Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Sepsis and septic shock in cardiovascular surgery: modern methods of diagnostics and treatment

Authors: Bockeria L.A., Gasymov E.G., Abdulgasanov R.A., Abdulgasanova M.R.

Company:
Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, 121552, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-6910-2021-18-2-97-108

UDC: 616.12-089: 616.94

Link: Clinical Physiology of Blood Circulaiton. 2021; 2 (18): 97-108

Quote as: Bockeria L.A., Gasymov E.G., Abdulgasanov R.A., Abdulgasanova M.R. Sepsis and septic shock in cardiovascular surgery: modern methods of diagnostics and treatment. Clinical Physiology of Circulation. 2021; 18 (2): 97–108 (in Russ.). DOI: 10.24022/1814-6910-2021-18-2-97-108

Received / Accepted:  18.01.2021 / 02.02.2021

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Abstract

Despite the improvement of surgical methods and protection of the myocardium, anesthesia, the development of perioperative myocardial infarction during cardiac surgery remains a common occurrence and is combined with a decrease in the immediate and distant survival. The pathophysiology of intraoperative myocardial infarction in cardiac surgery is based on three leading mechanisms: 1) systemic and local inflammation; 2) disorders in the blood coagulation system; 3) neuroendocrine stress. Genetic variability is present in each of these regulatory pathways. Genetic variants of different pathways may be present in the same patient, modulating the amount of myocardial injury. This review presents the published data on identified genetic variants associated with perioperative myocardial infarction in patients undergoing cardiac surgery. In the future, genetic studies can help in the preoperative prognostic assessment of the risk of myocardial infarction.

About Authors

  • Inna V. Koksheneva, Dr. Med. Sc., Senior Researcher; ORCID
  • Irakliy T. Zakaraya, Junior Researcher
  • Amina I. Maloroeva, Postgraduate

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