Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Association of preload with hemoglobin level in patients with heart failure

Authors: A.A. Kupryashov, M.I. Rivnyak, N.N. Koloskova, L.A. Glushko, M.G. Plyushch, V.A. Mironenko, L.A. Bockeria

Company:
Bakoulev National Medical Research Center for Cardiovascular Surgery, Ministry of Health of the Russian Federation, Rublevskoe shosse, 135, Moscow, 121552, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-6910-2018-15-3-178-189

UDC: 616.12-008.46:616.155.16

Link: Clinical Physiology of Blood Circulaiton. 2018; 15 (3): 178-189

Quote as: Kupryashov A.A., Rivnyak M.I., Koloskova N.N., Glushko L.A., Plyushch M.G., Mironenko V.A., Bockeria L.A. Association of preload with hemoglobin level in patients with heart failure. Clinical Physiology of Circulation. 2018; 15 (3): 178–89 (in Russ.). DOI: 10.24022/1814-6910-2018-15-3-178-189

Received / Accepted:  09.07.2018/11.07.2018

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Abstract

Objective. To determine the reasons for the decline in the level of haematological parameters in patients with heart failure depending on the magnitude of the preload.

Material and methods. In a prospective observational study included 79 patients with chronic heart failure. Patients were divided into two groups depending on the magnitude of the initial preload, as the evaluation criterion which was considered in the concentration B-type natriuretic peptide (BNP).

Results. Patients with level BNP of less than 500 pg/ml baseline hemoglobin concentration was closely related to the number of erythrocytes, concentration of hemoglobin after surgery, need for perioperative transfusions and donor erythrocyte suspension, with the value of the peak oxygen consumption level and the time of reaching the anaerobic threshold, and ventilation equivalent for carbon dioxide. In the second group (BNP>500 pg/ml) noted a distinct correlation between the concentration of haemoglobin and peak oxygen consumption, but a decline in the value of the forecast of the number of erythrocytes, there was no correlation with postoperative hemoglobin concentration and volume of blood transfusions, the size of the anaerobic threshold. Lactate levels at 1 day after surgery in these patients was negatively associated with minimum postoperative hemoglobin levels and positively with the volume of blood transfusions.

Conclusion. The hemoglobin concentration should not be considered as a criterion for the diagnosis of heart-failure anemia, and may be used only for screening of this condition. Preoperative preparation of patients requires differential diagnosis of the causes of lower hemoglobin level and a deterministic pathogenetic therapy of this condition.

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About Authors

  • Kupryashov Aleksey Anatol'evich, Dr. Med. Sc., Head of Blood Transfusion Department; orcid.org/0000-0001-7673-4762
  • Rivnyak Marina Ivanovna, Postgraduate
  • Koloskova Nadezhda Nikolaevna, Cand. Med. Sc., Head of Department
  • Glushko Lyudmila Aleksandrovna, Cand. Med. Sc., Head of Department; orcid.org/0000-0002-3583-3366
  • Plyushch Marina Grigor'evna, Cand. Biol. Sc., Head of Biochemical Laboratory; orcid.org/0000-0002-0359-0195
  • Mironenko Vladimir Aleksandrovich, Dr. Med. Sc., Head of Department of Reconstructive Surgery and Aorta Root; orcid.org/0000-0003-1533-6212
  • Bockeria Leo Antonovich, Dr. Med. Sc., Professor, Academician of RAS and RAMS, Director; orcid.org/0000-0002-6180-2619

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