Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Acute liver failure etiology and pathogenesis

Authors: M.B. Yaroustovsky, M.V. Abramyan, E.V. Komardina

Company:
A.N. Bakoulev Scientific Center for Cardiovascular Surgery, Ministry of Health of the Russia, Rublevskoe shosse, 135, Moscow, 121552, Russian Federation

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UDC: 616.36-002.4-008.64

Link: Clinical Physiology of Blood Circulaiton. 2016; 13 (2): 75-84

Quote as: Yaroustovsky M.B., Abramyan M.V., Komardina E.V. Acute liver failure etiology and pathogenesis. Klinicheskaya Fiziologiya Krovoobrashcheniya (Clinical Physiology of Circulation, Russian journal). 2016; 13 (2): 75-84 (in Russ.).

Received / Accepted:  26.05.2016/29.05.2016

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Abstract

Acute liver failure usually develops in multiple organ dysfunction syndrome and carries a high mortality. This review represents recent data of acute liver failure etiology and pathogenesis: endogenous intoxication syndrome, hepatic encephalopathy, system inflammatory response, hepatorenal syndrome and hemostatic disorders were considered. There was also reviewed the conception of acute liver failure in sepsis and hypoxic hepatitis. Understanding of acute liver failure mechanisms allows to optimize the treatment approach.

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About Authors

Yaroustovsky Mikhail Borisovich, MD, PhD, DSc, Professor, Chief of Department of Gravitational Blood Surgery and Endoscopy; Abramyan Marina Vladimirovna, MD, PhD, Leading Research Associate; Komardina Ekaterina Viktorovna, MD, Junior Research Associate

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