Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


The role of humoral and cellular immunoreactivity in progressionof coronary atherosclerosis

Authors: D.S. Shcheglov 1, L.V. Shcheglova 1, M.V. Avdeeva 1, 2, O.V. Ivleva 3

Company:
1St. Petersburg State Pediatric Medical University, Ministry of Health of the Russian Federation, ul. Litovskaya, 2, St. Petersburg, 194100, Russian Federation 2North-Western State Medical University named after I.I. Mechnikov, Ministry of Health of the Russian Federation, Piskarevskiy prospekt, 47, St. Petersburg, 195067, Russian Federation 3 Bakoulev National Medical Research Center for Cardiovascular Surgery, Ministry of Health of the Russian Federation, Rublevskoe shosse, 135, Moscow, 121552, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-6910-2018-15-1-32-39

UDC: 616.132.2-004.6:579.61:612.017.1

Link: Clinical Physiology of Blood Circulaiton. 2018; 15 (1): 32-39

Quote as: Shcheglov D.S., Shcheglova L.V., Avdeeva M.V., Ivleva O.V. The role of humoral and cellular immunoreactivity in progression of coronary atherosclerosis. Klinicheskaya Fiziologiya Krovoobrashcheniya (Clinical Physiology of Circulation, Russian journal). 2018; 15 (1): 32–9 (in Russ.). DOI: 10.24022/1814-6910-2018-15-1-32-39

Received / Accepted:  07.12.2017/08.12.2017

Download
Full text:  

Abstract

Objective. To examine the relationship of cellular and humoral immunoreactivity with the severity of the atherosclerotic coronary lesions in patients with stable angina.

Material and methods. We examined 67 patients with stable angina (mean age 60,1±10,1 years), which underwent a coronary angiography and immunological studies.

Results. We revealed a direct correlation between the level of circulating immune complexes and presence of hemodynamically significant coronary stenosis (R=0,31; p<0,05), as well as a number of them (r=0,27; p<0,05) and length stenosis (R=0,31; p<0,05). It was also a correlation between the level of circulating immune complexes and the degree of stenosis in coronary arteries (r=0,35–0,25; p<0,05). Levels of the myocardial antigen associated with number of coronary occlusions (r=0,49; p<0,05), number of hemodynamically significant stenosis (r=0,58; p<0,05) and degree of coronary stenosis (r=0,56–0,45; p<0,05). The number of coronary occlusions associated with the leukocyte migration-inhibitory index stimulated with phytohemagglutinin (r=0,40; p<0,05).

Conclusion. Cellular and humoral immunoreactivity plays an important pathogenic role in the progression of atherosclerotic lesions of the coronary arteries, which should be considered in the treatment of patients with stable angina.

References

  1. Левина Л.И., Щеглов Д.С., Щеглова Л.В., Карповская Е.Б. Аутоиммунные реакции гуморального и клеточного типа у больных со стабильной стенокардией и их зависимость от степени поражения коронарного русла. Вестник Санкт-Петербургского университета. Медицина. 2014; 4: 36–43. [Levina L.I., Shcheglov D.S., Shcheglova L.V., Karpovskaya E.B. Autoimmune reactions of humoral and cellular types in patients with stable angina pectoris depending on severity of coronary involvement. Vestnik Sankt-Peterburgskogo Universiteta. Meditsina (Vestnik of Saint Petersburg University. Medicine). 2014; 4: 36–43 (in Russ.).]

  2. Ketelhuth D.F., Hansson G.K. Adaptive response of T and B cells in atherosclerosis. Circ. Res. 2016; 118 (4): 668–78.

  3. Chistiakov D.A., Orekhov A.N., Bobryshev Y.V. Immune-inflammatory responses in atherosclerosis: role of an adaptive immunity mainly driven by T and B cells. Immunobiology. 2016. DOI: 10.1016/ j.imbio.2016.05.010

  4. Frostegard J. Immunity, atherosclerosis and cardiovascular disease. BMC Med. 2013; 11: 117–25.

  5. Авдеева М.В., Самойлова И.Г., Щеглов Д.С. Патогенетические аспекты взаимосвязи инфекционных заболеваний ротовой полости с развитием и прогрессированием атеросклероза и возможности их комплексной профилактики. Журнал инфектологии. 2012; 4 (3): 30–4. [Avdeeva M.V., Samoylova I.G., Shcheglov D.S. Pathogenetic aspects of infectious agents influence on the development and progression of cardiovascular disease. Zhurnal Infektologii (Journal of Infectology, Russian journal). 2012; 4 (3): 30–4 (in Russ.).]

  6. Щеглов Д.С., Авдеева М.В., Щеглова Л.В., Дуданов И.П. Современное представление о триггерах иммуновоспалительных реакций при атеросклерозе (по данным метаанализа). Медицинский академический журнал. 2016; 16 (1): 17–26. [Shcheglov D.S., Avdeeva M.V., Shcheglova L.V., Dudanov I.P. Current concepts about triggers of inflammatory reactions in atherosclerosis (a meta-analysis of published data). Meditsinskiy Akademicheskiy Zhurnal (Medical Academic Journal, Russian journal). 2016; 16 (1): 17–26 (in Russ.).]

  7. Руф Р.Р. Роль воспаления в развитии атеросклероза и сердечно-сосудистых событий. Сибирское медицинское обозрение. 2015; 96 (6): 23–9. [Ruf R.R. The role of inflammation in the development of atherosclerosis and cardiovascular events. Sibirskoe Meditsinskoe Obozrenie (Siberian Medical Review, Russian journal). 2015; 96 (6): 23–9 (in Russ.).]

  8. Nus M., Mallat Z. Immune-mediated mechanisms of atherosclerosis and implications for the clinic. Expert. Rev. Clin. Immunol. 2016; 12 (11): 1217–37.

  9. Лефковиц И., Пернис Б. Методы исследования в иммунологии. М.: Мир; 1981. [Lefkowitz J., Pernis B. Research methods in immunology. Moscow: Mir; 1981 (in Russ.).]

  10. Мазуров В.И., Столов С.В., Беляева И.Б., Трофимов Е.А. Участие иммуновоспалительных механизмов в патогенезе коронарного атеросклероза. Вестник СЗГМУ им. И.И. Мечникова. 2015; 7 (4): 13–23. [Mazurov V.I., Stolov S.V., Belyaeva I.B., Trofimov E.A. The participation of immune and inflammatory mechanisms in the pathogenesis of coronary atherosclerosis. Vestnik SZGMU im. I.I. Mechnikova (Herald of North-Western State Medical University named after I.I. Mechnikov, Russian journal). 2015; 7 (4): 13–23 (in Russ.).]

  11. Roux-Lombard P., Pagano S., Montecucco F., Satta N., Vuilleumier N. Auto-antibodies as emergent prognostic markers and possible mediators of ischemic cardiovascular diseases. Clin. Rev. Allergy Immunol. 2013; 44 (1): 84–97.

  12. Zhang J., Wang D., He S. Roles of antibody against oxygenized low density lipoprotein in atherosclerosis: recent advances. Int. J. Clin. Exp. Med. 2015; 8: 11922–9.

  13. Nilsson J., Wigren M., Shah P.K. Vaccines against atherosclerosis. Expert Rev. Vaccines. 2013; 3: 311–21.

About Authors

  • Shcheglov Dmitriy Sergeevich, Researcher
  • Shcheglova Larisa Vasil'evna, Dr. Med. Sc., Professor, Head of Department Avdeeva Marina Vladimirovna, Dr. Med. Sc., Professor of Department; orcid.org/0000-0002-4334-5434
  • Ivleva Ol'ga Viktorovna, Cand. Med. Sc., Researcher; orcid.org/0000-0002-0447-4858

 If you found mistakes, select text and press Alt+A