Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Genetic determinants of risk of acute kidney dam￾age during cardiac surgery. Part 5

Authors: Koksheneva I.V., Zakaraya I.T., Maloroeva A.I.

Company:
Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-6910-2022-19-1-47-56

UDC: 616.12-089:616.61-002-036.11

Link: Clinical Physiology of Blood Circulaiton. 2022; 1 (19): 47-56

Quote as: Koksheneva I.V., Zakaraya I.T., Maloroeva A.I. Genetic determinants of risk of acute kidney damage during cardiac surgery. Part 5. Clinical Physiology of Circulation. 2022; 19 (1): 47–56 (in Russ.). DOI: 10.24022/1814-6910-2022-19-1-47-56

Received / Accepted:  08.10.2021 / 01.02.2022

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Abstract

Acute renal dysfunction is a common serious complication of cardiovascular surgery. Approximately 8–15% of patients develop moderate renal failure (peak creatinine >1.0 mg/dL) and approximately 5% of patients develop renal failure requiring dialysis. The development of acute renal dysfunction has a genetic component. This review presents the published data on the identified genetic variants associated with the risk of developing acute renal failure after cardiac surgery. Genetic studies have revealed associations of the risk of renal failure with variants associated with regulatory pathways that modulate inflammatory and vasomotor responses, the development of oxidative stress to trauma, including functional alleles that affect the production of cytokines, the development of endothelial dysfunction that can cause damage to the renal tubules and microvessels. The significance of the polymorphic site of the apolipoprotein E (ApoE) gene is considered, as well as the role of other biological regulatory pathways in the development of acute renal failure. Genetic research data can potentially form the basis for the development of a tool for genetic preoperative risk stratification, which, by individual assessment of the carriage of risk alleles, will make it possible to identify cardiac surgery patients with an increased risk of acute renal failure.

About Authors

  • Inna V. Koksheneva, Dr. Med. Sci., Senior Researcher; ORCID
  • Irakliy T. Zakaraya, Junior Researcher
  • Amina I. Maloroeva, Postgraduate

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