Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Genetic risk factors of perioperative myocardial infarction. Part 2

Authors: Koksheneva I.V., Zakaraya I.T., Maloroeva A.I.

Company:
Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, 121552, Russian Federation

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DOI: https://doi.org/10.24022/1814-6910-2021-18-2-109-117

UDC: 616.127-005.8:575

Link: Clinical Physiology of Blood Circulaiton. 2021; 2 (18): 97-108

Quote as: Koksheneva I.V., Zakaraya I.T., Maloroeva A.I. Genetic risk factors of perioperative myocardial infarction. Part 2. Clinical Physiology of Circulation. 2021; 18 (2): 109–17 (in Russ.). DOI: 10.24022/1814-6910-2021-18-2-109-117

Received / Accepted:  22.10.2020 / 11.11.2020

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Abstract

Despite the improvement of surgical methods and protection of the myocardium, anesthesia, the development of perioperative myocardial infarction during cardiac surgery remains a common occurrence and is combined with a decrease in the immediate and distant survival. The pathophysiology of intraoperative myocardial infarction in cardiac surgery is based on three leading mechanisms: 1) systemic and local inflammation; 2) disorders in the blood coagulation system; 3) neuroendocrine stress. Genetic variability is present in each of these regulatory pathways. Genetic variants of different pathways may be present in the same patient, modulating the amount of myocardial injury. This review presents the published data on identified genetic variants associated with perioperative myocardial infarction in patients undergoing cardiac surgery. In the future, genetic studies can help in the preoperative prognostic assessment of the risk of myocardial infarction.

About Authors

  • Inna V. Koksheneva, Dr. Med. Sc., Senior Researcher; ORCID
  • Irakliy T. Zakaraya, Junior Researcher
  • Amina I. Maloroeva, Postgraduate

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