Clinical Physiology of Circulation

ISSN 1814-6910 (Print)
ISSN 2410-9134 (Online)

 

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Issue's catalogue ➤ КФК. 2025; 22 (4): 287-382 ➤ Влияние изменения характеристик напряжения сдвига на активность транскрипционных факторов при развитии дисфункции эндотелиальных клеток

The effect of changes in shear stress characteristics on the activity of transcription factors in the development of endothelial cell dysfunction

Authors: Sannikov A.B.1, Tsygan V.N.2, Bolevich S.B.3

Company:
1 Privolzsky Research Medical University, Vladimir, Russian Federation
2 Kirov St. Petersburg Military Medical Academy, St. Petersburg, Russian Federation
3 Sechenov First Moscow Medical University, Moscow, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-6910-2025-22-4-305-319

UDC: 616.13-004.6:611.018.74

Link: Clinical Physiology of Blood Circulaiton. 2025; 22 (4): 305-319

Quote as: Sannikov A.B., Tsygan V.N., Bolevich S.B. The effect of changes in shear stress characteristics on the activity of transcription factors in the development of endothelial cell dysfunction. Clinical Physiology of Circulation. 2025; 22 (4): 305–319 (in Russ.). DOI: 10.24022/1814-6910-2025-22-4-305-319

Keywords:  vascular wall endothelial cell shear stress mechanotransduction intracellular signaling signaling pathways transcription factors

Received / Accepted:  14.10.2025 / 29.10.2025

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Abstract

Currently, the Shear Stress (SS) concept of endothelial cells (ECs) is the main physiological factor in maintaining their functional activity. The involvement of numerous sensory membrane protein molecules in the mechanotransduction process is closely related to the activation of intracellular signaling pathways, the end point of which is the control of transcription factors that have feedback with numerous intracellular regulators of redox processes and enzyme activity, among which one of the key roles belongs to nitric oxide synthase (eNOS). According to modern data, dynamic changes in blood flow entail a change in the characteristics of shear stress, which changes from laminar (LSS) and pulse (PSS) to turbulent (TSS), low (LowSS) and oscillatory (OSS). In this regard, attempts are currently being made to establish the relationship and influence of changes in shear stress characteristics on the activity of the main transcription factors (Kruppel-like factor – KLF2, nuclear factor Kappa B – NF–kB, redox-sensitive factor – Nrf2), which can have a significant impact on the formation of the pro-inflammatory phenotype of endothelial cells with their subsequent development. dysfunctions. An in-depth understanding of these processes will significantly change our view of the pathophysiological and molecular mechanisms of the development of cardiovascular pathologies in general.

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About Authors

  • Aleksandr B. Sannikov, Cand. Med. Sci., Сardiovascular Surgeon, Associate Professor; ORCID
  • Vasiliy N. Tsygan, Dr. Med. Sci., Professor, Academician of the Russian Academy of Natural Sciences, Medical Sciences, Head of the Chair; ORCID
  • Sergey B. Bolevich, Dr. Med. Sci., Professor, Head of the Chair; ORCID

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