Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Влияние липидных факторов риска ишемической болезни сердца на прогрессирование коронарной недостаточности у больных, подвергшихся операции коронарного шунтирования, в ранние и отдаленные (до 10 лет) сроки после вмешательства

Link: Clinical Physiology of Blood Circulaiton. 2007; (): -

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Abstract

It was the high level of low-density lipoprotein (LDL) cholesterol (>3,5 mmol/l), that delivered the most significant influence on the progress of coronary disease and end-points in ischemic heart disease patients after a coronary by-passing at stages of 10-year-long follow-up. It promoted augmentation of frequencies of myocardial infarction and ischemic stroke for 2,3 times (p <0,01). It was accompanied also by a high level of lethal outcomes (14,8%) and by significantly (p <0,05) smaller survival rate (on the average for 3,4 years shorter). Frequency of development of unfavorable cardiovascular events (not fatal myocardial infarction, ischemic stroke) for ischemic heart disease patients after coronary artery bypass surgery with raised level of triglycerides and with reduced level of high-density lypoprotein (LDL) cholesterol was increased more than twicely (p<0,001). The negative influence of a high level (more than 3,5 mmol/l) of low-density lipoprotein (LDL) cholesterol and of low ( 1,7 mmol/l) does influence negatively on these in 5 years after the coronary surgery.

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