Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Интраоперационный тромбоцитаферез при кардиохирургических операциях с искусственным кровообращением

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Link: Clinical Physiology of Blood Circulaiton. 2012; (): -

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Abstract

We suggested that refusion of autoplasma, enriched in platelets, which are sequestered by the method of intraoperative thrombocytapheresis (IOTC) can compensate disorders in blood coagulation system. Material and methods. 40 patients, who were referred to the operation on cardiac valvular apparatus and ascending aorta, were divided into IOTC group and the control group. They were matched according to the severity of initial pathology, antropometric, hematologic and hemacoagulation values to the length of cardiopulmonary bypass. Autoplasma with platelets was preserved with hemo separator (Cell- Saver Electa) in IOTC group during preprefusion period. At the average, 632±93.58 ml of plasma were sequestered, platelet content was (198.35±47.56)) ×10^9/L. Hemo separator was used in the ordinary course for refusion of red blood cells in the second group. The level and dynamics of values of clinical blood analysis, coagulogram, thromboelastogram, volumes of perioperative blood loss and blood transfusion were studied. Results. We detected the decrease of perioperative blood loss (p<0.001) and allogenic blood transfusion (p<0.001), more high index of oxygenation (p=0.01), levels of hemoglobin (p=0.003) and platelets (p<0.001) by the end of the operation in IOTC group. Conclusion. Intraoperative thrombocytapheresis is an effective method of blood preservation that can be recommended for reconstructive operations on cardiac valvular apparatus and ascending aorta.

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