Научно-практический журнал
«Клиническая физиология кровообращения»

Главный редактор

Лео Антонович Бокерия, доктор медицинских наук, профессор, академик РАН и РАМН, директор ФГБУ «НМИЦССХ им. А.Н. Бакулева» МЗ РФ

Сепсис и септический шок в сердечно-сосудистой хирургии: современные методы диагностики и лечения

Авторы: Бокерия Л.А., Гасымов Э.Г., Абдулгасанов Р.А., Абдулгасанова М.Р.

Организация:
ФГБУ «Национальный медицинский исследовательский центр сердечно-сосудистой хирургии им. А.Н. Бакулева» (президент – академик РАН и РАМН Л.А. Бокерия) Минздрава России, Рублевское ш., 135, Москва, 121552, Российская Федерация

Для корреспонденции: Сведения доступны для зарегистрированных пользователей.

Раздел: Обзоры

DOI: https://doi.org/10.24022/1814-6910-2021-18-2-97-108

УДК: 616.12-089: 616.94

Библиографическая ссылка: Клиническая физиология кровообращения. 2021; 2 (18): 97-108

Цитировать как: Бокерия Л.А., Гасымов Э.Г., Абдулгасанов Р.А., Абдулгасанова М.Р. . Сепсис и септический шок в сердечно-сосудистой хирургии: современные методы диагностики и лечения. Клиническая физиология кровообращения. 2021; 2 (18): 97-108. DOI: 10.24022/1814-6910-2021-18-2-97-108

Ключевые слова: сепсис, септический шок, инфузионная терапия, антибиотикотерапия, хирургическое лечение

Поступила / Принята к печати:  18.01.2021 / 02.02.2021

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Аннотация

Несмотря на совершенствование хирургических методов и защиты миокарда, анестезиологического пособия, развитие периоперационного инфаркта миокарда при кардиохирургических операциях остается нередким явлением и сочетается со снижением ближайшей и отдаленной выживаемости. В основе патофизиологии интраоперационного инфаркта миокарда при кардиохирургических операциях лежат три ведущих механизма: 1) системное и локальное воспаление; 2) нарушения в свертывающей системе крови; 3) нейроэндокринный стресс. Генетическая вариабельность присутствует в каждом из упомянутых регуляторных путей. Генетические варианты различных путей могут присутствовать у одного пациента, модулируя величину повреждения миокарда. В данном обзоре представлены опубликованные данные о выявленных генетических вариантах, связанных с периоперационным инфарктом миокарда у пациентов, перенесших кардиохирургические операции. В перспективе генетические исследования смогут помочь в предоперационной прогностической оценке риска развития инфаркта миокарда.

Литература

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Об авторах

  • Кокшенёва Инна Валериевна, доктор мед. наук, ст. науч. сотр.; ORCID
  • Закарая Ираклий Темурович, мл. науч. сотр.
  • Малороева Амина Исаевна, аспирант

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