Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Genetic risk factors of perioperative myocardial infarction. Part 2

Authors: Koksheneva I.V., Zakaraya I.T., Maloroeva A.I.

Company:
Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, 121552, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-6910-2021-18-2-109-117

UDC: 616.127-005.8:575

Link: Clinical Physiology of Blood Circulaiton. 2021; 2 (18): 97-108

Quote as: Koksheneva I.V., Zakaraya I.T., Maloroeva A.I. Genetic risk factors of perioperative myocardial infarction. Part 2. Clinical Physiology of Circulation. 2021; 18 (2): 109–17 (in Russ.). DOI: 10.24022/1814-6910-2021-18-2-109-117

Received / Accepted:  22.10.2020 / 11.11.2020

Full text:  

Abstract

Despite the improvement of surgical methods and protection of the myocardium, anesthesia, the development of perioperative myocardial infarction during cardiac surgery remains a common occurrence and is combined with a decrease in the immediate and distant survival. The pathophysiology of intraoperative myocardial infarction in cardiac surgery is based on three leading mechanisms: 1) systemic and local inflammation; 2) disorders in the blood coagulation system; 3) neuroendocrine stress. Genetic variability is present in each of these regulatory pathways. Genetic variants of different pathways may be present in the same patient, modulating the amount of myocardial injury. This review presents the published data on identified genetic variants associated with perioperative myocardial infarction in patients undergoing cardiac surgery. In the future, genetic studies can help in the preoperative prognostic assessment of the risk of myocardial infarction.

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****
  1. Mahaffey K.W., Roe M.T., Kilaru R., Alexander J.H., Van de Werf F., Califf R.M. et al. Creatine kinase-MB elevation after coronary artery bypass grafting surgery in patients with non-ST-segment elevation acute coronary syndromes predict worse outcomes: results from four large clinical trials. Eur. Heart. J. 2007; 28 (4): 425–32. DOI: 10.1093/eurheartj/ehl483
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  3. Ozaki K., Tanaka T. Genome-wide association study to identify SNPs conferring risk of myocardial infarction and their functional analyses. Cell. Mol. Life. Sci. 2005; 62 (16): 1804–13. DOI: 10.1007/s00018-005-5098-z
  4. Hirokawa M., Morita H., Tajima T., Takahashi A., Ashikawa K., Miya F. et al. A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese. Eur. J. Hum. Genet. 2015; 23 (3): 374–80. DOI: 10.1038/ejhg.2014.110
  5. Ozaki K., Tanaka T. Molecular genetics of coronary artery disease. J. Hum. Genet. 2016; 61 (1): 71–7. DOI: 10.1038/jhg.2015.70
  6. Podgoreanu M.V., Schwinn D.A. New paradigms in cardiovascular medicine: emerging technologies and practices: perioperative genomics. J. Am. Coll. Cardiol. 2005; 6; 46 (11): 1965–77. DOI: 10.1016/j.jacc. 2005.08.040
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  10. Collard C.D., Shernan S.K., Fox A.A., Bernig T., Chanock S.J., Vaughn W.K. et al. The MBL2 'LYQA secretor' haplotype is an independent predictor of postoperative myocardial infarction in whites undergoing coronary artery bypass graft surgery. Circulation. 2007; 116 (Suppl. 11): I106–12. DOI: 10.1161/CIRCULATIONAHA.106.679530
  11. Shaw A.D., Vaporciyan A.A., Wu X., King T.M., Spitz M.R., Putnam J.B., Dickey B.F. Inflammatory gene polymorphisms influence risk of postoperative morbidity after lung resection. Ann. Thorac. Surg. 2005; 79 (5): 1704–10. DOI: 10.1016/j.athoracsur.2004.10.010
  12. Brull D.J., Montgomery H.E., Sanders J., Dhamrait S., Luong L., Rumley A. et al. Interleukin-6 gene -174g>c and -572g>c promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery. Arterioscler. Thromb. Vasc. Biol. 2001; 21 (9): 1458–63. DOI: 10.1161/hq0901.094280
  13. Grocott H.P., Newman M.F., El-Moalem H., Bainbridge D., Butler A., Laskowitz D.T. Apolipoprotein E genotype differentially influences the proinflammatory and anti-inflammatory response to cardiopulmonary bypass. J. Thorac. Cardiovasc. Surg. 2001; 122 (3): 622–3. DOI: 10.1067/mtc.2001.115152
  14. Roth-Isigkeit A., Hasselbach L., Ocklitz E., Brückner S., Ros A., Gehring H. et al. Inter-individual differences in cytokine release in patients undergoing cardiac surgery with cardiopulmonary bypass. Clin. Exp. Immunol. 2001; 125 (1): 80–8. DOI: 10.1046/j.1365- 2249.2001.01521.x
  15. Lehmann L.E., Schroeder S., Hartmann W., Dewald O., Book M., Weber S.U. et al. A single nucleotide polymorphism of macrophage migration inhibitory factor is related to inflammatory response in coronary bypass surgery using cardiopulmonary bypass. Eur. J. Cardiothorac. Surg. 2006; 30 (1): 59–63. DOI: 10.1016/j.ejcts.2006.01.058
  16. Tomasdottir H., Hjartarson H., Ricksten A., Wasslavik C., Bengtsson A., Ricksten S.E. Tumor necrosis factor gene polymorphism is associated with enhanced systemic inflammatory response and increased cardiopulmonary morbidity after cardiac surgery. Anesth. Analg. 2003; 97 (4): 944–9. DOI: 10.1213/01.ane. 0000078574.76915.11
  17. Galley H.F., Lowe P.R., Carmichael R.L., Webster N.R. Genotype and interleukin-10 responses after cardiopulmonary bypass. Br. J. Anaesth. 2003; 91 (3): 424–6. DOI: 10.1093/bja/aeg174
  18. Kertai M.D., Li Y.J., Li Y.W., Ji Y., Alexander J., Newman M.F. et al.; Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team. Genome-wide association study of perioperative myocardial infarction after coronary artery bypass surgery. BMJ Open. 2015; 5 (5): e006920. DOI: 10.1136/bmjopen-2014-006920
  19. Rifón J., Páramo J.A., Panizo C., Montes R., Rocha E. The increase of plasminogen activator inhibitor activity is associated with graft occlusion in patients undergoing aorto-coronary bypass surgery. Br. J. Haematol. 1997; 99 (2): 262–7. DOI: 10.1046/j.1365-2141.1997.3913205.x
  20. Parolari A., Poggio P., Myasoedova V., Songia P., Bonalumi G., Pilozzi A. et al. Biomarkers in coronary artery bypass surgery: ready for prime time and outcome prediction? Front. Cardiovasc. Med. 2016; 2: 39. DOI: 10.3389/fcvm.2015.00039
  21. Girelli D., Russo C., Ferraresi P., Olivieri O., Pinotti M., Friso S. et al. Polymorphisms in the factor VII gene and the risk of myocardial infarction in patients with coronary artery disease. N. Engl. J. Med. 2000; 343 (11): 774–80. DOI: 10.1056/NEJM200009143431104
  22. Campo G., Valgimigli M., Ferraresi P., Malagutti P., Baroni M., Arcozzi C. et al. Tissue factor and coagulation factor VII levels during acute myocardial infarction: association with genotype and adverse events. Arterioscler. Thromb. Vasc. Biol. 2006; 26 (12): 2800–6. DOI: 10.1161/01.ATV.0000247249.82030.94
  23. Sakowicz A., Fendler W., Lelonek M., Gluba A., Pietrucha T. Two polymorphisms of the FVII gene and their impact on the risk of myocardial infarction in poles under 45 years of age. Mol. Biol. (Mosk). 2010; 44 (2): 229–34.
  24. Rinder Ch.S., Mathew J.P., Rinder H.M., Howe J.G., Fontes M., Crouch J. et al.; Multicenter Study of Perioperative Ischemia Research Group. Platelet PlA2 polymorphism and platelet activation are associated with increased troponin I release after cardiopulmonary bypass. Anesthesiology. 2002; 97 (5): 1118–22. DOI: 10.1097/00000542-200211000-00013
  25. Zotz R.B., Klein M., Dauben H.P., Moser C., Gams E., Scharf R.E. Prospective analysis after coronary-artery bypass grafting: platelet GP IIIa polymorphism (HPA1b/PIA2) is a risk factor for bypass occlusion, myocardial infarction, and death. Thromb. Haemost. 2000; 83 (3): 404–7.
  26. Faraday N., Martinez E.A., Scharpf R.B., KaschSemenza L., Dorman T., Pronovost P.J. et al. Platelet gene polymorphisms and cardiac risk assessment in vascular surgical patients. Anesthesiology. 2004; 101 (6): 1291–7. DOI: 10.1097/00000542-200412000-00008
  27. Donahue B.S. Factor V Leiden and perioperative risk. Anesth. Analg. 2004; 98 (6): 1623–34. DOI: 10.1213/01.ane.0000113545.03192.fd
  28. Donahue B.S., Gailani D., Higgins M.S., Drinkwater D.C., George A.L. Jr. Factor V Leiden protects against blood loss and transfusion after cardiac surgery. Circulation. 2003; 107 (7): 1003–8. DOI: 10.1161/01.cir.0000051864.28048.01
  29. Moor E., Silveira A., van't Hooft F., Tornvall P., Blombäck M., Wiman B. et al. Coagulation factor V (Arg506–>Gln) mutation and early saphenous vein graft occlusion after coronary artery bypass grafting. Thromb. Haemost. 1998; 80 (2): 220–4.
  30. McPherson R., Pertsemlidis A., Kavaslar N., Stewart A., Roberts R., Cox D.R. et al. A common allele on chromosome 9 associated with coronary heart disease. Science. 2007; 316 (5830): 1488–91. DOI: 10.1126/science.1142447
  31. Liu K.Y., Muehlschlegel J.D., Perry T.E., Fox A.A., Collard C.D., Body S.C., Shernan S.K.J. Common genetic variants on chromosome 9p21 predict perioperative myocardial injury after coronary artery bypass graft surgery. Thorac. Cardiovasc. Surg. 2010; 139 (2): 483–8. DOI: 10.1016/j.jtcvs.2009.06.032
  32. Liu Y., Sanoff H.K., Cho H., Burd Ch.E., Torrice C., Mohlke K.L. et al. INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis. PLoS. One. 2009; 4 (4): e5027. DOI: 10.1371/journal.pone.0005027
  33. Pasmant E., Laurendeau I., Háron D., Vidaud M., Vidaud D., Biéche I. Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF. Cancer. Res. 2007; 67 (8): 3963–9. DOI: 10.1158/0008-5472.CAN-06-2004
  34. Ye S., Willeit J., Kronenberg F., Xu Q., Kiechl S. Association of genetic variation on chro.mos.ome 9p21 with susceptibility and progression of atherosclerosis: a population-based, prospective study. J. Am. Coll. Cardiol. 2008; 52 (5): 378–84. DOI: 10.1016/j.jacc.2007.11.0
  35. Thompson A.R., Drenos F., Hafez H., Humphries S.E. Candidate gene association studies in abdominal aortic aneurysm disease: a review and meta-analysis. Eur. J. Vasc. Endovasc. Surg. 2008; 35 (1): 19–30. DOI: 10.1016/j.ejvs.2007.07.022
  36. Muehlschlegel J.D., Liu K.Y., Perry T.E., Fox A.A., Collard Ch.D., Shernan S.K., Body S., CABG Genomics Investigators. Chromosome 9p21 variant predicts mortality after coronary artery bypass graft surgery. Circulation. 2010; 122 (Suppl. 11): S60–5. DOI: 10.1161/CIRCULATIONAHA.109.924233
  37. Granger A., Abdullah I., Huebner F., Stout A., Wang T., Huebner T. et al. Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice. FASEB. J. 2008; 22 (10): 3549–60. DOI: 10.1096/fj.08-108548
  38. Kempf T., Eden M., Strelau J., Naguib M., Willenbockel C., Tongers J. et al. The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury. Circ. Res. 2006; 98 (3): 351–60. DOI: 10.1161/01.RES.0000202805.73038.48
  39. Zaugg M., Bestmann L., Wacker J., Lucchinetti E., Boltres A., Schulz C. et al. Adrenergic receptor genotype but not perioperative bisoprolol therapy may determine cardiovascular outcome in at-risk patients undergoing surgery with spinal block: the Swiss Beta Blocker in Spinal Anesthesia (BBSA) study: a double-blinded, placebo-controlled, multicenter trial with 1-year follow-up. Anesthesiology. 2007; 107 (1): 33–44. DOI: 10.1097/01.anes.0000267530.62344.a4
  40. Lasocki S., Iglarz M., Seince P.F., Vuillaumier-Barrot S., Vicaut E., Henrion D. et al. Involvement of renin-angiotensin system in pressure-flow relationship: role of angiotensin-converting enzyme gene polymorphism. Anesthesiology. 2002; 96 (2): 271–5. DOI: 10.1097/00000542-200202000-00008
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About Authors

  • Inna V. Koksheneva, Dr. Med. Sc., Senior Researcher; ORCID
  • Irakliy T. Zakaraya, Junior Researcher
  • Amina I. Maloroeva, Postgraduate

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