Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Cardiac arrhythmias as risk factors of in-stent restenosis

Authors: Vachev A.N., Germanov V.A.

Company:
Samara State Medical University, Samara, 443099, Russian Federation

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DOI: https://doi.org/10.24022/1814-6910-2020-17-4-308-312

UDC: 616.12-008.318

Link: Clinical Physiology of Blood Circulaiton. 2020; 4 (17): 308-312

Quote as: Vachev A.N., Germanov V.A. Cardiac arrhythmias as risk factors of in-stent restenosis. Clinical Physiology of Circulation. 2020; 17 (4): 308–12 (in Russ.). DOI: 10.24022/1814-6910-2020-17-4-308-312

Received / Accepted:  10.09.2020 / 17.09.2020

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Abstract

Objective. To study the influence of cardiac arrhythmias on in-stent restenosis development after urgent percutaneous coronary intervention at patients with acute coronary syndrome (ACS).

Material and methods. The study included 223 patients who had undergone coronary stenting with bare metal stents for ACS and who required subsequent coronary angiography during follow-up period. All the patients were divided into two groups: with in-stent restenosis over 50% and with in-stent restenosis less than 50% or without restenosis. Patients inclurestenosis as well as cardiac arrhythmias.

Results. Haemodynamically significant restenosis over 50% occurred much more frequently at patients with early ventricular extrasystoles over 3000 per day (RR 5.396, p < 0.001) and atrial fibrillation with long pauses over 2 seconds between ventricular contractions (RR 2.984, p < 0.001), considering that other common risk factors of restenosis didn't differ significantly between 2 groups.

Conclusion. Higher risk of in-stent restenosis development at patients with early ventricular extrasystoles over 3000 per day and atrial fibrillation with long pauses between ventricular contractions can be coupled with additional trauma of arterial wall enhancing negative influence of local risk factors. That is why we consider it reasonable to purposefully reveal the above mentioned arrhythmias at patients after urgent coronary stenting with subsequent antiarrhythmic therapy and coronary angiography between 6–12 months after intervention for early restenosis recognition.

About Authors

  • Aleksey N. Vachev, Dr. Med. Sc., Professor, Chief of Faculty Surgery Chair; ORCID
  • Vladimir A. Germanov, Postgraduate; ORCID

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