Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Pathogenesis of heparin-induced thrombocytopenia

Authors: Samsonova N.N., Esayan G.S., Rogal'skaya E.A., Yaroustovsky M.B.

Company:
Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, 121552, Russian Federation

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DOI: https://doi.org/10.24022/1814-6910-2020-17-4-294-298

UDC: 616.151.5:616.155.294

Link: Clinical Physiology of Blood Circulaiton. 2020; 4 (17): 294-298

Quote as: Samsonova N.N., Esayan G.S., Rogal'skaya E.A., Yaroustovsky M.B. Pathogenesis of heparin-induced thrombocytopenia. Clinical Physiology of Circulation. 2020; 17 (4): 294–8 (in Russ.). DOI: 10.24022/1814-6910-2020-17-4-294-298

Received / Accepted:  18.06.2020 / 26.06.2020

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Abstract

Heparin induced thrombocytopenia (HIT) is a serious complication in cardiac surgery with heparin use. The clinical manifestation of HIT is thrombosis in the presence of thrombocytopenia. At the heart of the pathogenesis of HIT is the formation of antibodies to the complex of platelet factor 4 (PF-4) and heparin, which, interacting with FcyRIIA receptors of cells, induce increased expression of the tissue factor and intense thrombin formation. The thrombotic risk during HIT persists from several days to weeks. The immune response to PF-4–heparin is more common than the clinical manifestations of thrombocytopenia or thrombosis. Infectious/inflammatory complications are predisposing states for the development of HIT. This review summarizes current understanding about the antigen, antibodies of HIT and mechanisms of thrombus formation.

About Authors

  • Natal'ya N. Samsonova, Dr. Med. Sc., Professor, Chief Researcher; ORCID
  • Galina S. Esayan, Junior Researcher; ORCID
  • Ekaterina A. Rogal'skaya, Cand. Med. Sc., Head of Clinical Laboratory Diagnostics Division; ORCID
  • Mikhail B. Yaroustovsky, Dr. Med. Sc., Professor, Corresponding Member of RAS, Head of Department of Gravitational Blood Surgery and Endoscopy, Deputy Director of the Burakovsky Institute of Cardiac Surgery; ORCID

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