Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Influence of the method of gaseous nitric oxide administration on the effectiveness of myocardial protection during operations with cardiopulmonary bypass

Authors: Pichugin V.V., Domnin S.E., Sandalkin E.V., Ryazanov M.V., Bober V.V.

Company:
1 Privolzhsky Research Medical University, Nizhny Novgorod, Russian Federation
2 Specialized Cardiac Surgical Clinical Hospital named after Academician B.A. Korolev, Nizhny Novgorod, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-6910-2022-19-2-137-146

UDC: 616.12-089.166:616.1-78]-06:616.127-084

Link: Clinical Physiology of Blood Circulaiton. 2022; 2 (19): 137-146

Quote as: Pichugin V.V., Domnin S.E., Sandalkin E.V., Ryazanov M.V., Bober V.V. Influence of the method of gaseous nitric oxide administration on the effectiveness of myocardial protection during operations with cardiopulmonary bypass. Clinical Physiology of Circulation. 2022; 19 (2): 137–46 (in Russ.). DOI: 10.24022/1814-6910-2022-19-2-137-146

Received / Accepted:  07.02.2022 / 09.03.2022

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Abstract

Objective. The aim of the study was a comparative assessment of the inhalation and extracorporeal methods of administering gaseous nitric oxide on the effectiveness of myocardial protection during heart valves surgery with cardiopulmonary bypass (CPB).

Material and methods. The study included 93 patients who underwent heart surgery with CPB. Three groups of patients were created: the first (control, 30 patients), the second (30 patients) – nitric oxide was administered by inhalation during the entire operation, the third (33 patients) – nitric oxide was added into the sweep gas of the extracorporeal circuit. The level of troponin I (cTn I) was determined in the postoperative period – after transfer into the ICU, 12, 24 and 48 hours after the operation; studied clinical and functional indicators.

Results. Statistically lower levels of cTn I were revealed after transfer into the ICU, 12, 24 and 48 hours after surgery, a decrease in VIS, a shortening of stay in the ICU and the incidence of acute heart failure in patients of the 2nd and 3rd groups. There were no statistically significant differences between the method of inhalation and extracorporeal administration of nitric oxide.

Conclusions. Gaseous nitric oxide has a clinically pronounced cardioprotective effect and its effectiveness does not depend on the route of administration (inhalation or extracorporeal).

About Authors

  • Vladimir V. Pichugin, Dr. Med. Sci., Professor; ORCID
  • Stepan E. Domnin, Cand. Med. Sci., Anesthesiologist; ORCID
  • Evgeniy V. Sandalkin, Cand. Med. Sci., Associate Professor of Chair of Anesthesiology, Resuscitation and Transfusiology; ORCID
  • Mikhail V. Ryazanov, Cand. Med. Sci., Associate Professor of Chair of Hospital Surgery named after B.A. Korolev; ORCID
  • Valeriya V. Bober, Cand. Med. Sci., Associate Professor of Chair of Anesthesiology, Resuscitation and Transfusiology; ORCID

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