Clinical Physiology of Circulation

ISSN 1814-6910 (Print)
ISSN 2410-9134 (Online)

 

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Issue's catalogue ➤ КФК. 2023; 20 (1): 1-88 ➤ Влияние аппарата механической поддержки кровообращения левожелудочкового обхода дискового типа на некоторые показатели крови

The effect of the left ventricular assist device of the disk type on some blood parameters

Authors: Golovina K.O., Golovin A.M., Ayzman R.I.

Company:
1 Novosibirsk State Pedagogical University, Novosibirsk, Russian Federation
2 IMPULSE-Project, Novosibirsk, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-6910-2023-20-1-78-88

UDC: 616.124.2-089.12

Link: Clinical Physiology of Blood Circulaiton. 2023; 1 (20): 78-88

Quote as: Golovina K.O., Golovin A.M., Ayzman R.I. The effect of the left ventricular assist device of the disk type on some blood parameters. Clinical Physiology of Circulation. 2023; 20 (1): 78–88 (in Russ.). DOI: 10.24022/1814-6910-2023-20-1-78-88

Keywords:  assist circulation disk pump hemolysis free hemoglobin plasma bench calves

Received / Accepted:  23.11.2022 / 14.03.2023

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Abstract

Objective. To investigate the effects on some blood parameters of a new type of mechanical assist pump with a low rotor speed.

Material and methods. An investigational study of a prototype of a left ventricular assist device of the disc type on some parameters donated human blood was performed using a bench simulating a systemic circulation (n = 6) and in an experiment on laboratory animals in vivo (n = 3). At the bench, the device operated at 2500 rpm with a performance of 5 ± 0.5 l/min. The black-and-white male calves were used in vivo tests for 7 days; the average age of the animals was 4 months, and the average weight was 90 kg. The pump was connected paracorporally by the scheme “left ventricular apex – descending thoracic artery”. The pump operation was started at a speed of 900 rpm in open chest conditions. Subsequently, the rotor speed was gradually increased until a performance of 5 ± 0.5 l/min was obtained. After stabilization of the pump operation mode and reaching adequate hemodynamic indices, a layered closure of the animal's chest was performed.

Results. According to the outcome of six bench tests, the average level of free haemoglobin (Free Hb) was 0.03 ±0.1g/l. The average value of the normalized index of hemolysis (NIH) in six tests was 0.0018; the average value of the modified hemolysis index (MIH) was 2.18. An increase in Free Hb in the range from 0.01 ± 0 g/l to 0.05 ± 0.1 g/l was detected in animal studies on the first and second day of the test. Later, from the third day to the end of the observation, fluctuations in Free Hb were in the range of 0.03–0.04 g/l and did not significantly differ from the baseline values. There was a significant decrease in hematocrit (Hct) during the same period (1–3 days), which by the 4th day was almost recovered to baseline values. During the test, the concentrations of sodium, calcium, chlorine ions, and blood pH practically did not change, and the concentration of potassium tended to increase by the 5th–7th day.

Conclusion. The mechanical circulatory support disc pump did not cause significant hemolytic, electrolyte, and acid-base imbalances in the blood during 240 min of operation on the bench (in vitro) and 7 days in the test in vivo. This fact makes it advisable to recommend the device for short-term replacement of the heart as a bridge” to organ transplantation or to relieve it.

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About Authors

  • Katerina O. Golovina, Postgraduate, Deputy General Director for Scientific Work; ORCID
  • Aleksandr M. Golovin, Cand. Tech. Sci., General Manager; ORCID
  • Roman I. Ayzman, Dr. Biol. Sci., Professor, Chief of Chair; ORCID

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