Clinical Physiology of Circulation

ISSN 1814-6910 (Print)
ISSN 2410-9134 (Online)

 

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Issue's catalogue ➤ КФК. 2020; 17 (1): 5-69 ➤ Роль лучевой диагностики в оценке естественного старения головного мозга

Place of radiology in visualisation and estimation of brain aging changes

Authors: Yu.M. Portnov 1, S.E. Semenov 1, I.V. Sigitov 2, A.A. Korotkevich 1

Company:
1 Kuzbass Cardiology Center, Kemerovo, 650002, Russian Federation
2 L.S. Barbarash Kemerovo Regional Clinical Cardiology Dispensary, Kemerovo, 650002, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-6910-2020-17-1-5-12

UDC: 616-073.75+612.8

Link: Clinical Physiology of Blood Circulaiton. 2020; 17 (1): 5-12

Quote as: Portnov Yu.M., Semenov S.E., Sigitov I.V., Korotkevich A.A. Place of radiology in visualisation and estimation of brain aging changes. Clinical Physiology of Circulation. 2020; 17 (1): 5–12 (in Russ.). DOI: 10.24022/1814-6910-202017-1-5-12

Keywords:  brain volume brain shrinkage vascular risk factors

Received / Accepted:  21.11.2019/09.12.2019

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Abstract

Ability to visualise and quantify the changes in normal brain aging in vivo provides an opportunity to understand the underlying causes and location of this changes. In healthy adults, longitudinal changes in brain volume are not uniform. Although brain shrinkage is widespread, its magnitude varies across regions. The course of brain aging is predicated on multiple factors that are expressed to varying degrees in each individual. The brain shrinks with age evenly in reasonably healthy adults who showed no gross cognitive declines. The brain srankage is nonlinear and an individual's sex does not play a significant role in brain aging. Individual differences in the magnitude and variability of changes are significant and in certain critical regions are augmented by vascular risk factors.

References

  1. Трофимов А.В. Функциональная морфология старения. Успехи геронтологии. 2009; 22 (3): 401–8. [Trofimov A.V. Functional morphology of aging. Advances in Gerontology. 2009; 22 (3): 401–8 (in Russ.).]
  2. Грибанов А.В., Джос Ю.С., Дерябина И.Н., Депутат И.С., Емельянова Т.В. Старение головного мозга человека: морфофункциональные аспекты. Журнал неврологии и психиатрии им. С.С. Корсакова. 2017; 117 (1-2): 3–7. DOI: 10.17116/jnevro2017 117123-7 [Gribanov A.V., Dzhos Yu.S., Deryabina I.N., Deputat I.S., Yemelianova T.V. An aging brain: morphofunctional aspects. S.S. Korsakov Journal of Neurology and Psychiatry. 2017; 117 (1-2): 3–7 (in Russ.). DOI: 10.17116/jnevro2017117123-7]
  3. Гомазков О.А. Старение мозга и нейротрофическая терапия. М.: Икар; 2011. [Gomazkov O.A. Brain aging and neurotrophic therapy. Moscow: Ikar; 2011 (in Russ.).]
  4. Хавинсон В.Х., Анисимов В.Н. 35-летний опыт исследований пептидной регуляции старения. Успехи геронтологии. 2009; 22 (1): 11–23. [Khavinson V. Kh., Anisimov V.N. 35-year experience in study of peptide regulation of aging. Advances in Gerontology. 2009; 22 (1): 11–23 (in Russ.).]
  5. Худоерков Р.М., Сальков В.Н., Сальникова О.В., Соболев В.Б. Морфологические изменения нейронов и нейроглии в головном мозге быстро стареющих мышей линии SAMP1. Архив патологии. 2014; 76 (2): 22–5. [Khudoerkov R.M., Sal'kov V.N., Sal'nikova O.V., Sobolev V.B. Morphological changes of neurons and neuroglial cells in the brain of senescence-accelerated prone 1 (SAMP1) mice. Archive of Pathology. 2014; 76 (2): 22–5 (in Russ.).]
  6. Giedd J.N., Blumenthal J., Jeffries N.O., Castellanos F.X., Liu H., Zijdenbos A. et al. Brain development during childhood and adolescence: a longitudinal MRI study. Nat. Neurosci. 1999; 2 (10): 861–3. DOI: 10.1038/13158
  7. Крутько В.Н., Донцов В.И., Захарьящева О.В. Системная теория старения: методологические основы, главные положения и приложения. Авиакосмическая и экологическая медицина. 2009; 43 (1): 12–9. [Krut'ko V.N., Dontsov V.I., Zakhariashcheva O.V. The system theory of aging: methodological principles, basic tenets and applications. Aerospace and Environmental Medicine. 2009; 43 (1): 12–9 (in Russ.).]
  8. Ivanova D.G., Yankova T.M. The free radical theory of aging in search of a strategy for increasing life span. Folia Med. (Plovdiv). 2013; 55 (1): 33–41. DOI: 10.2478/folmed-2013-0003
  9. Калинченко С.Ю., Ворслов Л.О., Тюзиков И.А., Тишова Ю.А. Окислительный стресс как причина системного старения. Роль препаратов α-липоевой кислоты (эспа-липон) в лечении и профилактике возраст-ассоциированных заболеваний. Фарматека. 2014; 6 (279): 43–54. [Kalinchenko S.Yu., Vorslov L.O., Tyuzikov I.A., Tishova Yu.A. Oxidative stress as cause of systemic aging. Role of α-lipoic acid (espa-lipon) in the treatment and prevention of age-associated diseases. Farmateka. 2014; 6 (279): 43–54 (in Russ.).]
  10. Пальцев М.А., Кветной И.М., Полякова В.О., Кветная Т.В., Трофимов А.В. Нейроиммуноэндокринные механизмы старения. Успехи геронтологии. 2009; 22 (1): 24–36. [Paltsev M.A., Kvetnoy I.M., Polyakova V.O., Kvetnaia T.V., Trofimov A.V. Neuroimmunoendocrine mechanisms of aging. Advances in Gerontology. 2009; 22 (1): 24–36 (in Russ.).]
  11. Yamaura H., Ito M., Kubota K., Matsuzawa T. Brain atrophy during aging: a quantitative study with computed tomography. J. Gerontol. 1980; 35 (4): 492–8. DOI: 10.1093/geronj/35.4.492
  12. Портнов Ю.М., Семенов С.Е., Сырова И.Д., Сигитов И.В. Морфологические и перфузионные предикторы отдаленных церебральных нарушений у кардиохирургических пациентов. Сибирский медицинский журнал. 2019; 34 (1): 92–7. DOI: 10.29001/ 2073-8552-2018-34-1-92-97 [Portnov Yu.M., Semenov S.E., Syrova I.D., Sigitov I.V. Morphological and perfusion predictors of distant cerebral disorders in cardiac surgery patients. The Siberian Medical Journal. 2019; 34 (1): 92–7 (in Russ.). DOI: 10.29001/2073-8552-2018-34-1-92-97]
  13. Wahlund L.O., Almkvist O., Basun H., Julin P. MRI in successful aging, a 5-year follow-up study from the eighth to ninth decade of life. Magn. Reson. Imaging. 1996; 14 (6): 601–8. DOI: 10.1016/0730-725x(96)00098-7
  14. Гордеев Я.Я., Бойко Д.В., Шамова Т.М., Лебейко Т.Я. Физиологическое старение головного мозга по данным магнитно-резонансной томографии. Журнал Гродненского государственного медицинского университета. 2015; 2 (50): 60–2. [Gordeev Ya.Ya., Boyko D.V., Shamova T.M., LebeykoT.Ya. Physiological brain aging based on magnetic resonance imaging evidence. Journal of the Grodno State Medical University. 2015; 2 (50): 60–2 (in Russ.).]
  15. Sullivan E.V., Lim K.O., Mathalon D., Marsh L., Beal D.M., Harris D. et al. A profile of cortical gray matter volume deficits characteristic of schizophrenia. Cereb. Cortex. 1998; 8 (2): 117–24. DOI: 10.1093/ cercor/8.2.117
  16. Raz N., Lindenberger U., Rodrigue K.M., Kennedy K.M., Head D., Williamson A. et al. Regional brain changes in aging healthy adults: general trends, individual differences and modifiers. Cereb. Cortex. 2005; 15 (11): 1676–89. DOI: 10.1093/cercor/bhi044
  17. Jagust W.J., Budinger T.F., Reed B.R. The diagnosis of dementia with single photon emission computed tomography. Arch. Neurol. 1987; 44 (3): 258–62. DOI: 10.1001/archneur.1987.00520150014011
  18. Семенов С.Е., Милиневский Н.И., Короткевич А.А., Портнов Ю.М., Семенов А.С. Исследование перфузии при нарушениях церебрального кровообращения. Часть III (Бесконтрастные способы. Целесообразность и безопасность). Обзор. Комплексные проблемы сердечно-сосудистых заболеваний.2018; 7 (4): 101–11. DOI: 10.17802/2306-1278-2018-7-4-101-111 [Semenov S.E., Milinevskiy N.I., Korotkevich A.A., Portnov Yu.M., Semenov A.S. Cerebral perfusion and circulation disturbances. Part III (non-contrast methods, rationale and safety): a review. Complex Issues of Cardiovascular Diseases. 2018; 7 (4): 101–11 (in Russ.). DOI: 10.17802/2306-1278-2018-7-4-101-111]
  19. Валиханова А.М., Валиханов А.А., Хайдарова Г.Б. Магнитно-резонансная томография в диагностике атрофии головного мозга. Молодой ученый.2014; 19: 105–07. [Valikhanova A.M., Valikhanov A.A., Khaydarova G.B. Magnetic resonance imaging in the diagnosis of brain atrophy. Young Scientist. 2014; 19: 105–7 (in Russ.).]
  20. Pearlson G.D., Kim W.S., Kubos K.L., Moberg P.J., Jayaram G., Bascom M.J. et al. Ventricle-brain ratio, computed tomographic density, and brain area in 50 schizophrenics. Arch. Gen. Psychiatry. 1989; 46 (8): 690–7. DOI: 10.1001/archpsyc.1989.01810080020003
  21. Zatz L.M., Jernigan T.L., Ahumada J.A.J. White matter changes in cerebral computed tomography related to aging. J. Comput. Assist. Tomogr. 1982; 6 (1): 19–23. DOI: 10.1097/00004728-198202000-00002
  22. Корсунская Л.Л., Кузнецов В.В. Визуализация возрастных изменений головного мозга. Крымский терапевтический журнал. 2004; 1 (1): 42–8. [Korsunskaya L.L., Kuznetsov V.V. Visualization of age-related changes in the brain. Crimean Journal of Internal Diseases. 2004; 1 (1): 42–8 (in Russ.).]
  23. Сотникова В.В. Изменение морфометрических показателей моста у мужчин в разные возрастные периоды по данным компьютерной томографии. В кн.: Сборник статей научно-практической конференции, посвященной памяти доцента Д.Д. Смирнова «Весенние анатомические чтения». Гродно; 2017: 174–6. [Sotnikova V.V. Changes in morphometric parameters of the pons in men at different age periods according to computed tomography. In: Collection of articles of a scientific and practical conference dedicated to the memory of associate professor D.D. Smirnov “Spring anatomical readings”. Grodno; 2017: 174–6 (in Russ.).]
  24. Coffey C.E., Saxton J.A., Ratcliff G., Bryan R.N., Lucke J.F. Relation of education to brain size in normal aging implications for the reserve hypothesis. Neurology. 1999; 53 (1): 189–96. DOI: 10.1212/wnl.53.1.189
  25. Bartzokis G., Beckson M., Lu P.H., NuechterleinK.H., Edwards N., Mintz J. Age-related changes in frontal and temporal lobe volumes in men: a magnetic resonance imaging study. Arch. Gen. Psychiatry. 2001; 58 (5): 461–5. DOI: 10.1001/archpsyc.58.5.461
  26. Bartzokis G., Cummings J.L., Sultzer D., Henderson V.W., Nuechterlein K.H., Mintz J. White matter structural integrity in healthy aging adults and patients with Alzheimer disease: a magnetic resonance imaging study. Arch. Neurol. 2003; 60 (3): 393–8. DOI: 10.1001/archneur.60.3.393
  27. Tang S., Woodhall R.W., Shen Y.J., deBellard M.E., Saffell J.L., Doherty P. et al. Soluble myelin-associated glycoprotein (MAG) found in vivo inhibits axonal regeneration. Mol. Cell. Neurosci. 1997; 9 (5-6): 333–46. DOI: 10.1006/mcne.1997.0633
  28. Raz N. Aging of the brain and its impact on cognitive performance: integration of structural and functional findings. In: Craik F.I.M., Salthouse T.A. (Eds.). The handbook of aging and cognition. Mahwah: Lawrence Erlbaum Associates; 2000.
  29. Harding A.J., Halliday G.M., Kril J.J. Variation in hippocampal neuron number with age and brain volume. Cereb. Cortex. 1998; 8 (8): 710–8. DOI: 10.1093/ cercor/8.8.710
  30. Hodges J.R., Davies R.R., Xuereb J.H., Casey B., Broe M., Bak T.H. et al. Clinicopathological correlates in frontotemporal dementia. Ann. Neurol. 2004; 56 (3): 399–406. DOI: 10.1002/ana.20203
  31. Courchesne E., Chisum H.J., Townsend J., Cowles A., Covington J., Egaas B. et al. Normal brain development and aging: quantitative analysis at in vivo MR imaging in healthy volunteers. Radiology. 2000; 216 (3): 672–82. DOI: 10.1148/radiology.216.3.r00au37672
  32. Gosche K.M., Mortimer J.A., Smith C.D., Markesbery W.R., Snowdon D.A. et al. Hippocampal volume as an index of Alzheimer neuropathology: findings from the Nun Study. Neurology. 2002; 58 (10): 1476–82. DOI: 10.1212/wnl.58.10.1476
  33. Rettmann M.E., Kraut M.A., Prince J.L., ResnickS.M. Cross-sectional and longitudinal analyses of anatomical sulcal changes associated with aging. Cereb. Cortex. 2006; 16 (11): 1584–94. DOI: 10.1093/cercor/bhj095
  34. Good C.D., Johnsrude I., Ashburner J., Henson R.N., Friston K.J., Frackowiak R.S. Cerebral asymmetry and the effects of sex and handedness on brain structure: a voxel-based morphometric analysis of 465 normal adult human brains. Neuroimage. 2001; 14 (3): 685–700. DOI: 10.1006/nimg.2001.0857
  35. Cholfin J.A., Rubenstein J.L.R. Genetic regulation of prefrontal cortex development and function. Novartis Found Symp. 2007; 288: 165–73. DOI: 10.1002/ 9780470994030.ch12
  36. Tisserand D.J., van Boxtel M.P., Pruessner J.C., Hofman P., Evans A.C., Jolles J. A voxel-based morphometric study to determine individual differences in gray matter density associated with age and cognitive change over time. Cereb. Cortex. 2004; 14 (9): 966–73. DOI: 10.1093/cercor/bhh057
  37. Лукьянёнок П.И. Руководство для гипертоника: методическое пособие для профилактики осложнений артериальной гипертонии. Международный журнал экспериментального образования. 2010; 10: 22. [Luk'yanenok P.I. Guidelines for hypertension: a guide for the prevention of complications of hypertension. International Journal of Experimental Education. 2010; 10: 22 (in Russ.).]
  38. Birns J., Kalra L. Cognitive function and hypertension. J. Hum. Hypertens. 2009; 23 (2): 86–96. DOI: 10.1038/ jhh.2008.80
  39. Портнов Ю.М., Семенов С.Е., Лукьянёнок П.И. Влияние артериальной гипертонии на состояние тканевой перфузии головного мозга. Современные проблемы науки и образования. 2017; 4: 88. [Portnov Yu.M., Semenov S.E., Lukyanenok P.I. Influence of arterial hypertension on brain tissue perfusion condition. Modern Problems of Science and Education. 2017; 4: 88 (in Russ.).]
  40. Knox C.A. Effects of aging and chronic arterial hypertension on the cell populations in the neocortex and archicortex of the rat. Acta Neuropathol. 1982; 56 (2): 139–45. DOI: 10.1007/bf00690585
  41. Tzourio C., Laurent S., Debette S. Is hypertension associated with an accelerated aging of the brain? Hypertension. 2014; 63 (5): 894–903. DOI: 10.1161/ HYPERTENSIONAHA.113.00147
  42. Lanari A., Silvestrelli G., De Dominicis P., Tomassoni D., Amenta F., Parnetti L. Arterial hypertension and cognitive dysfunction in physiologic and pathologic aging of the brain. Am. J. Geriatr. Cardiol. 2007; 16 (3): 158–64. DOI: 10.1111/j.1076-7460.2007.06502

About Authors

  • Yuriy M. Portnov, Cand. Med. Sc., Junior Researcher, Radiologist; orcid.org/0000-0002-2882-1076
  • Stanislav E. Semenov, Dr. Med. Sc., Leading Researcher, Radiologist; orcid.org/0000-0002-1827-606X
  • Igor' V. Sigitov, Radiologist; orcid.org/0000-0003-3988-3261
  • Aleksey A. Korotkevich, Radiologist; orcid.org/0000-0002-2835-7779


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