Clinical Physiology of Circulation

ISSN 1814-6910 (Print)
ISSN 2410-9134 (Online)

 

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Issue's catalogue ➤ КФК. 2025; 22 (2): 115-198 ➤ Исходы реваскуляризации миокарда у пациентов с сочетанием ишемической болезни сердца и злокачественных новообразований: предикторы отдаленной летальности

Outco-mes of myocardial revascularization in patients with combination of ischemic heart disease and malignant neoplasms: predictors of long-term mortality

Authors: Rakhmanzhanov A.A., Asymbekova E.U., Khadisov M.B., Borbodoeva B.M., Akhmedov D.R., Sherstyannikova O.M., Buziashvili Yu.I.

Company:
Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-6910-2025-22-2-162-170

UDC: 616.12-008.46-006

Link: Clinical Physiology of Blood Circulaiton. 2025; 22 (2): 162-170

Quote as: Rakhmanzhanov A.A., Asymbekova E.U., Khadisov M.B., Borbodoeva B.M., Akhmedov D.R., Sherstyannikova O.M., Buziashvili Yu.I. Outcomes of myocardial revascularization in patients with combination of ischemic heart disease and malignant neoplasms: predictors of long-term mortality. Clinical Physiology of Сirculation. 2025; 22 (2): 162–170 (in Russ.). DOI: 10.24022/1814-6910-2025-22-2-162-170

Keywords:  coronary artery disease malignant neoplasms coronary artery bypass grafting percutaneous coronary intervention comorbidity mortality predictors cardio-oncology

Received / Accepted:  20.05.2025 / 30.05.2025

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Abstract

Objective – to evaluate the long-term outcomes of surgical and percutaneous myocardial revascularization in patients with a combination of coronary artery disease (CAD) and malignant neoplasms (MN) and to determine independent predictors of long-term mortality.

Material and methods. The retrospective cohort study included 202 patients (mean age 68.2 ± 7.8 years) with verified CAD and concomitant oncopathology, who received treatment in the period 2010–2020. Long-term follow-up data (median 3.4 years, range 0.5–8.0 years) were available for 69 patients. Of these, 18 patients (26%) died in the long-term period. A comparative analysis of clinical and demographic parameters, the results of cardiac surgery and oncological treatment was performed in the groups of survivors (n = 51) and deceased (n = 18). Statistical analysis was performed using the χ2 criterion, Fisher›s exact test, odds ratio (OR) calculation, and multivariate logistic regression.

Results. Independent predictors of long-term mortality were: the presence of chronic heart failure ≥II FC (OR = 6.5; 95% CI 2.0–21.0; p < 0.001), the absence of radical surgical treatment of malignant neoplasms (OR = 24.9; 95% CI 3.5–176.5; p < 0.001), percutaneous coronary intervention (PCI) as the only method of revascularization (OR = 6.5; 95% CI 2.0–21.0; p = 0.048), male gender (OR = 3.5; 95% CI 1.1–10.9; p = 0.049). Multiple coronary artery occlusions (1.3 ± 0.7 vs 1.0 ± 0.2; p = 0.006) and circumflex lesion (88% vs 60%; p = 0.02) were associated with increased mortality. Coronary artery bypass grafting did not increase the risk of death and allowed 80% of patients to receive planned oncological treatment.

Conclusion. In patients with coronary artery disease and active oncopathology, timely surgical myocardial revascularization and radical oncological treatment significantly improves the long-term prognosis. The presence of chronic heart failure and the impossibility of radical treatment of malignant neoplasm are the most significant predictors of unfavorable outcome.

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About Authors

  • Aliyer A. Rakhmanzhanov, Junior Researcher; ORCID
  • Elmira U. Asymbekova, Dr. Med. Sci., Leading Researcher, Cardiologist; ORCID
  • Magomed B. Khadisov, Junior Researcher, Cardiologist; ORCID
  • Baktygul M. Borbodoeva, Cand. Med. Sci., Researcher, Cardiologist; ORCID
  • Daniyal R. Akhmedov, Junior Researcher; ORCID
  • Olga M. Sherstyannikova, Cand. Med. Sci., Research, Cardiologist; ORCID
  • Yuri I. Buziashvili, Dr. Med. Sci., Professor, Academician of the Russian Academy of Sciences, Head of the clinical and diagnostic department; ORCID

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