Clinical Physiology of Circulation

ISSN 1814-6910 (Print)
ISSN 2410-9134 (Online)

 

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Issue's catalogue ➤ КФК. 2023; 20 (1): 1-88 ➤ Восстановление гемодинамики в раннем послеоперационном периоде после геометричекой реконструкции левого желудочка

Hemodynamic recovery in the early postoperative period after geometric reconstruction of the left ventricle

Authors: Lobacheva G.V., Alshibaya M.D., Mamalyga M.L., Musin D.E., Cheishvili Z.M., Krymov K.V., Maksimova A.G.

Company:
Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-6910-2023-20-1-16-23

UDC: 616.124.2:612.13]-089.168.1

Link: Clinical Physiology of Blood Circulaiton. 2023; 1 (20): 16-23

Quote as: Lobacheva G.V., Alshibaya M.D., Mamalyga M.L., Musin D.E., Cheishvili Z.M., Krymov K.V., Maksimova A.G. Hemodynamic recovery in the early postoperative period after geometric reconstruction of the left ventricle. Clinical Physiology of Circulation. 2023; 20 (1): 16–23 (in Russ.). DOI: 10.24022/1814-6910-2023-20-1-16-23

Keywords:  geometrical reconstruction of the left ventricle central hemodynamics targeted therapy

Received / Accepted:  15.02.2023 / 17.03.2023

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Abstract

Objective. To develop an optimal protocol of targeted therapy to restore hemodynamics in patients in the early postoperative period after geometric reconstruction of the left ventricle (GRLV) and study the effectiveness of their use.

Material and methods. 45 patients underwent GRLV were studied. The patients were divided into 2 groups: group I – patients who in the early postoperative period chose the strategy of oxygen delivery control, group II – the strategy of central hemodynamic parameters control. All patients before and after GRLV surgery had central hemodynamic and oxygen transport calculations, 6-minute walk test, extracellular fluid dynamics were assessed by integrated rheovasography using Diamant-R complex. Statistical data analysis was performed using SPSS computer program.

Results. Analysis of the study results showed that the first postoperative day was characterized by a decrease in oxygen delivery in patients of groups I and II by 39.7% and 46.4%, respectively. At the same time cardiac output in the studied groups remained at preoperative level, and stroke volume in groups I and II was decreased by 27% and 30.3%, respectively. Integral rheography revealed an increase in extracellular fluid in groups I and II by 25.6% and 28%, respectively. The third postoperative day was characterized by restoration of oxygen delivery in group I, whereas in group II it remained reduced by 36% from the preoperative level. Similar dynamics persisted in the oxygen consumption index. Cardiac output, stroke volume, left ventricular work index remained at the preoperative level. Pulmonary vascular resistance index (PVRI) in group I decreased 1.64-fold, whereas in group II it remained at the preoperative level. The volume of extracellular fluid in group I exceeded the preoperative level by 24.7%, and in group II by 26.5%. The sixth postoperative day is characterized by the recovery of oxygen consumption to the preoperative level. At the same time, oxygen delivery in group II remains reduced by 25.6%, in contrast to group I, where the preoperative level of delivery is maintained. In group II, there was a 31.4% decrease in PVRI and pulse peripheral vascular resistance index (PPVRI) to the preoperative level. On the ninth postoperative day, oxygen delivery in group II reaches the preoperative level. Thus, oxygen delivery in group I is faster and reaches the preoperative level on day 3, whereas in group II it reaches the preoperative level only on day 9. There was also a more rapid reduction of left ventricular afterload in group I. This is evidenced by the recovery of PPVRI in group I on day 3, whereas in group II it occurs only on day 6. Left ventricular stroke work index in group I was 31.5% higher than in group II. By day 9, hydrobalance in group II is restored to the preoperative level.

Conclusion. The studies have shown that early postoperative recovery in GRLV cannot be limited to the assessment of hemodynamic parameters only; the effective recovery of patients requires control and targeted correction of oxygen balance. Its control provides an opportunity to decrease postload more quickly, to increase LV index and to improve microcirculation in early postoperative period. Moreover, in compression compensated chronic heart failure the preoperative values of systemic hemodynamics and oxygen delivery can serve as an individual target level, which should be achieved in early postoperative period. The strategy aimed at restoration of oxygen delivery contributes to faster activation of the patient.

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About Authors

  • Galina V. Lobacheva, Dr. Med. Sci., Professor, Head of Department of Intensive Care Unit; ORCID
  • Mikhail D. Alshibaya, Dr. Med. Sci., Professor, Head of Department of Surgical Treatment of Coronary Heart Disease; ORCID
  • Maksim L. Mamalyga, Dr. Med. Sci., Leading Researcher; ORCID
  • Dzhanybek E. Musin, Cand. Med. Sci., Senior Researcher; ORCID
  • Zurab M. Cheishvili, Cand. Med. Sci., Senior Researcher; ORCID
  • Konstantin V. Krymov, Researcher; ORCID
  • Anna G. Maksimova, Anesthesiologist-Intensivist; ORCID

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