Clinical Physiology of Circulation
ISSN 1814-6910 (Print)
ISSN 2410-9134 (Online)
Chief Editor
Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery
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Organoprotection by sevoflurane in cardiosurgical patients
Authors:
Company:
Bakoulev National Scientific and Practical Center for Cardiovascular Surgery, Ministry of Health of the Russian Federation,
Rublevskoe shosse, 135, Moscow, 121552, Russian Federation
E-mail: Сведения доступны для зарегистрированных пользователей.
DOI:
UDC: 615.211:616.12-089
Link: Clinical Physiology of Blood Circulaiton. 2017; 14 (3): 125-130
Quote as: Yudin G.V. Оrganoprotection by sevoflurane in cardiosurgical patients. Klinicheskaya Fiziologiya Krovoobrashcheniya (Clinical Physiology of Circulation, Russian journal). 2017; 14 (3): 125–30 (in Russ.). DOI: 10.24022/1814- 6910-2017-14-3-125-130
Keywords:
sevoflurane
organoprotection; total intravenous anesthesia
comparative analysis
cardiosurgical patients
Received / Accepted: 16.05.2017/ 21.06.2017
Abstract
To date, sevoflurane has established itself as an effective anesthetic with minimal side effects, with significant potential application in cardiac surgery. This review describes its protective properties, in particular the mechanisms of pharmacological preconditioning of the myocardium, antiapoptotic, antioxidant and antiinflomatory effects. The results of experimental works demonstrate the possibility of protection by sevoflurane of lung tissue and vascular endothelium when they are damaged. The data of several clinical trials and meta-analyses about benefits of sevoflurane before total intravenous anesthesia in cardiosurgical patients are presented. A different view on the clinical efficacy of organ protection with sevoflurane is set out .References
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About Authors
Yudin Gennadiy Vyacheslavovich, Anesthesiologist-Intensivist; orcid.org/ 0000-0001-9976-6206If you found mistakes, select text and press Alt+A