Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Aspects of mods pathogenesis in cardiac surgery patients

Authors: M .M . Rybka

Company:
A.N. Bakoulev Scientific Center for Cardiovascular Surgery, Ministry of Health of the Russia, Rublevskoe shosse, 135, Moscow, 121552, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

UDC: 616-083.98:616.12/14-089.168

Link: Clinical Physiology of Blood Circulaiton. 2016; 13 (2): 65-74

Quote as: Rybka M.M. Aspects of mods pathogenesis in cardiac surgery patients. Klinicheskaya Fiziologiya Krovoobrashcheniya (Clinical Physiology of Circulation, Russian journal). 2016; 13 (2): 65-74 (in Russ.)

Received / Accepted:  06.05.2016/11.05.2016

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Abstract

As is customary a literature on the pathogenesis of MODS focuses on the biochemical and cytological mechanisms of systemic inflammatory syndrome. This review focuses on the processes of ischemic and reperfusion damage of cells and tissues as the fundamental reason for the development of organ dysfunction and multiple organ failure. It is shown that microcirculation disorders are the cause of disorders of oxygen delivery to cells. At the same time the capillaries themselves undergo ischemia and reperfusion injury. Drastic changes in blood volume, minute flow rate typical of cardiac surgery are the factors leading to dysfunction of microcirculation, disturbance of oxygen delivery and the development of the IRI in cardiac surgical patients.

About Authors

Rybka Mikhail Mikhailovich, MD, PhD, Chief of Department of Anaesthesiology and Resuscitation

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