Clinical Physiology of Circulation

ISSN 1814-6910 (Print)
ISSN 2410-9134 (Online)

 

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Issue's catalogue ➤ КФК. 2025; 22 (4): 287-382 ➤ Влияние биомаркеров артериальной жесткости и воспаления на риск мультифокального атеросклероза

Influence of biomarkers of arterial stiffness and inflammation on the risk of multifocal atherosclerosis

Authors: Buziashvili Yu.I.1, Koksheneva I.V.1, Matskeplishvili S.T.2, Timerbulatova T.R.1, Ambatiello S.G.1, Alpenidze V.A.1, Buziashvili V.Yu.1, Ibragimov M.S.1

Company:
1 Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russian Federation
2 University Clinic of the Medical Scientific and Educational Institute of Lomonosov Moscow State University, Moscow, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/ 1814-6910-2025-22-4-329-345

UDC: 616.13-004.6

Link: Clinical Physiology of Blood Circulaiton. 2025; 22 (4): 329-345

Quote as: Buziashvili Yu.I., Koksheneva I.V., Matskeplishvili S.T., Timerbulatova T.R., Ambatiello S.G., Alpenidze V.A., Buziashvili V.Yu., Ibragimov M.S. Influence of biomarkers of arterial stiffness and inflammation on the risk of multifocal atherosclerosis. Clinical Physiology of Сirculation. 2025; 22 (4): 329–345 (in Russ.). DOI: 10.24022/1814-6910-2025-22-4-329-345

Keywords:  multifocal atherosclerosis; arterial stiffness endothelial dysfunction inflammation

Received / Accepted:  16.10.2025 / 01.12.2025

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Abstract

Objective. To evaluate the relationship between markers of endothelial function, arterial stiffness, and humoral markers of inflammation with the risk of developing multifocal atherosclerosis.

Material and methods. The study included 80 patients: 50 with multifocal atherosclerosis (MA) and 30 with isolated coronary artery disease. Arterial stiffness parameters, endothelial function, plasma levels of inflammatory markers (CRP, sE-selectin, sP-selectin, IL-6, sVCAM, fibrinogen), calculated indices of systemic inflammation (SIRI, SII, AISI), and lipid profile parameters were assessed.

Results. Markers involved in the regulation of pathways associated with endothelial function, arterial stiffness, inflammation, and lipid metabolism play a significant role in the pathogenesis of multifocal atherosclerosis. The constructed logistic prognostic model for the risk of multifocal atherosclerosis revealed that the most influential factors were: duration of coronary artery disease, endothelium-dependent vasodilation after NTG, vascular strain, distensibility, compliance, stiffness index, and elastic/pressure/strain modulus.

Conclusion. Markers of arterial stiffness, endothelial function, and inflammation (sP-selectin) may be useful additional tools in assessing cardiovascular risk in clinical practice and can be used to develop risk scores for multifocal atherosclerosis and possible future cardiovascular events.

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****
  1. Buziashvili Yu.I., Koksheneva I.V., Golubev E.P. et al. Use of humoral inflammation biomarkers in predicting coronary artery bypass graft dysfunction. Creative Cardiology. 2024; 18 (3): 350–361 (in Russ.). DOI: 10.24022/1997-3187-2024-18-3-350-361
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  4. Singh T.P., Morris D.R., Smith S. et al. systematic review and meta-analysis of the association between c-reactive protein and major cardiovascular events in patients with peripheral artery disease. Eur. J. Vasc. Endovasc. Surg. 2017; 54 (2): 220–233. DOI: 10.1016/j. ejvs.2017.05.009
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  7. Skoglund P.H., Arpegård J., Ostergren J. et al. Amino-terminal pro-B-type natriuretic peptide and high-sensitivity C-reactive protein but not cystatin C predict cardiovascular events in male patients with peripheral artery disease independently of ambulatory pulse pressure. Am. J. Hypertens. 2014; 27 (3): 363–371. DOI: 10.1093/ajh/hpt278
  8. Kremers B., Wübbeke L., Mees B. et al. Plasma biomarkers to predict cardiovascular outcome in patients with peripheral artery disease: a systematic review and meta-analysis. Arterioscler. Thromb. Vasc. Biol. 2020; 40 (9): 2018–2032. DOI: 10.1161/ATVBAHA.120.314774
  9. Zinellu A., Mangoni A.A. Systematic review and meta-analysis of the effect of statins on circulating E-Selectin, L-Selectin, and P-Selectin. Biomedicines. 2021; 9 (11): 1707. DOI: 10.3390/biomedicines9111707
  10. Af Geijerstam P., Rådholm K., Jonasson L. et al. P-selectin and C-reactive protein in relation to home blood pressure and coronary calcification: a SCAPIS substudy. J. Hypertens. 2024; 42 (7): 1226–1234. DOI: 10.1097/HJH.0000000000003718
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  13. Buziashvili Yu.I., Koksheneva I.V., Timerbulatova T.R. et al. Indicators of endothelial dysfunction and arterial stiffness as markers of multifocal atherosclerosis. The Bulletin of Bakoulev Center. Cardiovascular Diseases. 2025; 26 (2): 118–130 (in Russ.). DOI: 10.24022/1810-0694-2025-26-2-118-130
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  15. Zhou M., Yu Y., Chen R. et al. Wall shear stress and its role in atherosclerosis. Front. Cardiovasc. Med. 2023; 3 (10): 1083547. DOI: 10.3389/fcvm.2023.1083547
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  17. Golukhova E.Z., Pursanova D.M., Tkhashokova L.R. et al. Transthoracic ultrasound assessment of the biomechanics of the ascending aorta in aneurysm: comparison with histological data. The Bulletin of Bakoulev Center. Cardiovascular Diseases. 2025; 26 (1): 31–41 (in Russ.). DOI: 10.24022/1810-0694-2025-26-1-31-41
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  20. Theofilis P., Sagris M., Oikonomou E. et al. inflamma-tory mechanisms contributing to endothelial dysfunction. Biomedicines. 2021; 9 (7): 781. DOI: 10.3390/biomedicines9070781
  21. Iraskhanov A.Sh., Buziashvili Yu.I., Koksheneva I.V. et al. The importance of inflammatory response mediators in the mechanisms of atherogenesis and their impact on the results of myocardial revascularization in patients with coronary heart disease. Creative Cardiology. 2023; 17 (3): 330–340 (in Russ.). DOI: 10.24022/1997-3187-2023-17-3-330-340
  22. Gluba-Brzózka A., Franczyk B., Rysz-Górzyńska M. et al. emerging anti-atherosclerotic therapies. Int. J. Mol. Sci. 2021; 22 (22): 12109. DOI: 10.3390/ijms222212109
  23. Buziashvili Yu.I., Koksheneva I.V., Kamardinov D.Kh. et al. The influence of activation of the systemic inflammatory response on the risk of coronary conduit dysfunction and the incidence of cardiovascular complications after coronary artery bypass grafting. Russian Journal of Cardiology. 2025; 30 (4): 81–99 (in Russ.). DOI: 10.15829/1560-4071-2025-6112
  24. McEver R.P. Selectins: initiators of leucocyte adhesion and signalling at the vascular wall. Cardiovasc. Res. 2015; 107 (3): 331–339. DOI: 10.1093/cvr/cvv154
  25. Tscharre M., Vogel B., Tentzeris I. et al. Prognostic impact of soluble p-selectin on long-term adverse cardiovascular outcomes in patients undergoing percutaneous coronary intervention. Thromb. Haemost. 2019; 119 (2): 340–347. DOI: 10.1055/s-0038-1676563
  26. Zhang X., Zhang C., Ma Z. et al. Soluble P-selectin level in patients with cancer-associated venous and artery thromboembolism: a systematic review and meta-analysis. Arch. Med. Sci. 2023; 19 (1): 274–282. DOI: 10.5114/aoms/159039
  27. Kunutsor S.K., Bakker S.J.L., Dullaart R.P.F. Soluble vascular cell adhesion molecules may be protective of future cardiovascular disease risk: findings from the PREVEND Prospective Cohort Study. J. Atheroscler. Thromb. 2017; 24 (8): 804–818. DOI: 10.5551/jat.38836
  28. Kilic I.D., Findikoglu G., Alihanoglu Y.I. et al. Circulating adhesion molecules and arterial stiffness. Cardiovasc. J. Afr. 2015; 26 (1): 21–24. DOI: 10.5830/CVJA-2014-060
  29. de Faria A.P., Ritter A.M., Sabbatini A.R. et al. Deregulation of soluble adhesion molecules in resistant hypertension and its role in cardiovascular remodeling. Circ. J. 2016; 80 (5): 1196–1201. DOI: 10.1253/circj.CJ-16-0058
  30. Mozos I., Malainer C., Horbańczuk J. et al. inflammatory markers for arterial stiffness in cardiovascular diseases. Front. Immunol. 2017; 8: 1058. DOI: 10.3389/fimmu. 2017.01058
  31. Mäki-Petäjä K.M., Elkhawad M., Cheriyan J. et al. Anti-tumor necrosis factor-alpha therapy reduces aortic inflammation and stiffness in patients with rheumatoid arthritis. Circulation. 2012; 126 (21): 2473–2480. DOI: 10.1161/CIRCULATIONAHA.112.120410
  32. Upala S., Wirunsawanya K., Jaruvongvanich V. et al. Effects of statin therapy on arterial stiffness: a systematic review and meta-analysis of randomized controlled trial. Int. J. Cardiol. 2017; 227: 338–341. DOI: 10.1016/j.ijcard.2016.11.073
  33. Angoff R., Mosarla R.C., Tsao C.W. aortic stiffness: epidemiology, risk factors, and relevant biomarkers. Front. Cardiovasc. Med. 2021; 8: 709396. DOI: 10.3389/fcvm.2021.709396

About Authors

  • Yuri I. Buziashvili, Dr. Med. Sci., Professor, Academician of the Russian Academy of Sciences, Head of the Clinical Diagnostic Department; ORCID
  • Inna V. Koksheneva, Dr. Med. Sci., Professor, Senior Researcher, Associate Professor of the Clinical and Diagnostic Department; ORCID
  • Simon T. Matskeplishvili, Dr. Med. Sci., Professor, Academician of the Russian Academy of Sciences, Deputy Director for Scientific Work of the Medical Research and Educational Center of Lomonosov Moscow State University; ORCID
  • Tabarik R. Timerbulatova, Resident of the Clinical Diagnostic Department; ORCID
  • Sergey G. Ambatiello, Dr. Med. Sci., Leading Researcher, Associate Professor of the Clinical and Diagnostic Department; ORCID
  • Victoriya A. Alpenidze, Cand. Med. Sci., Ultrasound Diagnostics Doctor at the Clinical Diagnostic Department
  • Victoriya Yu. Buziashvili, Cand. Med. Sci., Junior Researcher, Associate Professor of the Clinical and Diagnostic Department; ORCID
  • Murat S. Ibragimov, Cand. Med. Sci., Cardiologist of the Clinical and Diagnostic Department; ORCID

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