Научно-практический журнал
«Клиническая физиология кровообращения»

Главный редактор

Лео Антонович Бокерия, доктор медицинских наук, профессор, академик РАН и РАМН, директор ФГБУ «НМИЦССХ им. А.Н. Бакулева» МЗ РФ

Органопротекция севофлураном у кардиохирургических больных

Авторы: Г.В. Юдин

Организация:
ФГБУ «Национальный научно-практический центр сердечно-сосудистой хирургии им. А.Н. Бакулева» (директор – академик РАН и РАМН Л.А. Бокерия) Минздрава России, Рублевское ш., 135, Москва, 121552, Российская Федерация

Для корреспонденции: Сведения доступны для зарегистрированных пользователей.

Раздел: Обзоры

DOI: https://doi.org/10.24022/1814-6910-2017-14-3-125-130

УДК: 615.211:616.12-089

Библиографическая ссылка: Клиническая физиология кровообращения. 2017; 14 (3): 125-130

Цитировать как: Г.В. Юдин. Органопротекция севофлураном у кардиохирургических больных. Клиническая физиология кровообращения. 2017; 14 (3): 125-130. DOI: 10.24022/1814-6910-2017-14-3-125-130

Ключевые слова: севофлуран, органопротекция, тотальная внутривенная анестезия, сравнительный анализ, кардиохирургические больные

Поступила / Принята к печати:  Поступила 16.05.2017 Принята к печати 21.06.2017

Полнотекстовая версия:  

Аннотация

На сегодняшний день cевофлуран зарекомендовал себя как эффективный анестетик с минимальным количеством побочных эффектов, имеющий серьезный потенциал применения в кардиохирургии. В данном обзоре описаны его органопротективные свойства, в частности механизмы фармакологического прекондиционирования миокарда, антиапоптотические, противовоспалительные и антиоксидантные свойства. Представлены результаты экспериментальных работ, демонстрирующие возможности защиты севофлураном легочной ткани и сосудистого эндотелия при их повреждении. Приведены данные ряда клинических исследований и метаанализов о преимуществах анестезии севофлураном перед тотальной внутривенной анестезией у кардиохирургических больных. Изложена иная точка зрения о клинической эффективности органопротекции севофлураном.

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Об авторах

Юдин Геннадий Вячеславович, врач анестезиолог-реаниматолог; orcid.org/0000-0001-9976-6206

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