Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Changes in cerebral blood flow and its role in the formation of postoperative cerebral damage in patients after geometric reconstruction of the left ventricle

Authors: Lobacheva G.V., Maksimova A.G.

Company:
Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-6910-2026-23-1-28-36

UDC: 616.124.2-089.844:612.824-008

Link: Clinical Physiology of Blood Circulaiton. 2026; 23 (1): 28-36

Quote as: Lobacheva G.V., Maksimova A.G. Changes in cerebral blood flow and its role in the formation of postoperative cerebral damage in patients after geometric reconstruction of the left ventricle. Clinical Physiology of Сirculation. 2026; 23 (1): 28–36 (in Russ.). DOI: 10.24022/1814-6910-2026-23-1-28-36

Received / Accepted:  10.12.2025 / 10.03.2026

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Abstract

Objective. To evaluate the dynamics of cerebral blood flow in patients after geometric reconstruction of the left ventricle (LVGR) surgery and to determine the prognostic role of neuron-specific enolase (NSE) in the deterioration of cerebral hemodynamics.

Material and methods. The prospective study included 30 patients divided into 2 groups: 1st group – patients who underwent LVGR + сoronary artery bypass grafting (CABG), 2nd group – patients after CABG. Cerebral blood flow was assessed by transcranial doppler ultrasound. Quantitative determination of NSE concentration was chosen as an objective assessment of the functional state of the brain.

Results. Before surgery, patients of 1st group had lower Vpeak values for the middle cerebral artery (MCA) (p = 0.032) and the posterior cerebral artery (PCA) (p = 0.018), PI for the anterior cerebral artery (ACA) and RI for ACA were 19% and 31% higher, respectively (p = 0.032; p = 0.034). After surgery in 1st group, Vpeak for the ACA and PCA decreased by 17% and 47%, respectively (p = 0.043; p = 0.05), PI indicators for the ACA and PCA decreased by 25% and 19%, respectively (p = 0.023, p = 0.017), PI indicator for the MCA increased in patients of 1st and 2nd groups by 20% and 12%, respectively (p = 0.03; p = 0.045). Moderate positive correlations were found between the NSE indicators and Vpeak for both the ACA and PCA in 1st group of patients (r = 0.6 at p = 0.026, r = 0.73 at p = 0.02).

Conclusion. In patients with high functional class of chronic heart failure significant initial disturbances of cerebral hemodynamics were revealed. The leading role of perioperative hypoperfusion in the pathogenesis of early cerebral disorders in patients after left ventricular hypertrophy has been identified.


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