различных сердечно-сосудистых заболеваний

Авторы: Шварц В.А., Сижажев Э.М.

Организация:
ФГБУ «Национальный медицинский исследовательский центр сердечно-сосудистой хирургии им. А.Н. Бакулева» Минздрава России, Москва, Российская Федерация

Для корреспонденции: Сведения доступны для зарегистрированных пользователей.

Раздел: Обзоры

DOI: https://doi.org/10.24022/1814-6910-2023-20-1-5-15

УДК: 616.12-089.819.5

Библиографическая ссылка: Клиническая физиология кровообращения. 2023; 1 (20): 5-15

Цитировать как: Шварц В.А., Сижажев Э.М. . Чрескожная стимуляция аурикулярной ветви блуждающего нерва: потенциал метода лечения различных сердечно-сосудистых заболеваний. Клиническая физиология кровообращения. 2023; 1 (20): 5-15. DOI: 10.24022/1814-6910-2023-20-1-5-15

Ключевые слова: анатомия вагуса, физиология вагуса, чрескожная неинвазивная стимуляция вагуса, аурикулярная ветвь блуждающего нерва, ишемическая болезнь сердца, фибрилляция предсердий

Поступила / Принята к печати:  19.01.2023 / 15.03.2023

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Аннотация

Представлен обзор современных исследований по изучению электрической стимуляции аурикулярной ветви блуждающего нерва. Описаны клинические предпосылки появления метода, анатомическое обоснование выбора данной зоны стимуляции, а также возможные физиологические механизмы, происходящие при стимуляции. Кроме того, приводятся некоторые современные экспериментальные исследования по применению чрескожной стимуляции вагуса при различных патологиях, в том числе при сердечно-сосудистых заболеваниях. Авторами также описаны наиболее часто встречающиеся в литературных источниках устройства для неинвазивной стимуляции вагуса (GammaCore®, Parasym™, Cerbomed NEMOS®, taVNS Stimulator by Soterix Medical) и приведены особенности их применения.
В настоящее время чрескожная стимуляция блуждающего нерва является перспективной, но малоизученной методикой, которая потенциально может быть альтернативным и безопасным вмешательством при широком спектре сердечно-сосудистых заболеваний. Поскольку проведенные на сегодняшний день исследования включают малое число участников, это затрудняет оценку клинической значимости метода. Для получения валидной научно-доказательной базы знаний о терапевтических эффектах стимуляции аурикулярной ветви блуждающего нерва на сердечно-сосудистую систему необходимы дальнейшие исследования с большой выборкой участников и последующим обобщением полученных данных в виде метаанализов.

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  1. Prescott S.L., Liberles S.D. Internal senses of the vagus nerve. Neuron. 2022; 110 (4): 579–99. DOI: 10.1016/j.neuron.2021.12.020
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  3. Kharbanda R.K., van der Does W.F.B., van Staveren L.N., Taverne Y.J.H.J., Bogers A.J.J.C., de Groot N.M.S. Vagus nerve stimulation and atrial fibrillation: revealing the paradox. Neuromodulation. 2022; 25 (3): 356–65. DOI: 10.1016/j.neurom.2022.01.008
  4. Asconapé J.J., Moore D.D., Zipes D.P., Hartman L.M., Duffell W.H.Jr. Bradycardia and asystole with the use of vagus nerve stimulation for the treatment of epilepsy: a rare complication of intraoperative device testing. Epilepsia. 1999; 40 (10): 1452–4. DOI: 10.1111/j.1528- 1157.1999.tb02019.x
  5. Liu A., Rong P., Gong L., Song L., Wang X., Li L. et al. Efficacy and safety of treatment with transcutaneous vagus nerve stimulation in 17 patients with refractory epilepsy evaluated by electroencephalogram, seizure frequency, and quality of life. Med. Sci. Monit. 2018; 24: 8439–48. DOI: 10.12659/MSM.910689
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Об авторах

  • Шварц Владимир Александрович, д-р мед. наук, вед. науч. сотр., профессор кафедры сердечно-сосудистой хирургии с курсом аритмологии и клинической электрофизиологии; ORCID
  • Сижажев Эльдар Муратович, ординатор; ORCID

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