Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Концепция регуляции сердечно-сосудистой системы - от управления функциями к согласованию возможностей. часть 4. Анализ клинического материала

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Link: Clinical Physiology of Blood Circulaiton. 2013; (): -

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Abstract

Objective. To detect the role of regulation in genesis of dilated cardiomyopathy (DCM). The fourth part presents the clinical material and its analysis.
Material and methods. Data analysis of 49 patients with DCM was conducted. Computer monitoring, echocardiography, statistical and simulation analyses of function indexes and properties were used.
Results. All patients were divided into two groups. The first group included 23 patients with cardiac index (CI) above the average compared to all examined patients. The second group included 26 patients, CI was below the average. Mean cardiac indexes of group I and II differ on 48.5%. In group one indexes of pumping ability of the left and right ventricles are higher than 70 and 75% respectively than in group two with low CI. Correlation ratio of CI with indexes of pumping ability of the left and right ventricles is significant. Correlation coefficient was 0.63 and 0.61 respectively. Indexes of systolic and end-diastolic dimensions of left ventricle are increased in group I as well as in group II: 3.1, 3.7 and 3.0, 3.6 cm/m2 respectively. They do not differ in margin of errors of measurement. Mean cardiac index of patients of group I does not depend on final sizes of heart and group II depends on the fact: the more the volume the more CI. The relationship of CI with vascular resistance of systemic circulation is high for all examined patients as well as for groups: -0.76, -0.57, -0.91 respectively that is the more total peripheral vascular resistance the less CI. This dependence is more expressed for group II.
Conclusion. Severity of patients` state does not depend on decreased cardiac output. Treatment must be oriented on increase of CI not for normalization of functional state of left and/or right ventricle.

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