Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Effects of levosimendan on renal function in patients with acute heart failure

Authors: Rakhimov A.Z., Rustamov B.E., Pirtskhalava S.D., Asymbekova E.U.

Company:
Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, 121552, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-6910-2021-18-1-37-45

UDC: 616.61-008.64:616.12-008.46]:615.2

Link: Clinical Physiology of Blood Circulaiton. 2021; 1 (18): 37-45

Quote as: Rakhimov A.Z., Rustamov B.E., Pirtskhalava S.D., Asymbekova E.U. Effects of levosimendan on renal function in patients with acute heart failure. Clinical Physiology of Circulation. 2021; 18 (1): 37–45 (in Russ.). DOI: 10.24022/1814-6910-2021-18-1-37-45

Received / Accepted:  18.06.2020 / 27.07.2020

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Abstract

Non-glycoside inotropic drugs can be used for short-term treatment of acute heart failure with renal dysfunction (cardiorenal syndrome), especially in conditions with low cardiac output, in order to avoid renal hypoperfusion. Levosimendan appears to be a promising option for improving renal perfusion and improving renal dysfunction in patients with acute heart failure. Despite the neutral results of recent randomized trials, at the current stage it seems obvious that levosimendan is appropriate for use in cardiology and cardiac surgery in patients with acute heart failure with low cardiac output and refractory to diuretics, especially in the presence of renal dysfunction. Its use can help overcome the most difficult and dangerous period during this disease

About Authors

  • Akmal Z. Rakhimov, Cand. Med. Sc., Researcher; ORCID
  • Bakht E. Rustamov, Cand. Med. Sc., Researcher; ORCID
  • Sofia D. Pirtskhalava, Cand. Med. Sc., Cardiologist; ORCID
  • El’mira U. Asymbekova, Dr. Med. Sc., Leading Researcher; ORCID

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