Clinical Physiology of Circulation

ISSN 1814-6910 (Print)
ISSN 2410-9134 (Online)

 

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Issue's catalogue ➤ КФК. 2019; 16 (3): 165-254 ➤ Опыт экспериментальных исследований аневризмы абдоминальной аорты

Experience of experimental studies of abdominal aortic aneurysm

Authors: T.R. Tibua, A.Yu. Gorodkov, V.S. Arakelyan

Company:
A.N. Bakoulev National Medical Research Center for Cardiovascular Surgery, Ministry of Health of the Russian Federation, Rublevskoe shosse, 135, Moscow, 121552, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-6910-2019-16-3-244-254

UDC: 616.136-007.64-092.4

Link: Clinical Physiology of Blood Circulaiton. 2019; 16 (3): 244-254

Quote as: Tibua T.R., Gorodkov A.Yu., Arakelyan V.S. Experience of experimental studies of abdominal aortic aneurysm. Clinical Physiology of Circulation. 2019; 16 (3): 244–54 (in Russ.). DOI: 10.24022/1814-6910-2019-16-3-244-254

Keywords:  abdominal aortic aneurysm experimental models laboratory animals

Received / Accepted:  18.07.2019/19.07.2019

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Abstract

The main complication of the abdominal aortic aneurysm (AAA) is its rupture, the pathophysiology of which has not been fully studied. In this case, the gap occurs with not only aneurysms of large, but also small size. So there was a need to study the pathophysiology of aneurysm, and since the 1960s began to develop experimental models of AAA in vivo. In 1960, S.G. Economou et al., for the first time created experimental models of aortic aneurysm in dogs, in 1961 G.A. Gresham, A.N. Howard, investigated the aortic rupture in turkeys [1, 2]. Throughout the history of cardiovascular surgery, many different experimental AAA models have been developed to further correct the disease in patients. Small animal models were used to understand the pathophysiology of the aortic aneurysm needed to develop new methods of conservative treatment. Models of large animals were used for the development of new methods of surgical treatment of AAA. The creation of artificial aortic aneurysms by damaging the vascular wall by various methods led to unpredictable growth rates and the risk of AAA rupture, the development of sacciform aneurysms or pseudoaneurysms. At the same time, morphological similarities between the areas of human and animal aneurysms make it possible to develop new reconstructive interventions on the aorta in the presence of aneurysm. The purpose of this article is a retrospective analysis of different types of experimental models of abdominal aortic aneurysm formation.

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About Authors

  • Teona R. Tibua, Postgraduate; orcid.org/0000-0002-9552-4856
  • Aleksandr Yu. Gorodkov, Dr. Biol. Sc., Head of Laboratory of Modeling and Study of the Pathology of Heart and Vessels with Operation Block and Vivarium; orcid.org/0000-0001-5597-4820
  • Valeriy S. Arakelyan, Dr. Med. Sc., Professor, Head of Arterial Pathology Surgery Department; orcid.org/0000-0002-0284-6793

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