Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


An experimental model of local aortic injury for studying the elastic-deformational properties of the aorta

Authors: Bockeria L.A., Gorodkov A.Yu., Arakelyan V.S., Zhorzholiani Sh.T., Tsygankov Yu.M., Khugaev G.A., Tibua T.R.

Company:
Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russian Federation

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DOI: https://doi.org/10.24022/1814-6910-2021-18-4-322-328

UDC: 616.132.1-001.5

Link: Clinical Physiology of Blood Circulaiton. 2021; 4 (18): 322-327

Quote as: Bockeria L.A., Gorodkov A.Yu., Arakelyan V.S., Zhorzholiani Sh.T., Tsygankov Yu.M., Khugaev G.A., Tibua T.R. An experimental model of local aortic injury for studying the elastic-deformational properties of the aorta. Clinical Physiology of Circulation. 2021; 18 (4): 322–8 (in Russ.). DOI: 10.24022/1814-6910-2021-18-4-322-328

Received / Accepted:  20.09.2021 / 03.10.2021

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Abstract

Objective. Comparison of two experimental models: elastase-induced aneurysmal expansion with local hemodynamically significant stenosis in rats, as well as the study of methods for their visualization.

Material and methods. White male rats of the Wistar breed were used as experimental animals for the development of the model. The animals were divided into three groups: in the control group, the aorta was examined unchanged, the first group (n = 10) – elastase-induced aneurysmal dilation of the abdominal aorta, the second group (n =10) – with hemodynamically significant stenosis in the infrarenal aorta.

Results. The ultrasonic duplex scanning showed that, in comparison with the control group, in the first group, local compaction and thickening of the aortic walls were visualized after 14 days, and aneurysmal expansion was confirmed after 28–30 days. Abdominal aortic aneurysm (AAA) was also visualized according to the data of intravital angiography of the entire aorta. When measuring the longitudinal-transverse dimensions of the aorta according to the data of casts and panaortography, it was revealed that in the presence of AAA, the diameter increases not only in the area of localization of expansion, but also along the aorta. The diameter of the entire aorta with local stenosis also increases when compared with the norm to the infrarenal department. Histological examination of the aortic wall throughout the aorta showed that the proximal part of the rat aorta in the presence of AAA is thinned, there is a thickening of the intima at the site of its expansion.

Conclusion. With local damage to the aorta, geometric remodeling of the entire aorta occurs, while it is more pronounced with elastase-induced aneurysmal expansion of the abdominal aorta than with local stenosis of the infrarenal aorta.

About Authors

  • Leo A. Bockeria, Dr. Med. Sci., Professor, Academician of RAS and RAMS, President; ORCID
  • Aleksandr Yu. Gorodkov, Dr. Biol. Sci., Head of Laboratory of Modeling and Study of the Pathology of Heart and Vessels with Operation Block and Vivarium; ORCID
  • Valeriy S. Arakelyan, Dr. Med. Sci., Professor, Head of Arterial Pathology Surgery Department; ORCID
  • Shota T. Zhorzholiani, Researcher; ORCID
  • Yuriy M. Tsygankov, Cand. Med. Sci., Researcher; ORCID
  • Georgiy A. Khugaev, Researcher; ORCID
  • Teona R. Tibua, Postgraduate; ORCID

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