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«Клиническая физиология кровообращения»

Главный редактор

Лео Антонович Бокерия, доктор медицинских наук, профессор, академик РАН и РАМН, директор ФГБУ «НМИЦССХ им. А.Н. Бакулева» МЗ РФ

Генетические факторы риска развития периоперационного инфаркта миокарда. Часть 2

Авторы: Кокшенёва И.В., Закарая И.Т., Малороева А.И.

Организация:
ФГБУ «Национальный медицинский исследовательский центр сердечно-сосудистой хирургии им. А.Н. Бакулева» (президент – академик РАН и РАМН Л.А. Бокерия) Минздрава России, Рублевское ш., 135, Москва, 121552, Российская Федерация

Для корреспонденции: Сведения доступны для зарегистрированных пользователей.

Раздел: Обзоры

DOI: https://doi.org/10.24022/1814-6910-2021-18-2-109-117

УДК: 616.127-005.8:575

Библиографическая ссылка: Клиническая физиология кровообращения. 2021; 2 (18): 97-108

Цитировать как: Кокшенёва И.В., Закарая И.Т., Малороева А.И. . Генетические факторы риска развития периоперационного инфаркта миокарда. Часть 2. Клиническая физиология кровообращения. 2021; 2 (18): 97-108. DOI: 10.24022/1814-6910-2021-18-2-109-117

Ключевые слова: генетическая вариабельность, генетические варианты, ассоциированные с риском периоперационного инфаркта миокарда, генетическая вариабельность регуляторных путей воспалительной реакции, генетическая вариабельность регуляторных путей гемостаза, локус 9p21

Поступила / Принята к печати:  22.10.2020 / 11.11.2020

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Аннотация

Несмотря на совершенствование хирургических методов и защиты миокарда, анестезиологического пособия, развитие периоперационного инфаркта миокарда при кардиохирургических операциях остается нередким явлением и сочетается со снижением ближайшей и отдаленной выживаемости. В основе патофизиологии интраоперационного инфаркта миокарда при кардиохирургических операциях лежат три ведущих механизма: 1) системное и локальное воспаление; 2) нарушения в свертывающей системе крови; 3) нейроэндокринный стресс. Генетическая вариабельность присутствует в каждом из упомянутых регуляторных путей. Генетические варианты различных путей могут присутствовать у одного пациента, модулируя величину повреждения миокарда. В данном обзоре представлены опубликованные данные о выявленных генетических вариантах, связанных с периоперационным инфарктом миокарда у пациентов, перенесших кардиохирургические операции. В перспективе генетические исследования смогут помочь в предоперационной прогностической оценке риска развития инфаркта миокарда

Литература

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****
  1. Mahaffey K.W., Roe M.T., Kilaru R., Alexander J.H., Van de Werf F., Califf R.M. et al. Creatine kinase-MB elevation after coronary artery bypass grafting surgery in patients with non-ST-segment elevation acute coronary syndromes predict worse outcomes: results from four large clinical trials. Eur. Heart. J. 2007; 28 (4): 425–32. DOI: 10.1093/eurheartj/ehl483
  2. Broeckel U., Hengstenberg C., Mayer B., Holmer S., Martin L.J., Comuzzie A.G. et al. A comprehensive linkage analysis for myocardial infarction and its related risk factors. Nat. Genet. 2002; 30 (2): 210–4. DOI: 10.1038/ng827
  3. Ozaki K., Tanaka T. Genome-wide association study to identify SNPs conferring risk of myocardial infarction and their functional analyses. Cell. Mol. Life. Sci. 2005; 62 (16): 1804–13. DOI: 10.1007/s00018-005-5098-z
  4. Hirokawa M., Morita H., Tajima T., Takahashi A., Ashikawa K., Miya F. et al. A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese. Eur. J. Hum. Genet. 2015; 23 (3): 374–80. DOI: 10.1038/ejhg.2014.110
  5. Ozaki K., Tanaka T. Molecular genetics of coronary artery disease. J. Hum. Genet. 2016; 61 (1): 71–7. DOI: 10.1038/jhg.2015.70
  6. Podgoreanu M.V., Schwinn D.A. New paradigms in cardiovascular medicine: emerging technologies and practices: perioperative genomics. J. Am. Coll. Cardiol. 2005; 6; 46 (11): 1965–77. DOI: 10.1016/j.jacc. 2005.08.040
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  9. Podgoreanu M.V., White W.D., Morris R.W., Mathew J.P., Stafford-Smith M., Welsby I.J. et al.; Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery. Circulation. 2006; 114 (Suppl. 1): I275–81. DOI: 10.1161/CIRCULATIONAHA.105.001032
  10. Collard C.D., Shernan S.K., Fox A.A., Bernig T., Chanock S.J., Vaughn W.K. et al. The MBL2 'LYQA secretor' haplotype is an independent predictor of postoperative myocardial infarction in whites undergoing coronary artery bypass graft surgery. Circulation. 2007; 116 (Suppl. 11): I106–12. DOI: 10.1161/CIRCULATIONAHA.106.679530
  11. Shaw A.D., Vaporciyan A.A., Wu X., King T.M., Spitz M.R., Putnam J.B., Dickey B.F. Inflammatory gene polymorphisms influence risk of postoperative morbidity after lung resection. Ann. Thorac. Surg. 2005; 79 (5): 1704–10. DOI: 10.1016/j.athoracsur.2004.10.010
  12. Brull D.J., Montgomery H.E., Sanders J., Dhamrait S., Luong L., Rumley A. et al. Interleukin-6 gene -174g>c and -572g>c promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery. Arterioscler. Thromb. Vasc. Biol. 2001; 21 (9): 1458–63. DOI: 10.1161/hq0901.094280
  13. Grocott H.P., Newman M.F., El-Moalem H., Bainbridge D., Butler A., Laskowitz D.T. Apolipoprotein E genotype differentially influences the proinflammatory and anti-inflammatory response to cardiopulmonary bypass. J. Thorac. Cardiovasc. Surg. 2001; 122 (3): 622–3. DOI: 10.1067/mtc.2001.115152
  14. Roth-Isigkeit A., Hasselbach L., Ocklitz E., Brückner S., Ros A., Gehring H. et al. Inter-individual differences in cytokine release in patients undergoing cardiac surgery with cardiopulmonary bypass. Clin. Exp. Immunol. 2001; 125 (1): 80–8. DOI: 10.1046/j.1365- 2249.2001.01521.x
  15. Lehmann L.E., Schroeder S., Hartmann W., Dewald O., Book M., Weber S.U. et al. A single nucleotide polymorphism of macrophage migration inhibitory factor is related to inflammatory response in coronary bypass surgery using cardiopulmonary bypass. Eur. J. Cardiothorac. Surg. 2006; 30 (1): 59–63. DOI: 10.1016/j.ejcts.2006.01.058
  16. Tomasdottir H., Hjartarson H., Ricksten A., Wasslavik C., Bengtsson A., Ricksten S.E. Tumor necrosis factor gene polymorphism is associated with enhanced systemic inflammatory response and increased cardiopulmonary morbidity after cardiac surgery. Anesth. Analg. 2003; 97 (4): 944–9. DOI: 10.1213/01.ane. 0000078574.76915.11
  17. Galley H.F., Lowe P.R., Carmichael R.L., Webster N.R. Genotype and interleukin-10 responses after cardiopulmonary bypass. Br. J. Anaesth. 2003; 91 (3): 424–6. DOI: 10.1093/bja/aeg174
  18. Kertai M.D., Li Y.J., Li Y.W., Ji Y., Alexander J., Newman M.F. et al.; Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team. Genome-wide association study of perioperative myocardial infarction after coronary artery bypass surgery. BMJ Open. 2015; 5 (5): e006920. DOI: 10.1136/bmjopen-2014-006920
  19. Rifón J., Páramo J.A., Panizo C., Montes R., Rocha E. The increase of plasminogen activator inhibitor activity is associated with graft occlusion in patients undergoing aorto-coronary bypass surgery. Br. J. Haematol. 1997; 99 (2): 262–7. DOI: 10.1046/j.1365-2141.1997.3913205.x
  20. Parolari A., Poggio P., Myasoedova V., Songia P., Bonalumi G., Pilozzi A. et al. Biomarkers in coronary artery bypass surgery: ready for prime time and outcome prediction? Front. Cardiovasc. Med. 2016; 2: 39. DOI: 10.3389/fcvm.2015.00039
  21. Girelli D., Russo C., Ferraresi P., Olivieri O., Pinotti M., Friso S. et al. Polymorphisms in the factor VII gene and the risk of myocardial infarction in patients with coronary artery disease. N. Engl. J. Med. 2000; 343 (11): 774–80. DOI: 10.1056/NEJM200009143431104
  22. Campo G., Valgimigli M., Ferraresi P., Malagutti P., Baroni M., Arcozzi C. et al. Tissue factor and coagulation factor VII levels during acute myocardial infarction: association with genotype and adverse events. Arterioscler. Thromb. Vasc. Biol. 2006; 26 (12): 2800–6. DOI: 10.1161/01.ATV.0000247249.82030.94
  23. Sakowicz A., Fendler W., Lelonek M., Gluba A., Pietrucha T. Two polymorphisms of the FVII gene and their impact on the risk of myocardial infarction in poles under 45 years of age. Mol. Biol. (Mosk). 2010; 44 (2): 229–34.
  24. Rinder Ch.S., Mathew J.P., Rinder H.M., Howe J.G., Fontes M., Crouch J. et al.; Multicenter Study of Perioperative Ischemia Research Group. Platelet PlA2 polymorphism and platelet activation are associated with increased troponin I release after cardiopulmonary bypass. Anesthesiology. 2002; 97 (5): 1118–22. DOI: 10.1097/00000542-200211000-00013
  25. Zotz R.B., Klein M., Dauben H.P., Moser C., Gams E., Scharf R.E. Prospective analysis after coronary-artery bypass grafting: platelet GP IIIa polymorphism (HPA1b/PIA2) is a risk factor for bypass occlusion, myocardial infarction, and death. Thromb. Haemost. 2000; 83 (3): 404–7.
  26. Faraday N., Martinez E.A., Scharpf R.B., KaschSemenza L., Dorman T., Pronovost P.J. et al. Platelet gene polymorphisms and cardiac risk assessment in vascular surgical patients. Anesthesiology. 2004; 101 (6): 1291–7. DOI: 10.1097/00000542-200412000-00008
  27. Donahue B.S. Factor V Leiden and perioperative risk. Anesth. Analg. 2004; 98 (6): 1623–34. DOI: 10.1213/01.ane.0000113545.03192.fd
  28. Donahue B.S., Gailani D., Higgins M.S., Drinkwater D.C., George A.L. Jr. Factor V Leiden protects against blood loss and transfusion after cardiac surgery. Circulation. 2003; 107 (7): 1003–8. DOI: 10.1161/01.cir.0000051864.28048.01
  29. Moor E., Silveira A., van't Hooft F., Tornvall P., Blombäck M., Wiman B. et al. Coagulation factor V (Arg506–>Gln) mutation and early saphenous vein graft occlusion after coronary artery bypass grafting. Thromb. Haemost. 1998; 80 (2): 220–4.
  30. McPherson R., Pertsemlidis A., Kavaslar N., Stewart A., Roberts R., Cox D.R. et al. A common allele on chromosome 9 associated with coronary heart disease. Science. 2007; 316 (5830): 1488–91. DOI: 10.1126/science.1142447
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Об авторах

  • Кокшенёва Инна Валериевна, доктор мед. наук, ст. науч. сотр.; ORCID
  • Закарая Ираклий Темурович, мл. науч. сотр.
  • Малороева Амина Исаевна, аспирант

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