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«Клиническая физиология кровообращения»

ISSN 1814-6910 (Print)
ISSN 2410-9134 (Online)

 

Главный редактор

Лео Антонович Бокерия, доктор медицинских наук, профессор, академик РАН и РАМН, президент ФГБУ «НМИЦ ССХ им. А.Н. Бакулева» МЗ РФ


Каталог статей ➤ КФК. 2021; 18 (2): 93-180 ➤ Генетические факторы риска развития периоперационного инфаркта миокарда. Часть 2

Генетические факторы риска развития периоперационного инфаркта миокарда. Часть 2

Авторы: Кокшенёва И.В., Закарая И.Т., Малороева А.И.

Организация:
ФГБУ «Национальный медицинский исследовательский центр сердечно-сосудистой хирургии им. А.Н. Бакулева» (президент – академик РАН и РАМН Л.А. Бокерия) Минздрава России, Рублевское ш., 135, Москва, 121552, Российская Федерация

Для корреспонденции: Сведения доступны для зарегистрированных пользователей.

Раздел: Обзоры

DOI: https://doi.org/10.24022/1814-6910-2021-18-2-109-117

УДК: 616.127-005.8:575

Библиографическая ссылка: Клиническая физиология кровообращения. 2021; 2 (18): 97-108

Цитировать как: Кокшенёва И.В., Закарая И.Т., Малороева А.И. . Генетические факторы риска развития периоперационного инфаркта миокарда. Часть 2. Клиническая физиология кровообращения. 2021; 2 (18): 97-108. DOI: 10.24022/1814-6910-2021-18-2-109-117

Ключевые слова: генетическая вариабельность, генетические варианты, ассоциированные с риском периоперационного инфаркта миокарда, генетическая вариабельность регуляторных путей воспалительной реакции, генетическая вариабельность регуляторных путей гемостаза, локус 9p21

Поступила / Принята к печати:  22.10.2020 / 11.11.2020

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Аннотация

Несмотря на совершенствование хирургических методов и защиты миокарда, анестезиологического пособия, развитие периоперационного инфаркта миокарда при кардиохирургических операциях остается нередким явлением и сочетается со снижением ближайшей и отдаленной выживаемости. В основе патофизиологии интраоперационного инфаркта миокарда при кардиохирургических операциях лежат три ведущих механизма: 1) системное и локальное воспаление; 2) нарушения в свертывающей системе крови; 3) нейроэндокринный стресс. Генетическая вариабельность присутствует в каждом из упомянутых регуляторных путей. Генетические варианты различных путей могут присутствовать у одного пациента, модулируя величину повреждения миокарда. В данном обзоре представлены опубликованные данные о выявленных генетических вариантах, связанных с периоперационным инфарктом миокарда у пациентов, перенесших кардиохирургические операции. В перспективе генетические исследования смогут помочь в предоперационной прогностической оценке риска развития инфаркта миокарда

Литература

  1. Mahaffey K.W., Roe M.T., Kilaru R., Alexander J.H., Van de Werf F., Califf R.M. et al. Creatine kinase-MB elevation after coronary artery bypass grafting surgery in patients with non-ST-segment elevation acute coronary syndromes predict worse outcomes: results from four large clinical trials. Eur. Heart. J. 2007; 28 (4): 425–32. DOI: 10.1093/eurheartj/ehl483
  2. Broeckel U., Hengstenberg C., Mayer B., Holmer S., Martin L.J., Comuzzie A.G. et al. A comprehensive linkage analysis for myocardial infarction and its related risk factors. Nat. Genet. 2002; 30 (2): 210–4. DOI: 10.1038/ng827
  3. Ozaki K., Tanaka T. Genome-wide association study to identify SNPs conferring risk of myocardial infarction and their functional analyses. Cell. Mol. Life. Sci. 2005; 62 (16): 1804–13. DOI: 10.1007/s00018-005-5098-z
  4. Hirokawa M., Morita H., Tajima T., Takahashi A., Ashikawa K., Miya F. et al. A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese. Eur. J. Hum. Genet. 2015; 23 (3): 374–80. DOI: 10.1038/ejhg.2014.110
  5. Ozaki K., Tanaka T. Molecular genetics of coronary artery disease. J. Hum. Genet. 2016; 61 (1): 71–7. DOI: 10.1038/jhg.2015.70
  6. Podgoreanu M.V., Schwinn D.A. New paradigms in cardiovascular medicine: emerging technologies and practices: perioperative genomics. J. Am. Coll. Cardiol. 2005; 6; 46 (11): 1965–77. DOI: 10.1016/j.jacc. 2005.08.040
  7. Бузиашвили Ю.И., Кокшенева И.В., Шахназарян Л.С., Самсонова Н.Н., Климович Л.Г., Бузиашвили В.Ю. и др. Функциональное состояние миокарда в раннем послеоперационном периоде при различных методиках коронарного шунтирования, роль механизмов апоптоза. Кардиология и сердечнососудистая хирургия. 2015; 8 (5): 14–25.
  8. Бузиашвили Ю.И., Кокшенева И.В., Абуков С.Т., Сандухадзе Б.Р. Значение генетического полиморфизма медиаторов воспалительного ответа в развитии осложнений после кардиохирургических операций (обзор литературы). Кардиология и сердечнососудистая хирургия. 2016; 9 (1): 13–9.
  9. Podgoreanu M.V., White W.D., Morris R.W., Mathew J.P., Stafford-Smith M., Welsby I.J. et al.; Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery. Circulation. 2006; 114 (Suppl. 1): I275–81. DOI: 10.1161/CIRCULATIONAHA.105.001032
  10. Collard C.D., Shernan S.K., Fox A.A., Bernig T., Chanock S.J., Vaughn W.K. et al. The MBL2 'LYQA secretor' haplotype is an independent predictor of postoperative myocardial infarction in whites undergoing coronary artery bypass graft surgery. Circulation. 2007; 116 (Suppl. 11): I106–12. DOI: 10.1161/CIRCULATIONAHA.106.679530
  11. Shaw A.D., Vaporciyan A.A., Wu X., King T.M., Spitz M.R., Putnam J.B., Dickey B.F. Inflammatory gene polymorphisms influence risk of postoperative morbidity after lung resection. Ann. Thorac. Surg. 2005; 79 (5): 1704–10. DOI: 10.1016/j.athoracsur.2004.10.010
  12. Brull D.J., Montgomery H.E., Sanders J., Dhamrait S., Luong L., Rumley A. et al. Interleukin-6 gene -174g>c and -572g>c promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery. Arterioscler. Thromb. Vasc. Biol. 2001; 21 (9): 1458–63. DOI: 10.1161/hq0901.094280
  13. Grocott H.P., Newman M.F., El-Moalem H., Bainbridge D., Butler A., Laskowitz D.T. Apolipoprotein E genotype differentially influences the proinflammatory and anti-inflammatory response to cardiopulmonary bypass. J. Thorac. Cardiovasc. Surg. 2001; 122 (3): 622–3. DOI: 10.1067/mtc.2001.115152
  14. Roth-Isigkeit A., Hasselbach L., Ocklitz E., Brückner S., Ros A., Gehring H. et al. Inter-individual differences in cytokine release in patients undergoing cardiac surgery with cardiopulmonary bypass. Clin. Exp. Immunol. 2001; 125 (1): 80–8. DOI: 10.1046/j.1365- 2249.2001.01521.x
  15. Lehmann L.E., Schroeder S., Hartmann W., Dewald O., Book M., Weber S.U. et al. A single nucleotide polymorphism of macrophage migration inhibitory factor is related to inflammatory response in coronary bypass surgery using cardiopulmonary bypass. Eur. J. Cardiothorac. Surg. 2006; 30 (1): 59–63. DOI: 10.1016/j.ejcts.2006.01.058
  16. Tomasdottir H., Hjartarson H., Ricksten A., Wasslavik C., Bengtsson A., Ricksten S.E. Tumor necrosis factor gene polymorphism is associated with enhanced systemic inflammatory response and increased cardiopulmonary morbidity after cardiac surgery. Anesth. Analg. 2003; 97 (4): 944–9. DOI: 10.1213/01.ane. 0000078574.76915.11
  17. Galley H.F., Lowe P.R., Carmichael R.L., Webster N.R. Genotype and interleukin-10 responses after cardiopulmonary bypass. Br. J. Anaesth. 2003; 91 (3): 424–6. DOI: 10.1093/bja/aeg174
  18. Kertai M.D., Li Y.J., Li Y.W., Ji Y., Alexander J., Newman M.F. et al.; Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team. Genome-wide association study of perioperative myocardial infarction after coronary artery bypass surgery. BMJ Open. 2015; 5 (5): e006920. DOI: 10.1136/bmjopen-2014-006920
  19. Rifón J., Páramo J.A., Panizo C., Montes R., Rocha E. The increase of plasminogen activator inhibitor activity is associated with graft occlusion in patients undergoing aorto-coronary bypass surgery. Br. J. Haematol. 1997; 99 (2): 262–7. DOI: 10.1046/j.1365-2141.1997.3913205.x
  20. Parolari A., Poggio P., Myasoedova V., Songia P., Bonalumi G., Pilozzi A. et al. Biomarkers in coronary artery bypass surgery: ready for prime time and outcome prediction? Front. Cardiovasc. Med. 2016; 2: 39. DOI: 10.3389/fcvm.2015.00039
  21. Girelli D., Russo C., Ferraresi P., Olivieri O., Pinotti M., Friso S. et al. Polymorphisms in the factor VII gene and the risk of myocardial infarction in patients with coronary artery disease. N. Engl. J. Med. 2000; 343 (11): 774–80. DOI: 10.1056/NEJM200009143431104
  22. Campo G., Valgimigli M., Ferraresi P., Malagutti P., Baroni M., Arcozzi C. et al. Tissue factor and coagulation factor VII levels during acute myocardial infarction: association with genotype and adverse events. Arterioscler. Thromb. Vasc. Biol. 2006; 26 (12): 2800–6. DOI: 10.1161/01.ATV.0000247249.82030.94
  23. Sakowicz A., Fendler W., Lelonek M., Gluba A., Pietrucha T. Two polymorphisms of the FVII gene and their impact on the risk of myocardial infarction in poles under 45 years of age. Mol. Biol. (Mosk). 2010; 44 (2): 229–34.
  24. Rinder Ch.S., Mathew J.P., Rinder H.M., Howe J.G., Fontes M., Crouch J. et al.; Multicenter Study of Perioperative Ischemia Research Group. Platelet PlA2 polymorphism and platelet activation are associated with increased troponin I release after cardiopulmonary bypass. Anesthesiology. 2002; 97 (5): 1118–22. DOI: 10.1097/00000542-200211000-00013
  25. Zotz R.B., Klein M., Dauben H.P., Moser C., Gams E., Scharf R.E. Prospective analysis after coronary-artery bypass grafting: platelet GP IIIa polymorphism (HPA1b/PIA2) is a risk factor for bypass occlusion, myocardial infarction, and death. Thromb. Haemost. 2000; 83 (3): 404–7.
  26. Faraday N., Martinez E.A., Scharpf R.B., KaschSemenza L., Dorman T., Pronovost P.J. et al. Platelet gene polymorphisms and cardiac risk assessment in vascular surgical patients. Anesthesiology. 2004; 101 (6): 1291–7. DOI: 10.1097/00000542-200412000-00008
  27. Donahue B.S. Factor V Leiden and perioperative risk. Anesth. Analg. 2004; 98 (6): 1623–34. DOI: 10.1213/01.ane.0000113545.03192.fd
  28. Donahue B.S., Gailani D., Higgins M.S., Drinkwater D.C., George A.L. Jr. Factor V Leiden protects against blood loss and transfusion after cardiac surgery. Circulation. 2003; 107 (7): 1003–8. DOI: 10.1161/01.cir.0000051864.28048.01
  29. Moor E., Silveira A., van't Hooft F., Tornvall P., Blombäck M., Wiman B. et al. Coagulation factor V (Arg506–>Gln) mutation and early saphenous vein graft occlusion after coronary artery bypass grafting. Thromb. Haemost. 1998; 80 (2): 220–4.
  30. McPherson R., Pertsemlidis A., Kavaslar N., Stewart A., Roberts R., Cox D.R. et al. A common allele on chromosome 9 associated with coronary heart disease. Science. 2007; 316 (5830): 1488–91. DOI: 10.1126/science.1142447
  31. Liu K.Y., Muehlschlegel J.D., Perry T.E., Fox A.A., Collard C.D., Body S.C., Shernan S.K.J. Common genetic variants on chromosome 9p21 predict perioperative myocardial injury after coronary artery bypass graft surgery. Thorac. Cardiovasc. Surg. 2010; 139 (2): 483–8. DOI: 10.1016/j.jtcvs.2009.06.032
  32. Liu Y., Sanoff H.K., Cho H., Burd Ch.E., Torrice C., Mohlke K.L. et al. INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis. PLoS. One. 2009; 4 (4): e5027. DOI: 10.1371/journal.pone.0005027
  33. Pasmant E., Laurendeau I., Háron D., Vidaud M., Vidaud D., Biéche I. Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF. Cancer. Res. 2007; 67 (8): 3963–9. DOI: 10.1158/0008-5472.CAN-06-2004
  34. Ye S., Willeit J., Kronenberg F., Xu Q., Kiechl S. Association of genetic variation on chro.mos.ome 9p21 with susceptibility and progression of atherosclerosis: a population-based, prospective study. J. Am. Coll. Cardiol. 2008; 52 (5): 378–84. DOI: 10.1016/j.jacc.2007.11.0
  35. Thompson A.R., Drenos F., Hafez H., Humphries S.E. Candidate gene association studies in abdominal aortic aneurysm disease: a review and meta-analysis. Eur. J. Vasc. Endovasc. Surg. 2008; 35 (1): 19–30. DOI: 10.1016/j.ejvs.2007.07.022
  36. Muehlschlegel J.D., Liu K.Y., Perry T.E., Fox A.A., Collard Ch.D., Shernan S.K., Body S., CABG Genomics Investigators. Chromosome 9p21 variant predicts mortality after coronary artery bypass graft surgery. Circulation. 2010; 122 (Suppl. 11): S60–5. DOI: 10.1161/CIRCULATIONAHA.109.924233
  37. Granger A., Abdullah I., Huebner F., Stout A., Wang T., Huebner T. et al. Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice. FASEB. J. 2008; 22 (10): 3549–60. DOI: 10.1096/fj.08-108548
  38. Kempf T., Eden M., Strelau J., Naguib M., Willenbockel C., Tongers J. et al. The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury. Circ. Res. 2006; 98 (3): 351–60. DOI: 10.1161/01.RES.0000202805.73038.48
  39. Zaugg M., Bestmann L., Wacker J., Lucchinetti E., Boltres A., Schulz C. et al. Adrenergic receptor genotype but not perioperative bisoprolol therapy may determine cardiovascular outcome in at-risk patients undergoing surgery with spinal block: the Swiss Beta Blocker in Spinal Anesthesia (BBSA) study: a double-blinded, placebo-controlled, multicenter trial with 1-year follow-up. Anesthesiology. 2007; 107 (1): 33–44. DOI: 10.1097/01.anes.0000267530.62344.a4
  40. Lasocki S., Iglarz M., Seince P.F., Vuillaumier-Barrot S., Vicaut E., Henrion D. et al. Involvement of renin-angiotensin system in pressure-flow relationship: role of angiotensin-converting enzyme gene polymorphism. Anesthesiology. 2002; 96 (2): 271–5. DOI: 10.1097/00000542-200202000-00008
  41. Ryan R., Thornton J., Duggan E., McGovern E., O’Dwyer M.J., Ryan A.W. et al. Gene polymorphism and requirement for vasopressor infusion after cardiac surgery. Ann. Thorac. Surg. 2006; 82 (3): 895–901. DOI: 10.1016/j.athoracsur.2006.04.029
****
  1. Mahaffey K.W., Roe M.T., Kilaru R., Alexander J.H., Van de Werf F., Califf R.M. et al. Creatine kinase-MB elevation after coronary artery bypass grafting surgery in patients with non-ST-segment elevation acute coronary syndromes predict worse outcomes: results from four large clinical trials. Eur. Heart. J. 2007; 28 (4): 425–32. DOI: 10.1093/eurheartj/ehl483
  2. Broeckel U., Hengstenberg C., Mayer B., Holmer S., Martin L.J., Comuzzie A.G. et al. A comprehensive linkage analysis for myocardial infarction and its related risk factors. Nat. Genet. 2002; 30 (2): 210–4. DOI: 10.1038/ng827
  3. Ozaki K., Tanaka T. Genome-wide association study to identify SNPs conferring risk of myocardial infarction and their functional analyses. Cell. Mol. Life. Sci. 2005; 62 (16): 1804–13. DOI: 10.1007/s00018-005-5098-z
  4. Hirokawa M., Morita H., Tajima T., Takahashi A., Ashikawa K., Miya F. et al. A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese. Eur. J. Hum. Genet. 2015; 23 (3): 374–80. DOI: 10.1038/ejhg.2014.110
  5. Ozaki K., Tanaka T. Molecular genetics of coronary artery disease. J. Hum. Genet. 2016; 61 (1): 71–7. DOI: 10.1038/jhg.2015.70
  6. Podgoreanu M.V., Schwinn D.A. New paradigms in cardiovascular medicine: emerging technologies and practices: perioperative genomics. J. Am. Coll. Cardiol. 2005; 6; 46 (11): 1965–77. DOI: 10.1016/j.jacc. 2005.08.040
  7. Buziashvili Yu.I., Koksheneva I.V., Shakhnazaryan L.S., Samsonova N.N., Klimovich L.G., Buziashvili V.Yu. et al. The functional state of the myocardium in the early postoperative period with various methods of coronary artery bypass grafting, the role of apoptosis mechanisms. Cardiology and Cardiovascular Surgery. 2015; 8 (5): 14–25 (in Russ.).
  8. Buziashvili Yu.I., Koksheneva I.V., Abukov S.T., Sandukhadze B.R. The value of genetic polymorphism of inflammatory response mediators in the development of complications after cardiac surgery (literature review). Cardiology and Cardiovascular Surgery. 2016; 9 (1): 13–9 (in Russ.).
  9. Podgoreanu M.V., White W.D., Morris R.W., Mathew J.P., Stafford-Smith M., Welsby I.J. et al.; Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery. Circulation. 2006; 114 (Suppl. 1): I275–81. DOI: 10.1161/CIRCULATIONAHA.105.001032
  10. Collard C.D., Shernan S.K., Fox A.A., Bernig T., Chanock S.J., Vaughn W.K. et al. The MBL2 'LYQA secretor' haplotype is an independent predictor of postoperative myocardial infarction in whites undergoing coronary artery bypass graft surgery. Circulation. 2007; 116 (Suppl. 11): I106–12. DOI: 10.1161/CIRCULATIONAHA.106.679530
  11. Shaw A.D., Vaporciyan A.A., Wu X., King T.M., Spitz M.R., Putnam J.B., Dickey B.F. Inflammatory gene polymorphisms influence risk of postoperative morbidity after lung resection. Ann. Thorac. Surg. 2005; 79 (5): 1704–10. DOI: 10.1016/j.athoracsur.2004.10.010
  12. Brull D.J., Montgomery H.E., Sanders J., Dhamrait S., Luong L., Rumley A. et al. Interleukin-6 gene -174g>c and -572g>c promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery. Arterioscler. Thromb. Vasc. Biol. 2001; 21 (9): 1458–63. DOI: 10.1161/hq0901.094280
  13. Grocott H.P., Newman M.F., El-Moalem H., Bainbridge D., Butler A., Laskowitz D.T. Apolipoprotein E genotype differentially influences the proinflammatory and anti-inflammatory response to cardiopulmonary bypass. J. Thorac. Cardiovasc. Surg. 2001; 122 (3): 622–3. DOI: 10.1067/mtc.2001.115152
  14. Roth-Isigkeit A., Hasselbach L., Ocklitz E., Brückner S., Ros A., Gehring H. et al. Inter-individual differences in cytokine release in patients undergoing cardiac surgery with cardiopulmonary bypass. Clin. Exp. Immunol. 2001; 125 (1): 80–8. DOI: 10.1046/j.1365- 2249.2001.01521.x
  15. Lehmann L.E., Schroeder S., Hartmann W., Dewald O., Book M., Weber S.U. et al. A single nucleotide polymorphism of macrophage migration inhibitory factor is related to inflammatory response in coronary bypass surgery using cardiopulmonary bypass. Eur. J. Cardiothorac. Surg. 2006; 30 (1): 59–63. DOI: 10.1016/j.ejcts.2006.01.058
  16. Tomasdottir H., Hjartarson H., Ricksten A., Wasslavik C., Bengtsson A., Ricksten S.E. Tumor necrosis factor gene polymorphism is associated with enhanced systemic inflammatory response and increased cardiopulmonary morbidity after cardiac surgery. Anesth. Analg. 2003; 97 (4): 944–9. DOI: 10.1213/01.ane. 0000078574.76915.11
  17. Galley H.F., Lowe P.R., Carmichael R.L., Webster N.R. Genotype and interleukin-10 responses after cardiopulmonary bypass. Br. J. Anaesth. 2003; 91 (3): 424–6. DOI: 10.1093/bja/aeg174
  18. Kertai M.D., Li Y.J., Li Y.W., Ji Y., Alexander J., Newman M.F. et al.; Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team. Genome-wide association study of perioperative myocardial infarction after coronary artery bypass surgery. BMJ Open. 2015; 5 (5): e006920. DOI: 10.1136/bmjopen-2014-006920
  19. Rifón J., Páramo J.A., Panizo C., Montes R., Rocha E. The increase of plasminogen activator inhibitor activity is associated with graft occlusion in patients undergoing aorto-coronary bypass surgery. Br. J. Haematol. 1997; 99 (2): 262–7. DOI: 10.1046/j.1365-2141.1997.3913205.x
  20. Parolari A., Poggio P., Myasoedova V., Songia P., Bonalumi G., Pilozzi A. et al. Biomarkers in coronary artery bypass surgery: ready for prime time and outcome prediction? Front. Cardiovasc. Med. 2016; 2: 39. DOI: 10.3389/fcvm.2015.00039
  21. Girelli D., Russo C., Ferraresi P., Olivieri O., Pinotti M., Friso S. et al. Polymorphisms in the factor VII gene and the risk of myocardial infarction in patients with coronary artery disease. N. Engl. J. Med. 2000; 343 (11): 774–80. DOI: 10.1056/NEJM200009143431104
  22. Campo G., Valgimigli M., Ferraresi P., Malagutti P., Baroni M., Arcozzi C. et al. Tissue factor and coagulation factor VII levels during acute myocardial infarction: association with genotype and adverse events. Arterioscler. Thromb. Vasc. Biol. 2006; 26 (12): 2800–6. DOI: 10.1161/01.ATV.0000247249.82030.94
  23. Sakowicz A., Fendler W., Lelonek M., Gluba A., Pietrucha T. Two polymorphisms of the FVII gene and their impact on the risk of myocardial infarction in poles under 45 years of age. Mol. Biol. (Mosk). 2010; 44 (2): 229–34.
  24. Rinder Ch.S., Mathew J.P., Rinder H.M., Howe J.G., Fontes M., Crouch J. et al.; Multicenter Study of Perioperative Ischemia Research Group. Platelet PlA2 polymorphism and platelet activation are associated with increased troponin I release after cardiopulmonary bypass. Anesthesiology. 2002; 97 (5): 1118–22. DOI: 10.1097/00000542-200211000-00013
  25. Zotz R.B., Klein M., Dauben H.P., Moser C., Gams E., Scharf R.E. Prospective analysis after coronary-artery bypass grafting: platelet GP IIIa polymorphism (HPA1b/PIA2) is a risk factor for bypass occlusion, myocardial infarction, and death. Thromb. Haemost. 2000; 83 (3): 404–7.
  26. Faraday N., Martinez E.A., Scharpf R.B., KaschSemenza L., Dorman T., Pronovost P.J. et al. Platelet gene polymorphisms and cardiac risk assessment in vascular surgical patients. Anesthesiology. 2004; 101 (6): 1291–7. DOI: 10.1097/00000542-200412000-00008
  27. Donahue B.S. Factor V Leiden and perioperative risk. Anesth. Analg. 2004; 98 (6): 1623–34. DOI: 10.1213/01.ane.0000113545.03192.fd
  28. Donahue B.S., Gailani D., Higgins M.S., Drinkwater D.C., George A.L. Jr. Factor V Leiden protects against blood loss and transfusion after cardiac surgery. Circulation. 2003; 107 (7): 1003–8. DOI: 10.1161/01.cir.0000051864.28048.01
  29. Moor E., Silveira A., van't Hooft F., Tornvall P., Blombäck M., Wiman B. et al. Coagulation factor V (Arg506–>Gln) mutation and early saphenous vein graft occlusion after coronary artery bypass grafting. Thromb. Haemost. 1998; 80 (2): 220–4.
  30. McPherson R., Pertsemlidis A., Kavaslar N., Stewart A., Roberts R., Cox D.R. et al. A common allele on chromosome 9 associated with coronary heart disease. Science. 2007; 316 (5830): 1488–91. DOI: 10.1126/science.1142447
  31. Liu K.Y., Muehlschlegel J.D., Perry T.E., Fox A.A., Collard C.D., Body S.C., Shernan S.K.J. Common genetic variants on chromosome 9p21 predict perioperative myocardial injury after coronary artery bypass graft surgery. Thorac. Cardiovasc. Surg. 2010; 139 (2): 483–8. DOI: 10.1016/j.jtcvs.2009.06.032
  32. Liu Y., Sanoff H.K., Cho H., Burd Ch.E., Torrice C., Mohlke K.L. et al. INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis. PLoS. One. 2009; 4 (4): e5027. DOI: 10.1371/journal.pone.0005027
  33. Pasmant E., Laurendeau I., Háron D., Vidaud M., Vidaud D., Biéche I. Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF. Cancer. Res. 2007; 67 (8): 3963–9. DOI: 10.1158/0008-5472.CAN-06-2004
  34. Ye S., Willeit J., Kronenberg F., Xu Q., Kiechl S. Association of genetic variation on chro.mos.ome 9p21 with susceptibility and progression of atherosclerosis: a population-based, prospective study. J. Am. Coll. Cardiol. 2008; 52 (5): 378–84. DOI: 10.1016/j.jacc.2007.11.0
  35. Thompson A.R., Drenos F., Hafez H., Humphries S.E. Candidate gene association studies in abdominal aortic aneurysm disease: a review and meta-analysis. Eur. J. Vasc. Endovasc. Surg. 2008; 35 (1): 19–30. DOI: 10.1016/j.ejvs.2007.07.022
  36. Muehlschlegel J.D., Liu K.Y., Perry T.E., Fox A.A., Collard Ch.D., Shernan S.K., Body S., CABG Genomics Investigators. Chromosome 9p21 variant predicts mortality after coronary artery bypass graft surgery. Circulation. 2010; 122 (Suppl. 11): S60–5. DOI: 10.1161/CIRCULATIONAHA.109.924233
  37. Granger A., Abdullah I., Huebner F., Stout A., Wang T., Huebner T. et al. Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice. FASEB. J. 2008; 22 (10): 3549–60. DOI: 10.1096/fj.08-108548
  38. Kempf T., Eden M., Strelau J., Naguib M., Willenbockel C., Tongers J. et al. The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury. Circ. Res. 2006; 98 (3): 351–60. DOI: 10.1161/01.RES.0000202805.73038.48
  39. Zaugg M., Bestmann L., Wacker J., Lucchinetti E., Boltres A., Schulz C. et al. Adrenergic receptor genotype but not perioperative bisoprolol therapy may determine cardiovascular outcome in at-risk patients undergoing surgery with spinal block: the Swiss Beta Blocker in Spinal Anesthesia (BBSA) study: a double-blinded, placebo-controlled, multicenter trial with 1-year follow-up. Anesthesiology. 2007; 107 (1): 33–44. DOI: 10.1097/01.anes.0000267530.62344.a4
  40. Lasocki S., Iglarz M., Seince P.F., Vuillaumier-Barrot S., Vicaut E., Henrion D. et al. Involvement of renin-angiotensin system in pressure-flow relationship: role of angiotensin-converting enzyme gene polymorphism. Anesthesiology. 2002; 96 (2): 271–5. DOI: 10.1097/00000542-200202000-00008
  41. Ryan R., Thornton J., Duggan E., McGovern E., O’Dwyer M.J., Ryan A.W. et al. Gene polymorphism and requirement for vasopressor infusion after cardiac surgery. Ann. Thorac. Surg. 2006; 82 (3): 895–901. DOI: 10.1016/j.athoracsur.2006.04.029

Об авторах

  • Кокшенёва Инна Валериевна, доктор мед. наук, ст. науч. сотр.; ORCID
  • Закарая Ираклий Темурович, мл. науч. сотр.
  • Малороева Амина Исаевна, аспирант

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