Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Central hemodynamics in off-pump coronary artery bypass operations

Authors: Khinchagov D.Ya., Rybka M.M., Golubev E.P., Mumladze K.V.

Company:
Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russian Federation

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DOI: https://doi.org/10.24022/1814-6910-2022-19-3-257-265

UDC: 616.132.2-089]:612.13

Link: Clinical Physiology of Blood Circulaiton. 2022; 3 (19): 257-265

Quote as: Khinchagov D.Ya., Rybka M.M., Golubev E.P., Mumladze K.V. Central hemodynamics in off-pump coronary artery bypass operations. Clinical Physiology of Circulation. 2022; 19 (3): 257–65 (in Russ.). DOI: 10.24022/1814-6910-2022-19-3-257-265

Received / Accepted:  14.07.2022 / 01.09.2022

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Abstract

Objective. Assess changes in hemodynamic parameters and vascular tone during coronary artery bypass grafting when positioning and bypassing the target artery during OPCAB. Selection of the optimal profile of cardiotonic support and infusion therapy, which allows minimizing hemodynamic instability.

Material and methods. A prospective study of 36 patients who underwent a primary elective OPCAB for coronary artery disease. The state of central hemodynamics was studied using a Swan-Ganz catheter. The selection of vasopressor, cardiotonic support and infusion therapy was carried out based on indicators of central hemodynamics.

Results. According to the results of our study, when bypassing the arteries of the anterior wall of the heart, there is a slight decrease in the cardiac index (CI) (from 2.5 to 2.1 l/min/m2) and a statistically significant decrease in stroke volume (SV) (from 80 to 64), while pulmonary capillary wedge pressure (PCWP) slightly increases, which indicates a significant development of hypokinesis with shunting of the anterior wall of the myocardium. When shunting the arteries of the lateral wall of the myocardium, there is a statistically significant decrease in SI, due to a decrease in the preload of the left ventricle, as evidenced by a statistically significant decrease in SV and a decrease in PCWP. When shunting the artery of the posterior wall of the heart, there is also a decrease in CI, SV, PCWP and a statistically significant increase in CVP, due to significant compression of the right ventricle.

Conclusion. Changes in central hemodynamic parameters obtained by the thermodilution method during heart positioning and coronary artery bypass grafting against the background of impaired filling processes of the heart chambers and transient myocardial ischemia are important for the successful implementation of OPCAB. Correction of hemodynamics with cardiotonic support, infusion therapy and Trendelenburg position allow for stable hemodynamics with improved visualization when positioning the heart for bypass of target coronary arteries and promote complete myocardial revascularization.

About Authors

  • Dzhumber Ya. Khinchagov, Cand. Med. Sci., Anesthesiologist-Intensivist; ORCID
  • Mikhail M. Rybka, Dr. Med. Sci., Head of Department of Anesthesiology and Intensive Care Unit; ORCID
  • Evgeniy P. Golubev, Cand. Med. Sci., Senior Research Associate; ORCID
  • Koba V. Mumladze, Anesthesiologist-Intensivist; ORCID

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