Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Creation of new local coverings of hemostatic action on the basisof sodium alginate

Authors: G.G. Belozerskaya 1, D.Yu. Bychichko 1, V.A. Kabak 1, A.R. Lempert 1, O.E. Nevedrova 1, L.S. Malykhina 1, M.S. Mironov 1, Yu.S. Logvinova 1, E.M. Golubev< sup>1, T.I. Shirokova 1, V.M. Vdovin 2, A.P. Momot 3

Company:
1 National Medical Research Center for Hematology, Ministry of Health of the Russian Federation, Novyy Zykovskiy proezd, 4, Moscow, 125167, Russian Federation
2 Altai State Medical University, Ministry of Health of the Russian Federation, prospekt Lenina, 40, Barnaul, 656038, Russian Federation
3 Altay branch of the National Medical Research Center for Hematology, Ministry of Health of the Russian Federation, ul. Lyapidevskogo, 1, Barnaul, 656044, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-6910-2018-15-3-222-229

UDC: 577.1

Link: Clinical Physiology of Blood Circulaiton. 2018; 15 (3): 222-229

Quote as: Belozerskaya G.G., Bychichko D.Yu, Kabak V.A., Lempert A.R., Nevedrova O.E., Malykhina L.S., Mironov M.S., Logvinova Yu.S., Golubev E.M., Shirokova T.I., Vdovin V.M., Momot A.P. Creation of new local coverings of hemostatic action on the basis of sodium alginate. Clinical Physiology of Circulation. 2018; 15 (3): 222–9 (in Russ.). DOI: 10.24022/ 1814-6910-2018-15-3-222-229

Received / Accepted:  31.05.2018/07.07.2018

Full text:  

Abstract

Objective. Creation of new hemostatic compositions of local action in the form of a sponge based on salts of alginic acid.

Material and methods. As an experimental model, rabbits of the breed Chinchilla were used. The hemostatic activity of the samples was determined from the time of bleeding stoppage and the volume of blood loss when the hemostatic compositions were applied in the form of sponges to the standard rabbit liver wound according to the method described in the Preclinical Drug Research Guide. The dependence of the hemostatic activity of the compositions in the form of sponges based on sodium alginate on the thickness, total porosity and water absorption capacity was determined. The dependence of the hemostatic effect on the introduction into the structure of the composition in the form of a sponge based on sodium alginate, a fibrin monomer (Tekhnologiya-Standart, Barnaul).

Results. Comparative evaluation of specific pharmacological activity of various samples in the form of sponges based on sodium alginate showed that the best hemostatic effect was possessed by compositions in the form of sponges based on 3% sodium alginate and based on 1% sodium alginate with the introduction of a fibrin monomer powder in the dose of 25 mg.

Conclusion. The use of hemostatic compositions based on sodium alginate without the addition of hemostatic agents and in combination with fibrin monomer powder as local hemostatic agents can stop massive local bleeding, while the hemostatic activity of the new compositions correlates with their physico-chemical properties.

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About Authors

  • Belozerskaya Galina Gennad'evna, Dr. Med. Sc., Head of Laboratory of Pathology and Pharmacology of Hemostasis; orcid.org/0000-0001-8620-153X
  • Bychichko Dmitriy Yur'evich, Junior Researcher, Biochemist; orcid.org/0000-0003-1585-4415
  • Kabak Valeriy Alekseevich, Manager; orcid.org/0000-0002-3851-7510
  • Lempert Asaf Rudol'fovich, Postgraduate, Trainee-researcher; orcid.org/0000-0002-6576-5712
  • Nevedrova Ol'ga Evgen'evna, Cand. Biol. Sc., Senior Researcher; orcid.org/0000-0001-9752-6647
  • Malykhina Larisa Sergeevna, Cand. Biol. Sc., Senior Researcher; orcid.org/0000-0002-6231-0069
  • Mironov Maksim Sergeevich, Laboratory Assistant; orcid.org/0000-0001-5230-7424
  • Logvinova Yuliya Sergeevna, Cand. Med. Sc., Researcher, Biochemist; orcid.org/0000-0002-8392-1790
  • Golubev Evgeniy Mikhaylovich, Head of Experimental and Production Department of Deep Processing of Plasma; orcid.org/0000-0002-5405-8270
  • Shirokova Tat'yana Ivanovna, Deputy Head of Experimental and Production Department of Deep Processing of Plasma; orcid.org/0000-0002-2543-8071
  • Vdovin Vyacheslav Mikhaylovich, Cand. Med. Sc., Chief of Chair of Pathological Physiology; orcid.org/0000-0002-4606-3627
  • Momot Andrey Pavlovich, Dr. Med. Sc., Professor, Director of the Altai branch; orcid.org/0000-0002-8413-5484

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