Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Ремоделирование гемодинамики у пациентов с хронической анемией

E-mail: Сведения доступны для зарегистрированных пользователей.

Link: Clinical Physiology of Blood Circulaiton. 2010; (): -

Download
Full text:  

Abstract

The effect of chronic anemia on remodeling hemodynamics using echo-Doppler cardiography was established. We have examined patients with iron deficiency and B12-deficiency anemia without cardiac pathology. The average age was 46.7±8.1 years. Patients with chronic anemia without cardiac pathology were remodeling hemodynamics with the formation of hyperkinetic circulation without the Frank-Starling mechanism. With the normalization of hemoglobin level, the recover of normal systolic left ventricular function and transmitral diastolic flow is described, and the formation of cardiomyopathy is not marked. A strong inverse correlation between hemoglobin level and ejection fraction is identified.

References

1. Гончарова, Е. В. Структурно-функциональные показатели миокарда у больных хронической железодефицитной анемией / Е. В. Гончарова, А. В. Говорин, А. Г. Кузьмин и др. // Кардиология. - 2008. - Т. 48, № 5. - С. 46-50.
2. Марков, Х. М. Оксид азота и сердечно-сосудистая система / Х. М. Марков // Успехи физиол. наук. - 2001. - Т. 32, № 3. - С. 49-65.
3. Anand, I. S. Endothelium-derived relaxing factor is important in mediating the high output state in chronic severe anemia / I. S. Anand, Y. Chandrashekhar, G. S. Wander, L. S. Chawla // J. Amer. Coll. Cardiol. - 1995. - Vol. 25. - P. 1402-1407.
4. Arstall, M. A. Cytokine-mediated apoptosis in cardiac myocytes: the role of inducible nitric oxide synthase induction and peroxynitrite generation / M. A. Arstall, D. B. Sawyer, R. Fukazawa, R. A. Kelly // Circ. Res. - 1999. - Vol. 85, № 9. - P. 829-840.
5. Bers, D. M. Cardiac excitation/contraction coupling / D. M. Bers // Nature. - 2002. - Vol. 415. - P. 198-205.
6. Cash, J. M. The anemia of chronic disease: spectrum of associated diseases in series of unselected hospitalized patients / J. M. Cash, D. A. Slars // Amer. J. Med. - 1989. - Vol. 87. - P. 638.
7. Rosenthal, D. S. Hematological-oncological disorders and heart disease / D. S. Rosenthal, E. Braunwald // Heart disease: a textbook of cardiovascular medicine; ed. E. Braunwald. - Philadelphia: Saunders, 1992.
8. Sears, C. E. Cardiac neuronal nitric oxide synthase isoform regulates myocardial contraction and calcium handling / C. E. Sears, S. M. Bryant, E. A. Ashley et al. // Circ. Res. - 2003. - Vol. 92, № 5. - P. e52-e59.

 If you found mistakes, select text and press Alt+A