Clinical Physiology of Circulation

ISSN 1814-6910 (Print)
ISSN 2410-9134 (Online)

 

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Issue's catalogue ➤ КФК. 2025; 22 (4): 287-382 ➤ Результаты гибридных вмешательств при лечении пациентов с острой ишемией нижних конечностей

Outcomes of hybrid interventions in the treatment of patients with acute limb ischemia

Authors: Shchegolev A.A..1 2, Papoyan S.A..1 2.3 4, Asaturyan K.S.2, Gromov D.G..1 2, Markarov A.E.2, Shaginyan G.G.2 4, Amirkhanyan D.S.1 2, Syromyatnikov D.D..1

Company:
1 Pirogov Russian National Research Medical University, Moscow, Russian Federation
2Inozemtsev City Clinical Hospital of the Department of Health of the City of Moscow, Moscow, Russian Federation
3 Research Institute of Health Organization and Medical Management of the Department of Health of the City of Moscow, Moscow, Russian Federation
4 Russian Medical Academy of Continuing Professional Education, Moscow, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-6910-2025-22-4-359-365

UDC: 616.137-005.4-089.168

Link: Clinical Physiology of Blood Circulaiton. 2025; 22 (4): 359-365

Quote as: Shchegolev A.A., Papoyan S.A., Asaturyan K.S., Gromov D.G., Markarov A.E., Shaginyan G.G., Amirkhanyan D.S., Syromyatnikov D.D. Outcomes of hybrid interventions in the treatment of patients with acute limb ischemia. Clinical Physiology of Сirculation. 2025; 22 (4): 359–365 (in Russ.). DOI: 10.24022/1814-6910-2025-22-4-359-365

Keywords:  acute lower limb ischemia hybrid interventions endovascular treatment thrombolysis

Received / Accepted:  17.10.2025 / 06.11.2025

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Abstract

Relevance. Acute limb ischemia (ALI) results from an acute (<2 weeks), sharp decrease in arterial perfusion to a limb and can lead to limb loss and death. This condition is urgent and requires rapid revascularization using endovascular, surgical, and hybrid treatment methods.

Objectives. The aim of this study is to improve treatment outcomes for patients with acute lower limb ischemia. Material and methods. To address this objective, surgical treatment outcomes were analyzed in 184 patients with acute lower limb ischemia from 2016 to 2024. Patients were divided into two groups based on the type of revasculariza-tion procedure performed: group I – hybrid interventions; group II – isolated open interventions.

Results. Statistically significant differences were found in the incidence of thrombosis in the postoperative period during the 30-day follow-up. Hybrid procedures significantly reduce the risk of developing arterial thrombosis in the postoperative period (p = 0.004). The rate of limb amputation within 30 days was also lower in the hybrid group: 11 cases (9.7%) versus 12 cases (16.9%) in the open group. However, this difference was not statistically significant (p = 0.23), meaning the limb salvage rate was comparable in the two groups: 90.3% versus 83.1% in groups I and II, respectively.

Conclusion. The data from this study demonstrate that the results of hybrid surgical treatment for patients (group I) with acute lower extremity ischemia are significantly better than those of open procedures (group II).

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  4. Hess C.N., Rogers R.K., Wang T.Y., Fu R., Gundrum J., Allen LaPointe N.M., Hiatt W.R. Major adverse limb events and 1-year outcomes after peripheral artery revascularization. J. Am. Coll. Cardiol. 2018; 72 (9): 999–1011. DOI: 10.1016/j.jacc.2018.06.041
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About Authors

  • Aleksandr A. Schegolev, Dr. Med. Sci., Professor, Head of the Chair; ORCID
  • Simon A. Papoyan, Dr. Med. Sci., Professor, Head of the Department; ORCID
  • Karen S. Asaturyan, Cardiovascular Surgeon; ORCID
  • Dmitriy G. Gromov, Dr. Med. Sci., Head of the Department; ORCID
  • Arnold E. Markarov, Cand. Med. Sci., Chief Physician; ORCID
  • Gia G. Shahinyan, Dr. Med. Sci., Professor, Head of the Department, Neurosurgeon; ORCID
  • David S. Amirkhanyan, Cardiovascular Surgeon; ORCID
  • Daniil D. Syromyatnikov, Cand. Med. Sci., Cardiovascular Surgeon; ORCID

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