Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Key pathways of diabetes-associated cardiovascular disorders: molecular mechanisms, prognostic factors of survival

Authors: Mamalyga M.L.

DOI: https://doi.org/10.24022/1814-6910-2025-22-2-119-133

UDC: 616.12:616.379-008.64

Link: Clinical Physiology of Blood Circulaiton. 2025; 22 (2): 119-133

Quote as: Mamalyga M.L. Key pathways of diabetes-associated cardiovascular disorders: molecular mechanisms, prognostic factors of survival. Clinical Physiology of Circulation. 2025; 22 (2): 119–133 (in Russ.). DOI: 10.24022/1814- 6910-2025-22-2-119-133

Received / Accepted:  19.05.2025 / 30.05.2025

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Abstract

The aim of the study is a comprehensive analysis of modern concepts of the key molecular and cellular mechanisms of cardiovascular disorders in diabetes mellitus, and to clarify their role in the formation of clinical phenotypes of complications and individual survival.

The review analyzes the results of modern fundamental and clinical studies devoted to the study of pathogenetic mechanisms underlying risk factors and clinical consequences of cardiovascular disorders in patients with diabetes mellitus, as well as the study of the interdependence of diabetes-associated cardiovascular complications and their long-

term consequences. The work is aimed at informing practitioners about the features of key molecular, metabolic and pathophysiological processes of cardiovascular disorders in diabetes mellitus, assessing epidemiological and clinical risks, as well as describing long-term consequences, such as atherosclerosis, coronary heart disease, myocardial infarction and heart failure. Special attention is paid to an interdisciplinary approach that allows doctors and researchers to optimize strategies for early diagnosis, personalized prevention and therapy, reducing mortality and improving the quality of life of patients. In addition, the article focuses on poorly understood aspects of the problem and offers directions for further research, in particular, it concerns the role of new biomarkers, genetic factors and innovative therapeutic targets that meet the requirements of evidence-based medicine.


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