Clinical Physiology of Circulation

ISSN 1814-6910 (Print)
ISSN 2410-9134 (Online)

 

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Issue's catalogue ➤ КФК. 2021; 18 (2): 93-180 ➤ Сепсис и септический шок в сердечно-сосудистой хирургии: современные методы диагностики и лечения

Sepsis and septic shock in cardiovascular surgery: modern methods of diagnostics and treatment

Authors: Bockeria L.A., Gasymov E.G., Abdulgasanov R.A., Abdulgasanova M.R.

Company:
Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, 121552, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-6910-2021-18-2-97-108

UDC: 616.12-089: 616.94

Link: Clinical Physiology of Blood Circulaiton. 2021; 2 (18): 97-108

Quote as: Bockeria L.A., Gasymov E.G., Abdulgasanov R.A., Abdulgasanova M.R. Sepsis and septic shock in cardiovascular surgery: modern methods of diagnostics and treatment. Clinical Physiology of Circulation. 2021; 18 (2): 97–108 (in Russ.). DOI: 10.24022/1814-6910-2021-18-2-97-108

Keywords:  sepsis septic shock infusion therapy antibiotic therapy surgical treatmeant

Received / Accepted:  18.01.2021 / 02.02.2021

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Abstract

Despite the improvement of surgical methods and protection of the myocardium, anesthesia, the development of perioperative myocardial infarction during cardiac surgery remains a common occurrence and is combined with a decrease in the immediate and distant survival. The pathophysiology of intraoperative myocardial infarction in cardiac surgery is based on three leading mechanisms: 1) systemic and local inflammation; 2) disorders in the blood coagulation system; 3) neuroendocrine stress. Genetic variability is present in each of these regulatory pathways. Genetic variants of different pathways may be present in the same patient, modulating the amount of myocardial injury. This review presents the published data on identified genetic variants associated with perioperative myocardial infarction in patients undergoing cardiac surgery. In the future, genetic studies can help in the preoperative prognostic assessment of the risk of myocardial infarction.

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****
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  11. Levy M.M., Rhodes A., Phillips G.S., Townsend S.R., Schorr C.A., Beale R. et al. Surviving sepsis campaign: association between performance metrics and outcomes in a 7.5-year study. Crit. Care Med. 2015; 43 (1): 3–12. DOI: 10.1097/CCM.0000000000000723
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  14. Vincent J.L., Moreno R., Takala J., Willatts S., De Mendonca A., Bruining H. et al. The SOFA (Sepsisrelated Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intens. Care Med. 1996; 22 (7): 707–10. PMID: 8844239. DOI: 10.1007/bf01709751
  15. Fernando S.M., Tran A., Taljaard M., Cheng W., Rochwerg B., Seely A.J.E. et al. Systemic inflamatory response syndrome, quick sequential organ function assessment, and organ dysfunction: insights from a prospective database of ED patients with infection. Ann. Intern. Med. 2018; 168 (4): 266–75. DOI: 10.7326/M17-2820
  16. Gül F., Arslantas M.K., Cinel I., Kumar A. Changing definitions of sepsis. Turk. J. Anaesthesiol. Reanim. 2017; 45 (3): 129–38. DOI: 10.5152/TJAR.2017.93753
  17. Seymour C.W., Liu V.X., Iwashyna T.J., Brunkhorst F.M., Rea T.D., Scherag A. et al. Assessment of clinical criteria for sepsis: for the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016; 315 (8): 762–74. DOI: 10.1001/jama. 2016.0288
  18. Williams J.M., Greenslade J.H., McKenzie J.V., Chu K., Brown A.F.T., Lipman J. Systemic inflammatory response syndrome, quick sequential organ function assessment, and organ dysfunction: insights from a prospective database of ED patients with infection. Chest. 2017; 151 (3): 586–96. DOI: 10.1016/j.chest. 2016.10.057
  19. Kumar A., Ellis P., Arabi Y., Roberts D., Light B., Parillo J.E. et al.; Cooperative Antimicrobial Therapy of Septic Shock Database Research Group. Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock. Chest. 2009; 136 (5): 1237–48. DOI: 10.1378/chest.09-0087
  20. Kumar A., Roberts D., Wood K.E., Light B., Parillo J.E., Sharma S. et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit. Care Med. 2006; 34 (6): 1589–96. DOI: 10.1097/01.CCM.0000217961.75225.E9
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About Authors

  • Inna V. Koksheneva, Dr. Med. Sc., Senior Researcher; ORCID
  • Irakliy T. Zakaraya, Junior Researcher
  • Amina I. Maloroeva, Postgraduate

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