Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Influence of biomarkers of arterial stiffness and inflammation on the risk of multifocal atherosclerosis

Authors: Buziashvili Yu.I.1, Koksheneva I.V.1, Matskeplishvili S.T.2, Timerbulatova T.R.1, Ambatiello S.G.1, Alpenidze V.A.1, Buziashvili V.Yu.1, Ibragimov M.S.1

Company:
1 Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russian Federation
2 University Clinic of the Medical Scientific and Educational Institute of Lomonosov Moscow State University, Moscow, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/ 1814-6910-2025-22-4-329-345

UDC: 616.13-004.6

Link: Clinical Physiology of Blood Circulaiton. 2025; 22 (4): 329-345

Quote as: Buziashvili Yu.I., Koksheneva I.V., Matskeplishvili S.T., Timerbulatova T.R., Ambatiello S.G., Alpenidze V.A., Buziashvili V.Yu., Ibragimov M.S. Influence of biomarkers of arterial stiffness and inflammation on the risk of multifocal atherosclerosis. Clinical Physiology of Сirculation. 2025; 22 (4): 329–345 (in Russ.). DOI: 10.24022/1814-6910-2025-22-4-329-345

Received / Accepted:  16.10.2025 / 01.12.2025

Download
Full text:  

Abstract

Objective. To evaluate the relationship between markers of endothelial function, arterial stiffness, and humoral markers of inflammation with the risk of developing multifocal atherosclerosis.

Material and methods. The study included 80 patients: 50 with multifocal atherosclerosis (MA) and 30 with isolated coronary artery disease. Arterial stiffness parameters, endothelial function, plasma levels of inflammatory markers (CRP, sE-selectin, sP-selectin, IL-6, sVCAM, fibrinogen), calculated indices of systemic inflammation (SIRI, SII, AISI), and lipid profile parameters were assessed.

Results. Markers involved in the regulation of pathways associated with endothelial function, arterial stiffness, inflammation, and lipid metabolism play a significant role in the pathogenesis of multifocal atherosclerosis. The constructed logistic prognostic model for the risk of multifocal atherosclerosis revealed that the most influential factors were: duration of coronary artery disease, endothelium-dependent vasodilation after NTG, vascular strain, distensibility, compliance, stiffness index, and elastic/pressure/strain modulus.

Conclusion. Markers of arterial stiffness, endothelial function, and inflammation (sP-selectin) may be useful additional tools in assessing cardiovascular risk in clinical practice and can be used to develop risk scores for multifocal atherosclerosis and possible future cardiovascular events.

About Authors

  • Yuri I. Buziashvili, Dr. Med. Sci., Professor, Academician of the Russian Academy of Sciences, Head of the Clinical Diagnostic Department; ORCID
  • Inna V. Koksheneva, Dr. Med. Sci., Professor, Senior Researcher, Associate Professor of the Clinical and Diagnostic Department; ORCID
  • Simon T. Matskeplishvili, Dr. Med. Sci., Professor, Academician of the Russian Academy of Sciences, Deputy Director for Scientific Work of the Medical Research and Educational Center of Lomonosov Moscow State University; ORCID
  • Tabarik R. Timerbulatova, Resident of the Clinical Diagnostic Department; ORCID
  • Sergey G. Ambatiello, Dr. Med. Sci., Leading Researcher, Associate Professor of the Clinical and Diagnostic Department; ORCID
  • Victoriya A. Alpenidze, Cand. Med. Sci., Ultrasound Diagnostics Doctor at the Clinical Diagnostic Department
  • Victoriya Yu. Buziashvili, Cand. Med. Sci., Junior Researcher, Associate Professor of the Clinical and Diagnostic Department; ORCID
  • Murat S. Ibragimov, Cand. Med. Sci., Cardiologist of the Clinical and Diagnostic Department; ORCID

 If you found mistakes, select text and press Alt+A