Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery

Short-term use of high doses of erythropoietin as a way of correctionof preoperative anemia in patient with infective endocarditis

Authors: A.A. Kupryashov, N.N. Koloskova, M.I. Rivnyak, R.M. Muratov

A.N. Bakoulev Scientific Center for Cardiovascular Surgery, Rublevskoe shosse, 135, Moscow, 121552, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

Link: Clinical Physiology of Blood Circulaiton. 2015; (): -

Quote as: Kupryashov A.A., Koloskova N.N., Rivnyak M.I., Muratov R.M.. Short-term use of high doses of erythropoietin as a way of correction of preoperative anemia in patient with infective endocarditis. Klinicheskaya Fiziologiya Krovoobrashcheniya (Clinical Physiology of Circulation, Russian journal). 2015; 2: 51-53 (in Russ.)

Full text:  


We report a preoperative preparation of patients with prosthetic infective endocarditis and anemia by short course erythropoietin. It’s total dose was 79,000 IU. Against the background of its application note stabilization of hematological parameters and increase exercise tolerance. The forth heart procedure and postoperative period was not complication and were accompanied by a minimum volume transfusions of red blood cells.


  1. Ranucci M., Di Dedda U., Castelvecchio S., Menicanti L., Frigiola A., Pelissero G. Surgical and Clinical Outcome Research (SCORE) Group. Impact of preoperative anemia on outcome in adult cardiac surgery: a propensity-matched analysis. Ann. Thorac. Surg. 2012; 94: 1134–41.
  2. Arora N.P., Ghali J.K. Iron deficiency anemia in heart failure. Heart Fail. Rev. 2013; 18: 485–501.
  3. Guo L., Wang A.H., Sun Y.L., Lv L., Xu C.E. Serum erythropoietin level predicts the prognosis of chronic heart failure with or without anemia. Exp. Ther. Med. 2013; 6: 1327–31.
  4. Martinez-Ruiz A., Tornel-Osorio P.L., Sanchez-Mas J., Perez-Fornieles J., Vilchez J.A., Martinez-Hernandez P., Pascual-Figal D.A. Soluble TNFα receptor type I and hepcidin as determinants of development of anemia in the longterm follow-up of heart failure patients. Clin. Biochem. 2012; 45: 1455–8.
  5. Ruifrok W.P., Qian C., Sillje H.H., van Goor H., van Veldhuisen D.J., van Gilst W.H., de Boer R.A. Heart failure-associated anemia: bone marrow dysfunction and response to erythropoietin. J. Mol. Med. (Berl). 2011; 89: 377–87.
  6. Mahmud H., Ruifrok W.P., Westenbrink B.D., Cannon M.V., Vreeswijk-Baudoin I., van Gilst W.H. et al. Suicidal erythrocyte death, eryptosis, as a novel mechanism in heart failureassociated anaemia. Cardiovasc. Res. 2013; 98: 37–46.
  7. Mozos I. Mechanisms linking red blood cell disorders and cardiovascular diseases. Biomed. Res. Int. 2015; 2015: 682054.

 If you found mistakes, select text and press Alt+A