Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Formation of cardiovascular disorders in Parkinson’s disease

Authors: Mamalyga M.L.

Company:
Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russian Federation

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DOI: https://doi.org/10.24022/1814-6910-2024-21-4-311-322

UDC: 616.1:616.858

Link: Clinical Physiology of Blood Circulaiton. 2024; 21 (4): 311-322

Quote as: Mamalyga M.L. Formation of cardiovascular disorders in Parkinson’s disease. Clinical Physiology of Circulation. 2024; 21 (4): 311–322 (in Russ.). DOI: 10.24022/1814-6910-2024-21-4-311-322

Received / Accepted:  26.11.2024 / 13.12.2024

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Abstract

The review analyzes clinical studies devoted to the study of pathogenetic mechanisms underlying the interdependence of processes in the brain and cardiovascular system in Parkinson’s disease (PD), which are currently largely unexplored. The work is aimed at informing practitioners about the prevalence of comorbid cardiocerebral dysfunctions in neurodegenerative injuries of the nigrostriatal system and the mechanisms of development that provoke them. The relevance of this problem is obvious in the development of new ways to treat PD, because when prescribing antiparkinsonian drugs, the doctor must be convinced that their use for many years, and often for the whole life, will not lead to cardiovascular disorders. Moreover, when developing a strategy for the treatment and prevention of cardiovascular disorders in PD and prescribing cardiotherapy, it should be taken into account that the risk of developing PD is mainly affected by elderly people, who not only increase the frequency of this neuropathology with age, but also a predisposition to cardiovascular diseases that can exacerbate neurological symptoms.

About Authors

Maksim L. Mamalyga, Dr. Med. Sci., Leading Researcher; ORCID

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