Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Current state of antioxidants the use in cardiac surgery

Authors: Brichkin Yu.D., Taranov E.V., Fedorov S.A., Medvedev A.P

Company:
1 Specialized Cardiosurgical Clinical Hospital named after academician B.A. Korolev, Nizhny Novgorod, 603950, Russian Federation
2 Privolzhsky Research Medical University, Nizhny Novgorod, 603005, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-6910-2020-17-4-284-293

UDC: 615.2:616.12-089

Link: Clinical Physiology of Blood Circulaiton. 2020; 4 (17): 284-293

Quote as: Brichkin Yu.D., Taranov E.V., Fedorov S.A., Medvedev A.P. Current state of antioxidants the use in cardiac surgery. Clinical Physiology of Circulation. 2020; 17 (4): 284–93 (in Russ.). DOI: 10.24022/1814-6910-2020-17-4-284-293

Received / Accepted:  07.08.2020 / 18.08.2020

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Abstract

In recent decades, cardiac surgery has significantly improved clinical results. In many respects, this was achieved thanks to the improvement of anesthesiological and perfusion support. However, the mortality rates and the number of postope-rative complications still remain high, which dictates the obvious need to search for and level the triggers that trigger a cascade of pathological reactions that lead to complications. Many authors agree that one of the most significant syndromes is a systemic inflammatory response, which, in turn, is largely due to the production of reactive oxygen species in tissues, the appearance of an excess of cytotoxic oxygen radicals, and the development of oxidative stress (OS). Therefore, the study of the role of OS in the pathogenesis of ischemic and reperfusion injuries in cardiac surgery and the search for methods to combat these processes are extremely relevant. There are many compounds that have varying degrees of antioxidant activity. However, the theoretical base created in recent years, the accumulated experimental and clinical data testifying to the pronounced antioxidant effect of molecular hydrogen, makes the study of the properties and application of this unique antioxidant in cardiac surgery very interesting and promising.

About Authors

  • Yuriy D. Brichkin, Dr. Med. Sc., Anesthesiologist; ORCID
  • Evgeniy V. Taranov, Anesthesiologist; ORCID
  • Sergey A. Fedorov, Cand. Med. Sc., Cardiovascular Surgeon; ORCID
  • Aleksandr P. Medvedev, Dr. Med. Sc., Professor of Chair of Hospital Surgery named after B.A. Korolev, Cardiovascular Surgeon; ORCID

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