Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Pathogenetic aspects of chronic venous insufficiency, trophic disorders and venous ulcers

Authors: Malinin A.A.1, Chomaeva A.A.2, Argunova S.Sh.3, Dzucev V.R.4

Company:
1 Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russian Federation
2 Treatment and Rehabilitation Center, Cherkessk, Russian Federation
3 Karachay-Cherkess Republican Clinical Hospital, Cherkessk, Russian Federation
4 Republican Clinical Hospital, Vladikavkaz, Russian Federation

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DOI: https://doi.org/10.24022/1814-6910-2025-22-2-150-161

UDC: 616-009.85:616.14-007.64

Link: Clinical Physiology of Blood Circulaiton. 2025; 22 (2): 150-161

Quote as: Malinin A.A., Chomaeva A.A., Argunova S.Sh., Dzucev V.R. Pathogenetic aspects of chronic venous insufficiency, trophic disorders and venous ulcers. Clinical Physiology of Сirculation. 2025; 22 (2): 150–161 (in Russ.). DOI: 10.24022/1814-6910-2025-22-2-150-161

Received / Accepted:  16.05.2025 / 30.05.2025

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Abstract

The review analyzes works devoted to the pathogenesis of CVI in the stage of trophic disorders, as well as trophic venous ulcers in patients with various etiologies of the disease.

The review is devoted to identifying various pathogenetic mechanisms for the development of severe CVI to improve the knowledge of outpatient and inpatient physicians to understand the challenges of treating this complex category of patients.

CVI in the stage of trophic disorders is a socio-economic problem that affects various aspects of life and quality of life, as well as the risk of disability. The presence of a trophic venous ulcer is associated with the need for ongoing treatment and dressings and the appointment of drug therapy. Risk factors for the development of trophic venous ulcers are of great importance for preventing their occurrence and initiating timely and sufficiently long-term treatment.

Knowledge of the pathophysiological processes of trophic venous ulcer development in various etiologies of CVI determines a treatment strategy that can improve its effectiveness. Understanding the various aspects of the pathogenesis of CVI will allow choosing the correct treatment tactics and reducing the number of relapses of trophic venous ulcers.

About Authors

  • Alexander A. Malinin, Dr. Med. Sci., Chief Researcher; ORCID
  • Aida A. Chomaeva, Cardiovascular Surgeon; ORCID
  • Svetlana Sh. Argunova, Cardiovascular Surgeon; ORCID
  • Vitalij R. Dzucev, Cardiovascular Surgeon; ORCID

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