Clinical Physiology of Circulation

ISSN 1814-6910 (Print)
ISSN 2410-9134 (Online)

 

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Issue's catalogue ➤ КФК. 2021; 18 (4): 257-336 ➤ Вопросы генетики и риска развития тяжелых инфекционных осложнений и сепсиса в кардиохирургии. Часть 4

Issues of genetics and the risk of development of severe infectious complications and sepsis in cardiovascular surgery. Part 4

Authors: Koksheneva I.V., Zakaraya I.T., Maloroeva A.I., Iraskhanov A.Sh.

Company:
Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-6910-2021-18-4-261-272

UDC: 616.94:616.12-089.168-06

Link: Clinical Physiology of Blood Circulaiton. 2021; 4 (18): 261-272

Quote as: Koksheneva I.V., Zakaraya I.T., Maloroeva A.I., Iraskhanov A.Sh. Issues of genetics and the risk of development of severe infectious complications and sepsis in cardiovascular surgery. Part 4. Clinical Physiology of Circulation. 2021; 18 (4): 261–72 (in Russ.). DOI: 10.24022/1814-6910-2021-18-4-261-272

Keywords:  genetic variability genetic variants associated with the risk of infectious complications and sepsis genetic variability of the regulatory pathways of the inflammatory response

Received / Accepted:  07.10.2021 / 29.10.2021

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Abstract

Despite advances in the prevention and treatment of infectious complications after cardiac surgery, sepsis remains a serious problem. Immune dysfunction is the main pathophysiological process that develops in septic patients. An imbalanced immune response is responsible for a significant percentage of negative outcomes in critically ill patients. The predisposition to a severe course of the infectious process has a genetic component. Accordingly, the genetic variability that disrupts the immune response to the introduction of infectious agents may explain the ability of the immune system to respond differently to infection, the diversity of the clinical picture of the course of the infectious process, responses to treatment, and genetic predisposition to infection in each individual patient. Identification of such genetic variants can identify patients at high risk of developing sepsis and organ dysfunction during infectious processes. This review presents published data on the identified genetic variants associated with inflammatory cascades and regulatory pathways associated with severe infection and sepsis. The results of published studies on the identification of key candidate genes involved in inflammatory signaling pathways may be useful for stratification of the risk of sepsis, monitoring its development, and prognosis, while their specific functions and mechanisms during the development of the infectious process and sepsis require further study. It is likely that in the future, genotyping will be included in the routine assessment of critically ill patients and will help develop the most effective treatment modalities.

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****
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About Authors

  • Inna V. Koksheneva, Dr. Med. Sci., Senior Researcher; ORCID
  • Irakliy T. Zakaraya, Junior Researcher
  • Amina I. Maloroeva, Postgraduate
  • Atabi Sh. Iraskhanov, Resident Physician; ORCID

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