Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Дилатационная кардиомиопатия: оценка перфузии и метаболизма миокарда по данным радионуклидных методов исследования

E-mail: Сведения доступны для зарегистрированных пользователей.

Link: Clinical Physiology of Blood Circulaiton. 2010; (): -

Full text:  

Abstract

Intensity of interstitial myocardial fibrosis in patients with dilated cardiomyopathy (DCMP) is liable to affect integrity of metabolic processes in the myocardium of the left ventricle (LV) and can be adequately evaluated with 18F-ФДГ positron emission tomography of myocardium. The main task of this investigation was to evaluate prevalence of perfusion and metabolic disorders in this category of patients. Diagnosis of myocardial viability was conducted using single-photon emission computed tomography (SPECT) with 99mTc-tekhnetril and positron emission tomography (PET) with 18F-ФДГ. 50 examined patients with DCMP were divided into groups depending on the localization of perfusion (PD) and metabolic defects (MD). It was revealed that local cardiac fibrosis pattern most probably resulted from previous myocarditis had been observed in the patients with predominant local defect of isolated ventricular walls and low metabolic heterogeneity. Fibrous changes diffusion most probably was observed in patients with high metabolic heterogeneity, perfusion-metabolic disorders of anterioposterior localization and diffuse metabolic decrease. It was revealed that perfusion-metabolic indices were characterized by more marked deviations and associated with more severe LV dysfunctions associated with disorders of anterioposterior localization.

References

1. Bulkley, B. H. Tallium 201 imaging and gated cardiac blood pool scans in patients with ischemic and idiopathic congestive cardiomyopathy / B. H. Bulkley, G. M. Hutchins, I. Bailey et al. // Circulation. - 1977. - Vol. 55, № 5. - Р. 753-760.
2. Camici, P. G. Coronary microvascular dysfunction in patients with cardiomyopathy / P. G. Camici // Circulation: heart failure - 2008. - Vol. 1. - Р. 150-152.
3. Dunn, R. F. Comparison 201Tl scanning in idiopathic dilated cardiomyopathy and sever coronary artery disease / R. F. Dunn, R. F. Uren, N. Sadick et al. // Circulation. - 1982. - Vol. 66, № 4. - Р. 804-810.
4. Hasegawa, S. Myocardial positron emission computed tomographic images obtained with fluorine-18 fluoro-2-deoxyglucose predict the response of idiopathic dilated cardiomyopathy patients to beta-blockers / S. Hasegawa, H. Kusuoka, K. Maruyama et al. // J. Amer. Coll. Cardiol. - 2004. - Vol. 43, № 2. - P. 224-233.
5. Isobe, S. Combined study with FDG PET and Tl SPECT in patients with idiopathic dilated cardiomyoopathy / S. Isobe, A. Ando, M. Nanasato et al. // Nucl. Med. Commun. - 2003. - Vol. 24. - Р. 1071-1080.
6. Juilliere, Y. Radionuclide assessment of regional difference in left ventricular wall motion and myocardial perfusion in idiopathic dilated cardiomyopathy / Y. Juilliere, P. Y. Marie, N. Danchin et al. // Eur. Heart. J. - 1993. - Vol. 14. - Р. 1163-1169.
7. Knaap, P. Perfusable tissue index as potential marker of fibrosis in patients with idiopathic dilated cardiomyopathy / P. Knaap, R. Boellaard, M. J. Gotte et al. // J. Nucl. Med. - 2004. - Vol. 45, № 8. - P. 1299-1304.
8. Li, L. X. Comparative study of 201 Tl-scintigraphic image and myocardial pathologic finding in patients with dilated cardiomyopathy / L. X. Li, R. Nohara, K. Okuda et al. // Ann. Nucl. Med. - 1996 - Vol. 10. - Р. 307-314.
9. Neglia, D. Myocardial metabolic and receptor imaging in idiopathic dilated cardiomyopathy / D. Neglia, G. Sambuceti, P. Iozzo et al. // Eur. J. Nucl. Med. - 2002. - Vol. 29. - P. 1403-1413.
10. Neri, G. Effect of biventricular pacing on metabolism and perfusion in patients affected by dilated cardiomyopathy and left bundle branch block: eval uation by positron emission tomography / G. Neri, P. Zanco, F. Zanon et al. // Europace. - 2003. - Vol. 5, № 1. - P. 111-115.
11. Nowak, B. Cardiac resynchronization therapy homogenizes myocardial glucose metabolism and perfusion in dilated cardiomyopathy and left bundle branch block / B. Nowak, A. M. Sinha, W. M. Schaefer et al. // J. Amer. Coll. Cardiol. - 2003. - Vol. 41, № 9. - P. 1523-1528.
12. ONeill, О. J. PET abnormalities in patienta with nonischemic cardiomyopathy / О. J. ONeill, P. M. McCarthy, R. C. Brunken et al. // J. Card. Fail. - 2004. - Vol. 10. - Р. 244-249.
13. Rahimtoola, S. H. Chronic ischemic left ventricular dysfunction: from pathophysiology to imaging and its integration into clinical practice / S. H. Rahimtoola, V. Dilsizian, Ch. M. Kramer et al. // JACC Cardiovascular Imaging. - 2008. - Vol. 1. - Р. 536-555.
14. Salmeron, R. J. Identification of the ischemic origin of dilated myocardiopathy using positron emission tomography / R. J. Salmeron, J. A. Lopez, M. A. Gomez et al. // Rev. Esp. Cardiol. - 1998. - Vol. 51. - Р. 67-76.
15. Schinkel, A. F. Assessment of myocardial viability in patients with heart failure / A. F. Schinkel, D. Poldermans, A. Elhendy et al. // J. Nucl. Med. - 2007. - Vol. 48. - Р. 1135-1146.
16. Taylor, M. An evaluation of myocardial fatty acid and glucose uptake using PET with [18F]fluoro-6-thia-heptadecanoic acid and [18F]FDG / M. Taylor, T. R. Wallhaus, T. R. Degrado et al. // J. Nucl. Med. - 2001. - Vol. 42. - Р. 55-62.
17. Tian, Y. Q. Radionuclide technigues for evaluating dilated cardiomyopathy and ischemic cardiomyopathy / Y. Q. Tian, X. J. Lui., R. F. Xe et al. // Chin. Med. J. - 2000. - Vol. 113, № 5. - P. 392-395.
18. Yamaguchi, H. Characteristics of myocardial 18F-fluorodeoxyglucose positron emission computed tomography in dilated cardiomiopathy and ischemic cardiomyopathy / H. Yamaguchi, S. Hasegawa, J. Yoshioka et al. // Ann. Nucl. Med. - 2000. - Vol. 14, № 1. - P. 33-38.
19. Yokoyama, I. Role of positron emission tomography using fluorine- 18-fluoro-2-deoxyglucose in predicting improvement in left ventricular function in patients with idiopathic dilated cardiomyopathy / I. Yokoyama, S. Momomura, T. Ohtake et al. // Eur. J. Nucl. Med. - 1998. - Vol. 25, № 7. - P. 736-743.

 If you found mistakes, select text and press Alt+A