Научно-практический журнал
«Клиническая физиология кровообращения»

ISSN 1814-6910 (Print)
ISSN 2410-9134 (Online)

 

Главный редактор

Лео Антонович Бокерия, доктор медицинских наук, профессор, академик РАН и РАМН, президент ФГБУ «НМИЦ ССХ им. А.Н. Бакулева» МЗ РФ


Каталог статей ➤ КФК. 2023; 20 (3): 203-320 ➤ Роль «новых» биомаркеров системного воспаления в прогнозировании характера течения ишемической болезни сердца и результатов реваскуляризации миокарда

Роль «новых» биомаркеров системного воспаления в прогнозировании характера течения ишемической болезни сердца и результатов реваскуляризации миокарда

Авторы: Талибова С.М., Басиева М.А., Шварц В.А.

Организация:
ФГБУ «Национальный медицинский исследовательский центр сердечно-сосудистой хирургии им. А.Н. Бакулева» Минздрава России, Москва, Российская Федерация

Для корреспонденции: Сведения доступны для зарегистрированных пользователей.

Раздел: Обзоры

DOI: https://doi.org/10.24022/1814-6910-2023-20-3-221-230

УДК: 616.12-008.46-089

Библиографическая ссылка: Клиническая физиология кровообращения. 2023; 3 (20): 221-230

Цитировать как: Талибова С.М., Басиева М.А., Шварц В.А. . Роль «новых» биомаркеров системного воспаления в прогнозировании характера течения ишемической болезни сердца и результатов реваскуляризации миокарда. Клиническая физиология кровообращения. 2023; 3 (20): 221-230. DOI: 10.24022/1814-6910-2023-20-3-221-230

Ключевые слова: атеросклероз, воспаление, ишемическая болезнь сердца, «новые» биомаркеры системного воспаления, индекс системного воспаления, индекс системного воспалительного ответа, совокупный индекс системного воспаления

Поступила / Принята к печати:  12.07.2023 / 31.08.2023

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Аннотация

Одним из основных механизмов развития и прогрессирования ишемической болезни сердца (ИБС) служит атеросклероз коронарных артерий. Атеросклероз является хроническим воспалительным процессом, который характеризуется интенсивной иммунологической активностью, основной мишенью которого становятся артерии. Поскольку хроническое воспаление играет важную роль в патогенезе ИБС, провоспалительные маркеры имеют ключевое значение, отражая активность процесса. Согласно проведенным исследованиям доказана прогностическая роль уровней фибриногена, С-реактивного белка, маркеров семейства интерлейкинов (ИЛ-1, ИЛ-3, ИЛ-6, ИЛ-8, ИЛ-10), фактора некроза опухоли, лейкоцитов крови и других параметров с риском последующего развития атеросклероза артерий.

В мировой литературе опубликованы результаты научных исследований, описывающих «новые» биомаркеры системного воспаления: индекс системного воспаления (Systemic Inflammation Index – SII), индекс системного воспалительного ответа (Systemic Inflammation Response Index – SIRI) и совокупный индекс системного воспаления (Aggregate Index of Systemic Inflammation – AISI). Это гематологические индексы, которые основаны на количестве лейкоцитов крови и их подтипов. В данной статье рассматриваются исследования, посвященные оценке влияния этих маркеров системного воспаления на выраженность и течение ИБС, а также показывающие их прогностическую значимость в развитии неблагоприятных сердечно-сосудистых событий у пациентов со стабильной ИБС, с острым коронарным синдромом и после хирургической реваскуляризации миокарда.

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****
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Об авторах

  • Талибова Саялы Махмад кызы, аспирант, врач-кардиолог; ORCID
  • Басиева Мадина Альбертовна, аспирант, врач-кардиолог; ORCID
  • Шварц Владимир Александрович, д-р мед. наук, вед. науч. сотр., профессор кафедры сердечно-сосудистой хирургии с курсом аритмологии и клинической электрофизиологии; ORCID

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