Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Cardiomyocyte nexuses and their abnormalities in myocardial pathology

Authors: T.V. Sukhacheva, I.F. Egorova

Company:
A.N. Bakoulev Scientific Center for Cardiovascular Surgery of Russian Academy of Medical Science

E-mail: Сведения доступны для зарегистрированных пользователей.

Link: Clinical Physiology of Blood Circulaiton. 2014; (): -

Quote as: Sukhacheva T.V., Egorova I.F. Cardiomyocyte nexuses and their abnormalities in myocardial pathology. Klinicheskaya Fiziologiya Krovoobrashcheniya. 2014; 1: 11-21.

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Abstract

Nexuses (gap junctions) ensure electrical coupling of cardiomyocytes and participate in heart rhythm maintenance. The review presents modern data on the structure and protein composition of the nexuses, their localization in cardiomyocytes, and their remodeling under conditions of myocardial pathology. The nexuses of ventricular cardiomyocytes undergo stereotypical changes in pathology, consisting in their partial redistribution from intercalated discs to lateral cell borders, that can be related to a decrease in connexin 43 content. At the same time, changes in atrial cardiomyocytes in myocardial pathology are diverse and can be accompanied by decrease or increase in the content of connexin 43 and, especially connexin 40. Published data suggest that protein composition, localization, and number of nexuses in cardiomyocytes depend on the tissue-specific patterns of these cells and change in conditions of myocardial pathology usually associated with heart rhythm disturbances.

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