Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Genetic aspects of cardiotoxicity: from mechanisms to personalized medicine

Authors: Buziashvili Yu.I., Matskeplishvili S.T., Asymbekova E.U., Tugeeva E.F., Akildzhonov F.R.

DOI: https://doi.org/10.24022/1814-6910-2025-22-3-203-211

UDC: 616.12-009.3:612.314.2

Link: Clinical Physiology of Blood Circulaiton. 2025; 22 (3): 203-212

Quote as: Buziashvili Yu.I., Matskeplishvili S.T., Asymbekova E.U., Tugeeva E.F., Akildzhonov F.R. Genetic aspects of cardiotoxicity: from mechanisms to personalized medicine. Clinical Physiology of Circulation. 2025; 22 (3): 203–211 (in Russ.). DOI: 10.24022/1814-6910-2025-22-3-203-211

Received / Accepted:  04.08.2025 / 25.08.2025

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Abstract

The development of effective anticancer therapies over the past three decades has contributed to a decrease in cancer mortality. Despite existing clinical guidelines, identifying high-risk patients remains challenging. Genetic screening based on a patient’s genotype offers a more accurate method for assessing the risk of cardiotoxicity. Genetic variations can help identify patients with an increased likelihood of developing cardiotoxicity, opening up new opportunities to understand its mechanisms and develop personalized approaches to treatment and prevention. However, further research aimed at refining genetic markers, developing risk stratification algorithms, and improving patient monitoring methods is needed to implement such methods in clinical practice.

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