Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Anticoagulant treatment, blood transfusion and neurological complicationsin children at extracorporeal membrane oxygenation after cardiac surgerycorrection of congenital cardiac pathology in cardiopulmonary bypass

Authors: M.P. Chuprov, S.V. Ibragimov, L.G. Medyantseva, E.S. Kadyrberdeeva, Yu.A. Shlakin, S.S. Denisov, S.M. Smirnov

Company:
Federal Center for Cardiovascular Surgery, Ministry of Health of the Russian Federation, ul. Pokrovskaya roshcha, 4, Astrakhan, 414011, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-6910-2019-16-1-45-51

UDC: 616.12-007-053.2-089.8-78:615.273.53:615.38:616.12-089.5-06

Link: Clinical Physiology of Blood Circulaiton. 2019; 16 (1): 45-51

Quote as: Chuprov M.P., Ibragimov S.V., Medyantseva L.G., Kadyrberdeeva E.S., Shlakin Yu.A., Denisov S.S., Smirnov S.M. Anticoagulant treatment, blood transfusion and neurological complications in children at extracorporeal membrane oxygenation after cardiac surgery correction of congenital cardiac pathology in cardiopulmonary bypass. Clinical Physiology of Circulation. 2019; 16 (1): 45–51 (in Russ.). DOI: 10.24022/1814-6910-2019-16-1-45-51

Received / Accepted:  30.10.2018/24.11.2018

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Abstract

Objective. Evaluate the influence of the anticoagulation grade and the volume of blood transfusion on the development of neurological complications in children at extracorporeal membrane oxygenation (ECMO) after cardiac surgery correction of congenital heart defects (CHD) in cardiopulmonary bypass.

Material and methods. Clinical chart retrospective analysis of children underwent cardiac surgery correction of congenital heart defects in conditions of artificial circulation (AC) and who needed ECMO at post-surgical period from April 2009 to October 2017 was carried out. Patients were divided into 2 groups: group 1 – 25 children with central nervous system (CNS) damage, group 2 – 40 children without CNS damage. An assessment of anticoagulant treatment and the average volume of donor blood transfused components were carried out.

Results. In both groups no differences between the mean values of activated coagulation time (ACT) were found, however in the group with CNS damage (group 1) the volume of transfused donor blood components was significantly higher than those in the group without CNS damage (group 2).

Conclusion. Routine use of ACT is insufficient to control heparinization in patients at ECMO. Mass transfusions significantly increase the risk of developing CNS damage.

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About Authors

  • Maksim P. Chuprov, Cand. Med. Sc., Anesthesiologist-Intensivist; orcid.org/0000-0002-4908-8010
  • Stanislav V. Ibragimov, Head of Department of Anesthesiology and Resuscitation № 2, Anesthesiologist-Intensivist; orcid.org/0000-0001-6482-7929
  • Lyudmila G. Medyantseva, Cand. Med. Sc., Head of Blood Transfusion Department, Transfusiologist; orcid.org/0000-0002-8485-6636
  • El'mira S. Kadyrberdeeva, Transfusiologist; orcid.org/0000-0002-2917-4624
  • Yuriy A. Shlakin, Anesthesiologist-Intensivist; orcid.org/0000-0001-5423-8442
  • Sergey S. Denisov, Anesthesiologist-Intensivist; orcid.org/0000-0002-4028-7881
  • Sergey M. Smirnov, Cardiovascular Surgeon; orcid.org/0000-0001-8154-4736

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