Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


The approaches to nanomaterial biomedical safety evaluation

Authors: Sidorenko E.S., Fadeev A.A., Agafonov A.V.

Company:
A.N. Bakoulev Scientific Center for Cardiovascular Surgery of Russian Academy of Medical Sciences, Rublevskoe shosse, 135, Moscow, 121552, Russian Federation

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Link: Clinical Physiology of Blood Circulaiton. 2014; (): -

Quote as: Sidorenko E.S., Fadeev A.A., Agafonov A.V. The approaches to nanomaterial biomedical safety evaluation. Klinicheskaya Fiziologiya Krovoobrashcheniya. 2014; 2: 5–13.

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Abstract

The article provides a general view for safety evaluation of nanomaterials, which are beginning to be used as substrates of medicines for oral use, dermal exposure, inhalations, injections, and as the component of the materials for implantable medical devices.
The atoms or molecules on the surface of the nanomaterial may be chemically and biologically reactive, potentially con- tributing to the development of adverse effects when using in humans. Researchers manifest some concern over nanopar- ticles possible adverse effects. As new materials obtained on the basis of nanotechnologies, it is necessary to develop a system of methods by means of those one could assess the potential biological compatibility of new material, its toxicity, impact levels, and to get information that could be used for biomedical safety assessment of nanomaterials in long terms of its use as well.
The traditional approaches, standards and study protocols for biomedical assessment of chemical substances, including ultra fine particles, could be quite applicable for the determination of significant characteristics of nanomaterials. However, in the very near future the evaluation of nonmaterial will require an interdisciplinary approach for physicians, biologists, tox- icologists and specialists in materials science, chemistry, physics, biotechnology etc.

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