Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, Director of Bakoulev National Medical Research Center for Cardiovascular Surgery

The effect of physical exertion on endothelial adaptation under conditions of pathophysiological changes in the cardiovascular system

Authors: T.T. Kakuchaya, T.G. Dzhitava, A.G. Filatova, A.M. Кuular, Z.K. Tokaeva, N.E. Zakaraya

Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, 121552, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.


UDC: 616.1:615.82

Link: Clinical Physiology of Blood Circulaiton. 2020; 17 (3): 165-171

Quote as: Kakuchaya T.T., Dzhitava T.G., Filatova A.G., Кuular A.M., Tokaeva Z.K., Zakaraya N.E. The effect of physical exertion on endothelial adaptation under conditions of pathophysiological changes in the cardiovascular system. Clinical Physiology of Circulation. 2020; 17 (3): 165–71 (in Russ.). DOI: 10.24022/1814-6910-2020-17-3-165-171

Received / Accepted:  09.06.2020/15.06.2020

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The endothelial layer is a key link in maintaining homeostasis, regulating the tone and structure of the vascular wall. It is endotheliocytes that play an important role in the regulation of water and macromolecular transport, adhesion and transmigration of leukocytes, the generation and metabolism of biochemical substances, changes in the functional component and proliferation of smooth muscle cells, as well as vascular remodelling under the action of vasoactive agents. Endothelial dysfunction is mainly characterized by changes in the endothelial response to irritation, including a decrease in vasodilation activity and the induction of a pro-inflammatory or prothrombotic state of the vascular wall. A number of studies have shown that regular exercise improves endothelium-dependent adaptive vascular function. These factors significantly contribute to the improvement of endothelial function and thereby reduce neurohumoral activity, which leads to an increase in peripheral perfusion and a decrease in the additional load on the heart.


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About Authors

  • Tea T. Kakuchaya, Dr. Med. Sc., Professor, Head of Department of Cardiosurgical Treatment and Rehabilitation of Adult Patients with Heart Pathology; 
  • Tamara G. Dzhitava, Cand. Med. Sc., Deputy Head of Department of Cardiosurgical Treatment and Rehabilitation of Adult Patients with Heart Pathology; 
  • Angelina G. Filatova, Cardiologist; 
  • Arzhana M. Kuular, Cand. Med. Sc., Cardiologist; 
  • Zarina K. Tokaeva, Cardiologist, Postgraduate; 
  • Nino E. Zakaraya, Junior Researcher;

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