Clinical Physiology of Circulation

ISSN 1814-6910 (Print)
ISSN 2410-9134 (Online)

 

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Issue's catalogue ➤ КФК. 2022; 19 (1): 1-96 ➤ Генетические детерминанты риска острого повреждения почек при кардиохирургических операциях. Часть 5

Genetic determinants of risk of acute kidney dam￾age during cardiac surgery. Part 5

Authors: Koksheneva I.V., Zakaraya I.T., Maloroeva A.I.

Company:
Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-6910-2022-19-1-47-56

UDC: 616.12-089:616.61-002-036.11

Link: Clinical Physiology of Blood Circulaiton. 2022; 1 (19): 47-56

Quote as: Koksheneva I.V., Zakaraya I.T., Maloroeva A.I. Genetic determinants of risk of acute kidney damage during cardiac surgery. Part 5. Clinical Physiology of Circulation. 2022; 19 (1): 47–56 (in Russ.). DOI: 10.24022/1814-6910-2022-19-1-47-56

Keywords:  genetic variability genetic variants associated with the risk of acute renal insufficiency genetic variability of regulatory pathways of the inflammatory response genetic variability of regulatory pathways of endothelial function and vascular tone genetic variability of regulatory pathways of oxidative stress genetic variability of apolipoprotein E

Received / Accepted:  08.10.2021 / 01.02.2022

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Abstract

Acute renal dysfunction is a common serious complication of cardiovascular surgery. Approximately 8–15% of patients develop moderate renal failure (peak creatinine >1.0 mg/dL) and approximately 5% of patients develop renal failure requiring dialysis. The development of acute renal dysfunction has a genetic component. This review presents the published data on the identified genetic variants associated with the risk of developing acute renal failure after cardiac surgery. Genetic studies have revealed associations of the risk of renal failure with variants associated with regulatory pathways that modulate inflammatory and vasomotor responses, the development of oxidative stress to trauma, including functional alleles that affect the production of cytokines, the development of endothelial dysfunction that can cause damage to the renal tubules and microvessels. The significance of the polymorphic site of the apolipoprotein E (ApoE) gene is considered, as well as the role of other biological regulatory pathways in the development of acute renal failure. Genetic research data can potentially form the basis for the development of a tool for genetic preoperative risk stratification, which, by individual assessment of the carriage of risk alleles, will make it possible to identify cardiac surgery patients with an increased risk of acute renal failure.

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****
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  5. Billings F.T., Ball S.K., Roberts L.J., Pretorius M. Postoperative acute kidney injury is associated with hemoglobinemia and an enhanced oxidative stress response. Free. Radic. Biol. Med. 2011; 50 (11): 1480–7. DOI: 10.1016/j.freeradbiomed.2011.02.011
  6. Gaudino M., Di Castelnuovo A., Zamparelli R., Andreotti F., Burzotta F., Iacoviello L. et al. Genetic control of postoperative systemic inflammatory reaction and pulmonary and renal complications after coronary artery surgery. J. Thorac. Cardiovasc. Surg. 2003; 126 (4): 1107–12. DOI: 10.1016/s0022-5223(03)00396-9
  7. Jaber B.L., Liangos O., Pereira B.J., Balakrishnan V.S. Polymorphism of immunomodulatory cytokine genes: implications in acute renal failure. Blood. Purif. 2004; 22 (1): 101–11. DOI: 10.1159/000074930
  8. Dalboni M.A., Quinto B.M., Grabulosa C.C., Narciso R., Monte J.C., Durão M. et al. Tumour necrosis factor-α plus interleukin-10 low producer phenotype predicts acute kidney injury and death in intensive care unit patients. Clin. Exp. Immunol. 2013; 173 (2): 242–9. DOI: 10.1111/cei.12100
  9. Susantitaphong P., Perianayagam M.C., Tighiouart H., Liangos O., Bonventre J.V., Jaber B.L. Tumor necrosis factor alpha promoter polymorphism and severity of acute kidney injury. Nephron. Clin. Pract. 2013; 123 (1–2): 67–73. DOI: 10.1159/000351684
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  18. MacKensen G.B., Swaminathan M., Ti L.K., Grocott H.P., Phillips-Bute B.G., Mathew J.P. et al. Perioperative Outcomes Research Group; Cardiothoracic Anesthesiology Research Endeavors (C.A.R.E.) Investigators of the Duke Heart Center. Preliminary report on the interaction of apolipoprotein E polymorphism with aortic atherosclerosis and acute nephropathy after CABG. Ann. Thorac. Surg. 2004; 78 (2): 520–6. DOI: 10.1016/j.athoracsur.2004.02.106
  19. Tavori H., Fan D., Giunzioni I., Zhu L., Linton M.F., Fogo A.B., Fazio S. Macrophage-derived apoESendai suppresses atherosclerosis while causing lipoprotein glomerulopathy in hyperlipidemic mice. J. Lipid. Res. 2014; 55 (10): 2073–81. DOI: 10.1194/jlr.M049874
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  21. Zhou H., Chen M., Zhu Y., Wang B., Liu X.N., Zuo Z., Tang F.Y. Polymorphisms in NADPH oxidase CYBA gene modify the risk of ESRD in patients with chronic glomerulonephritis. Ren. Fail. 2016; 38 (2): 262–7. DOI: 10.3109/0886022X.2015.1117905
  22. Perianayagam M.C., Tighiouart H., Nievergelt C.M., O'Connor D.T., Liangos O., Jaber B.L. CYBA Gene Polymorphisms and Adverse Outcomes in Acute Kidney Injury: a prospective cohort study. Nephron. Extra. 2011; 1 (1): 112–23. DOI: 10.1159/000333017
  23. Perianayagam M.C., Tighiouart H., Liangos O., Kouznetsov D., Wald R., Rao F. et al. Polymorphisms in the myeloperoxidase gene locus are associated with acute kidney injury-related outcomes. Kidney. Int. 2012; 82 (8): 909–19. DOI: 10.1038/ki.2012.235
  24. Kolyada A.Y., Tighiouart H., Perianayagam M.C., Liangos O., Madias N.E., Jaber B.L. A genetic variant of hypoxia-inducible factor-1alpha is associated with adverse outcomes in acute kidney injury. Kidney. Int. 2009; 75 (12): 1322–9. DOI: 10.1038/ki.2009.68
  25. Popov A.F., Schulz E.G., Schmitto J.D., Coskun K.O., Tzvetkov M.V., Kazmaier S. et al. Relation between renal dysfunction requiring renal replacement therapy and promoter polymorphism of the erythropoietin gene in cardiac surgery. Artif. Organs. 2010; 34 (11): 961–8. DOI: 10.1111/j.1525-1594.2010.01108.x
  26. Haase-Fielitz A., Haase M., Bellomo R., Lambert G., Matalanis G., Story D. et al. Decreased catecholamine degradation associates with shock and kidney injury after cardiac surgery. J. Am. Soc. Nephrol. 2009; 20 (6): 1393–403. DOI: 10.1681/ASN.2008080915
  27. Stafford-Smith M., Podgoreanu M., Swaminathan M., Phillips-Bute B., Mathew J.P., Hauser E.H. et al. Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. Association of genetic polymorphisms with risk of renal injury after coronary bypass graft surgery. Am. J. Kidney. Dis. 2005; 45 (3): 519–30. DOI: 10.1053/j.ajkd.2004.11.021
  28. Vilander L.M., Kaunisto M.A., Pettilä V. Genetic predisposition to acute kidney injury – a systematic review. BMC Nephrol. 2015; 16: 197. DOI: 10.1186/s12882- 015-0190-6
  29. Stafford-Smith M., Li Y.J., Mathew J.P., Li Y.W., Ji Y., Phillips-Bute B.G. et al.; Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team. Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci. Kidney. Int. 2015; 88 (4): 823–32. DOI: 10.1038/ki.2015.161

About Authors

  • Inna V. Koksheneva, Dr. Med. Sci., Senior Researcher; ORCID
  • Irakliy T. Zakaraya, Junior Researcher
  • Amina I. Maloroeva, Postgraduate

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